Antidiabetic, Lipid Normalizing, and Nephroprotective Actions of the Strawberry: A Potent Supplementary Fruit

Mandave, Pallavi; Khadke, Suresh; Karandikar, Manjiri; Pandit, Vijaya; Ranjekar, P. K.; Kuvalekar, Aniket; Mantri, Nitin

doi:10.3390/ijms18010124

Cited by 23 publications

(22 citation statements)

References 76 publications

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“…Oral administration of strawberry leaf extract decreases the serum levels of TNF-α in a rat model of diabetic nephropathy [ 56 ]. Oral administration of different strawberry extracts down-regulated the expression of TNF-α in nicotinamide–streptozotocin-induced diabetes in rats [ 57 ]. Furthermore, we previously showed that the methanolic extract of strawberry effectively attenuated cadmium-induced inflammation in liver [ 21 ], kidney [ 5 ], and testis [ 22 ] tissues.…”

Section: Discussionmentioning

confidence: 99%

Protective effects ofFragaria ananassamethanolic extract in a rat model of cadmium chloride-induced neurotoxicity

et al. 2018

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Cadmium (Cd) is a common environmental toxicant that has harmful effects on plants, animals, and humans. The present study evaluated the protective effects of Fragaria ananassa methanolic extract (SME) on cadmium chloride (CdCl2)-induced neuronal toxicity in rats. Male albino rats were intraperitoneally (i.p) injected with CdCl2 (6.5 mg/kg) for 5 days with or without the SME (250 mg/kg). We measured the levels of Cd, lipid peroxidation (LPO), nitric oxide, glutathione (GSH), and oxidative enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase, and glutathione reductase (GR) in the whole brain homogenate. Compared with the control group, the Cd-intoxicated group showed a marked increase in the brain levels of Cd, LPO, and nitric oxide and a decrease in the levels of GSH and all tested antioxidant enzymes. Compared with Cd-intoxicated rats, the rats pretreated with SME showed restoration of oxidative balance in the brain tissue. While the expression of brain SOD2, CAT, glutathione peroxidase 1, and GR was down-regulated in the Cd-treated group, the expression of these enzymes was up-regulated in rats pretreated with SME. In addition, administration of SME before CdCl2 increased the Bcl-2 expression, but significantly decreased the expression of Bax. Immunohistochemical analysis showed that compared with Cd-intoxicated rats, rats pretreated with SME showed a decrease in the protein expression of tumor necrosis factor α (TNF-α). Our findings indicate that SME protects the brain tissue from Cd-induced neuronal toxicity by improving the antioxidant system and increasing antiapoptotic and anti-inflammatory activities.

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Section: Discussionmentioning

confidence: 99%

Protective effects ofFragaria ananassamethanolic extract in a rat model of cadmium chloride-induced neurotoxicity

et al. 2018

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“…integrin-linked kinase, EMT, MMP-9/TIMP-1 ratio [127] ( 10 Journal of Diabetes Research 12 Journal of Diabetes Research ↓: decreased/prevented the increase (of activity (for enzymes)/level (for biochemical parameters))/inhibited/inactivated/blocked/suppressed/downregulated (about pathways, enzymes, receptors, cytokines, etc. ); ↑: increased/prevented the decrease (of activity (for enzymes)/level (for biochemical parameters))/stimulated/activated/upregulated; →: [172], Chlorella pyrenoidosa [173], Cladophora glomerata [34], Coccinia indica [111], coconut water [61], Cordyceps militaris [114], Cornus officinalis [47], curcumin [79], dihydroquercetin [48], Dioscorea bulbifera [96], diosgenin [62], ellagic acid [37], emodin § [94], Flammulina velutipes [53], Fragaria × ananassa [89], Huangqi decoction [36], Hypericum perforatum [31], Paederia foetida [78], Paeonia emodi [63], palm oil and rice bran oil [50], Panax notoginseng [35], Panax quinquefolium [82], Panax quinquefolium [83], Physalis angulata [64], Pleurotus eryngii polysaccharides [57], Prunella vulgaris [84], Punica granatum [32], quercetin [49], Ramulus mori [77], Rheum ribes [175], secoisolariciresinol diglucoside [88], Spirogyra neglecta [176], Tangke decoction [116], Terminalia chebula [33] Insulin resistance…”

