Antidiabetic potential of Butea monosperma in rats

Somani, Rahul; Kasture, Sanjay; Singhai, A. K.

doi:10.1016/j.fitote.2005.11.003

Cited by 79 publications

(36 citation statements)

References 3 publications

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“…27 Global expenditure on the treatment of diabetes and its accompanying complications such as hyperlipidemia and hypertension, 8 could reach US $ trillion annually. 60 It was reported that free radicals generated by hyperglyce-…”

Section: Reomentioning

confidence: 99%

Designing monographs for Rosmarinus officinalis L. and Lavandula angustifolia L.: Two Lebanese species with significant medicinal potentials

Koleilat¹,

Raafat²,

El-Lakany³

et al. 2017

Phcog J

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Introduction:The world health organization recommends validating medicinal plants to ensure safety and efficacy. Lavandula is valued for the production of essential oil used in aromatherapy. Rosmarinus is known for its folk use as anti-oxidant and antidiabetic. This study aims to design monographs for Rosmarinus officinalis (Linn.) and Lavandula angustifolia (Linn.) cultivated, in conditions similar to their natural habitat, at Beirut Arab University botanical garden. Also screening the antioxidant activity of both plants, and assessing the antidiabetic effect of R. officinalis (Linn.). Methods: macroscopic and microscopic examination, hydrodistillation to obtain essential oils (EOs), thin layer chromatography, Gas chromatography-Mass spectrometry, and physiochemical properties of the EOs were determined. The antioxidant effect of the EOs is determined by DPPH assay. The antidiabetic effect of Rosemary EO is investigated using alloxan-induced diabetic mice. Results: the qualities of studied species are in agreement with the standards described in WHO monographs and in the British pharmacopeia. Composition of the EO produced from either Rosemary (REO) or Lavender (LEO) collected at different months showed differences. The EO of both showed significant antioxidant effects in DPPH assay (p<0.05). In vivo investigation of the antidiabetic effect of REO showed a significant antidiabetic effect in diabetic mouse model (p<0.05). Conclusion: both plant species and their EOs fulfilled most of standards specified by the British Pharmacopeia 2013. Rosemary collected in April (Spring) showed the best antioxidant activity. Lavender collected in September (Early Fall) showed the best antioxidant activity. REO revealed significant lowering in blood glucose level at the dose of 110 mg/kg.

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Section: Reomentioning

confidence: 99%

Designing monographs for Rosmarinus officinalis L. and Lavandula angustifolia L.: Two Lebanese species with significant medicinal potentials

Koleilat¹,

Raafat²,

El-Lakany³

et al. 2017

Phcog J

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“…The folklore uses flowers and leaves of Butea monosperma are anticonvulsant, antioxidant, antistress, and memory and behaviour stimulant, antigout, diuretic, anti-inflammatory, antiulcer, astringent and antihepatotoxic 6,7 . The plant is known to have hepatoprotective 8 , anti-inflammatory 9 , anti-diabetic 10 , anti-stress, anti-diarrheal, aphrodisiac, diuretic, febrifuge, anti-arthritic and anti-estrogenic 11 activities. Butea monosperma flowers contain butin and butrin, isobutrin, palasitrin, coreipsin and isocoreipsin, chalcones, and aurones 12 .…”

Section: Introductionmentioning

confidence: 99%

Mechanistic Evaluation of Butea Monosperma Using in Vitro and in Vivo Murine Models of Bronchial Asthma

Shirole¹,

Sutariya²,

Saraf³

2013

Int. J. Res. Ayurveda Pharm.

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The present investigation aimed to elucidate the probable mechanism of antiasthmatic action of Butea monosperma. Bioactive fractionations of methanolic extract of B. monosperma (MBM) were carried out to get, ethyl acetate fraction (EBM) and butanolic fraction (BBM) of Butea monosperma. All fractions were evaluated mechanistically for its antiasthmatic actions in vitro using lipoxygenase assay. The lipoxygenase inhibitory effect of the extract followed the order BBM > MBM > EBM. Based on in vitro lipoxygenase assay BBM was selected for in vitro compound 48/80 induced mast cell degranulation assay and in vivo lipopolysaccharide induced inflammation in rats. BBM 50, 100 and 200μg/ml inhibited compound 48/80 induced mast cell degranulation. BBM exhibited dose dependent (50, 100 and 200mg/kg i.p.) inhibition of lipopolysaccharide-induced increased in total cell count, differential leukocyte count, nitrate-nitrite, total protein and albumin levels in bronchoalveolar fluid (BALF) and myeloperoxidase (MPO) levels in lungs homogenate.

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“…B. monosperma flowers are reported to contain butrin, isobutrin, butein, butin, flavonoids, glycosides and steroids. It has been dubbed a wonder drug and is reported to possess chemopreventive and anticancer (Choedon et al 2010), anti-hepatotoxic (Sharma and Shukla 2011), and antidiabetic (Somani et al 2006) properties. The bark exudes a red juice that dries to form Butea gum.…”

Section: Introductionmentioning

confidence: 99%

Free radical scavenging activity, phenolic contents and phytochemical evaluation of different extracts of stem bark ofButea monosperma(Lam.) Kuntze

Salar

Seasotiya

2011

Frontiers in Life Science

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The antioxidant activity, phenolic contents and phytochemical profile of acetone, methanol, water and ethyl acetate extracts of the stem bark of B. monosperma were investigated. Extracts showed highest antioxidant activity at 100 μg ml −1 with application of different assays: 2 -2 diphenyl-2 picrylhydrazyl (DPPH) scavenging (83.5% and 78.1%), reducing power (1.85 and 1.78), deoxyribose degradation site-specific (65.5% and 61.5%) and non-site-specific (67.1% and 66.5%) and chelating power (63.4% and 58.9%) in decreasing and increasing polarity of acetone extracts, respectively. However, nitroblue tetrazolium (NBT) showed scavenging of O 2 • radicals by 56.4% and 53.1% in decreasing and increasing polarity methanol extracts, respectively. Similarly, electron paramagnetic resonance (EPR)/spin-trapping exhibited highest radical scavenging activity with acetone extracts (12.6 mg g −1 Trolox). The results pointed to the significant antioxidant activities in acetone and methanol extracts. In most cases, the extracts obtained through decreasing polarity showed higher antioxidant activity. The phenolic content exhibited a strong association (r 2 > 0.9) with antioxidant activity. These results suggest that bark of B. monosperma can be a potential source of natural antioxidants.

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Antidiabetic potential of Butea monosperma in rats

Cited by 79 publications

References 3 publications

Designing monographs for Rosmarinus officinalis L. and Lavandula angustifolia L.: Two Lebanese species with significant medicinal potentials

Designing monographs for Rosmarinus officinalis L. and Lavandula angustifolia L.: Two Lebanese species with significant medicinal potentials

Mechanistic Evaluation of Butea Monosperma Using in Vitro and in Vivo Murine Models of Bronchial Asthma

Free radical scavenging activity, phenolic contents and phytochemical evaluation of different extracts of stem bark ofButea monosperma(Lam.) Kuntze

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