Section: In Vitro Studies-potentially Nephroprotectivementioning

confidence: 99%

Mechanisms of Herbal Nephroprotection in diabetes mellitus

Dragoș

Manea

Timofte

et al. 2020

Journal of Diabetes Research

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Diabetic nephropathy (DN) is a leading cause of kidney morbidity. Despite the multilayered complexity of the mechanisms involved in the pathogenesis of DN, the conventional treatment is limited to just a few drug classes fraught with the risk of adverse events, including the progression of renal dysfunction. Phytoceuticals offer a promising alternative as they act on the many-sidedness of DN pathophysiology, multitargeting its intricacies. This paper offers a review of the mechanisms underlying the protective action of these phytoagents, including boosting the antioxidant capabilities, suppression of inflammation, averting the proliferative and sclerosing/fibrosing events. The pathogenesis of DN is viewed as a continuum going from the original offense, high glucose, through the noxious products it generates (advanced glycation end-products, products of oxidative and nitrosative stress) and the signaling chains consequently brought into action, to the harmful mediators of inflammation, sclerosis, and proliferation that eventually lead to DN, despite the countervailing attempts of the protective mechanisms. Special attention was given to the various pathways involved, pointing out the ability of the phytoagents to hinder the deleterious ones (especially those leading to, driven by, or associated with TGF-β activation, SREBP, Smad, MAPK, PKC, NF-κB, NLRP3 inflammasome, and caspase), to promote the protective ones (PPAR-α, PPAR-γ, EP4/Gs/AC/cAMP, Nrf2, AMPK, and SIRT1), and to favorably modulate those with potentially dual effect (PI3K/Akt). Many phytomedicines have emerged as potentially useful out of in vitro and in vivo studies, but the scarcity of human trials seriously undermines their usage in the current clinical practice—an issue that stringently needs to be addressed.

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“…Enzim ppar-γ bekerja memproduksi rna messenger yang akan membentuk glut4. Pembentukan glut 4 yang lebih banyak akan menyebabkan glukosa yang masuk dalam sel semakin banyak [27], [28]. Asam klorogenat juga mampu mencegah dan mengobati penyakit kronis metabolik, seperti sindrom metabolik dan diabetes tipe 2 [29].…”

Section: Pengamatan Manifestasi Klinikunclassified

AKTIVITAS ANTIDIABETES EKSTRAK ETANOLIK DAUN KOPI ROBUSTA (Coffea canephora) PADA TIKUS DIABETES TIPE 2 YANG DIBERI DIET LEMAK TINGGI DAN SUKROSA

Shiyan

Herlina

Arsela

et al. 2017

JFSP

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Daun kopi robusta (Coffea canephora) memiliki potensi sebagai agen antioksidan dan antidiabetes karena kandungan senyawa fenolik yang melimpah. Penelitian ini bertujuan untuk mengetahui potensi ekstrak etanolik daun kopi robusta (EEDK) terhadap penurunan kadar glukosa darah. Hewan uji dibagi menjadi kelompok normal, kontrol negatif (NaCMC 0,5%), kontrol positif (metformin 34,6 mg/200 gBB), dan tiga perlakuan (EEDK dosis 59, 118, dan 236 mg/kgBB). Pemodelan tikus diabetes dengan pemberian sukrosa dan diet lemak tinggi selama 85 hari. Ekstrak diberikan pada hari ke-86 sampai 100, kadar glukosa darah diukur hari 91; 96 dan 101. Penurunan kadar glukosa darah kelompok kontrol positif sebesar 69,26%. Kelompok perlakuan ekstrak berturut-turut 47,05%; 56,93% dan 72,48%. Ekstrak daun kopi robusta memiliki aktivitas sebagai antidiabetes dan tidak terdapat perbedaan dibandingkan metformin (p>0,05). Rata-rata nilai AUC96-101 yang paling rendah dan mempunyai persentase penurunan kadar glukosa darah yang paling besar ditunjukan oleh EEDK dosis 236 mg/kgBB. Nilai ED50 EEDK yaitu 126,90 mg/kg BB. Daun kopi robusta memiliki potensi sebagai agen antidiabetes.

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Antidiabetic, Lipid Normalizing, and Nephroprotective Actions of the Strawberry: A Potent Supplementary Fruit

Cited by 23 publications

References 76 publications

Protective effects ofFragaria ananassamethanolic extract in a rat model of cadmium chloride-induced neurotoxicity

Protective effects ofFragaria ananassamethanolic extract in a rat model of cadmium chloride-induced neurotoxicity

Mechanisms of Herbal Nephroprotection in diabetes mellitus

AKTIVITAS ANTIDIABETES EKSTRAK ETANOLIK DAUN KOPI ROBUSTA (Coffea canephora) PADA TIKUS DIABETES TIPE 2 YANG DIBERI DIET LEMAK TINGGI DAN SUKROSA

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