Antidiabetic effects of dendropanoxide from leaves of Dendropanax morbifera Leveille in normal and streptozotocin-induced diabetic rats

Moon, Hyung‐In

doi:10.1177/0960327110382131

Cited by 83 publications

(67 citation statements)

References 14 publications

(13 reference statements)

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“…10% of its climatically suitable habitats would remain in 2050 and 2070. D. morbifera has been an economically important species that provides sources for traditional medicines for multiple diseases in the ROK [71]. Therefore, the habitat loss of D. morbifera will cause significant economic loss in ROK.…”

Section: Discussionmentioning

confidence: 99%

Effects of Climate Change on the Climatic Niches of Warm-Adapted Evergreen Plants: Expansion or Contraction?

Koo

Park

Seo

2017

Forests

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Abstract:Climate change has modified the structure and functions of ecosystems, affecting human well-being. Evergreen plants in the warm-temperate ecosystems will lose climatically suitable habitats under climate change but have not drawn much scholarly interest. Therefore, the present research aimed to predict the future climatic niches of eight coastal warm-adapted evergreen trees under climate change to provide information for an effective management practice. For this purpose, we used the ensemble species distribution models (SDMs) weighted by the TSS value in modelling the climatic niches of those evergreen trees and then ensembled their future distributions predicted under 20 future climate scenarios. Except for Neolitsea sericea (True Skill Statistic (TSS) = 0.79), all projections for the current climatic niches of evergreens showed excellent predictive powers (TSS > 0.85). The results showed that the climatic niches of the four evergreens-Castanopsis cuspidata, Pittosporum tobira, Raphiolepis indica var. umbellate, and Eurya emarginata-would expand to the northern part of the Korean Peninsula (KP) under climate change, but the ones of the remaining four-Kadsura japonica, Neolitsea sericea, Ilex integra, and Dendropanax morbiferus-would shrink. While the climatic niches of Pittosporum tobira showed the rapidest and greatest expansion under climate change, Dendropanax morbiferus was predicted to experience the greatest loss of habitat. On the other hand, regardless of whether the future distributions of climatically suitable habitats would expand or contract, the highly suitable habitats of all species were predicted to decline under climate change. This may indicate that further climate change will degrade habitat suitability for all species within the distribution boundary and restrict continuous habitat expansions of expanding species or accelerate habitat loss of shrinking species. In addition, the future distributions of most coastal evergreens were found to be confined to coastal areas; therefore, sea-level rise would accelerate their habitat loss under climate change. The present study provides primary and practical knowledge for understanding climate-related coastal vegetation changes for future conservation planning, particularly on the Korean Peninsula.

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Section: Discussionmentioning

confidence: 99%

Effects of Climate Change on the Climatic Niches of Warm-Adapted Evergreen Plants: Expansion or Contraction?

Koo

Park

Seo

2017

Forests

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“…9,10 In this regard, D. morbifera leaves and stems have been used in oriental medicine in Korea and People's Republic of China and have been reported to have beneficial effects in numerous diseases. 7,17,18 In this study, D. morbifera leaves were used for the first time for the green synthesis of D-AgNPs and D-AuNPs, which were further studied for their in vitro anticancer efficacies.…”

Section: Resultsmentioning

confidence: 99%

Rapid green synthesis of silver and gold nanoparticles using<em> Dendropanax morbifera</em> leaf extract and their anticancer activities

Kim¹,

Wang²,

Mathiyalagan³

et al. 2016

IJN

110

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Dendropanax morbifera Léveille is an oriental medicinal plant that is traditionally used in folk medicine and grows in a specific region of South Korea. We aimed to enhance the utilization of D. morbifera medicinal plants for synthesis of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs). D. morbifera leaf extract acted as both a reducing and a stabilizing agent that rapidly synthesized Dendropanax AgNPs (D-AgNPs) and Dendropanax AuNPs (D-AuNPs). The D-AgNPs and D-AuNPs were characterized by ultraviolet-visible spectroscopy, energy dispersive X-ray analysis, elemental mapping, field emission transmission electron microscopy, X-ray diffraction, and dynamic light scattering. The characterizations revealed that the D-AgNPs and D-AuNPs were in polygon and hexagon shapes with average sizes of 100–150 nm and 10–20 nm, respectively. The important outcomes were the synthesis of AgNPs and AuNPs within 1 hour and 3 minutes, respectively, avoiding the subsequent processing for removal of any toxic components or for stabilizing the nanoparticles. Additionally, D-AgNPs and D-AuNPs were examined for cytotoxicity in a human keratinocyte cell line and in A549 human lung cancer cell line. The results indicated that D-AgNPs exhibited less cytotoxicity in the human keratinocyte cell line at 100 µg/mL after 48 hours. On the other hand, D-AgNPs showed potent cytotoxicity in the lung cancer cells at the same concentration after 48 hours, whereas D-AuNPs did not exhibit cytotoxicity in both cell lines at the same concentration. However, both D-AgNPs and D-AuNPs at 50 µg/mL enhanced the cytotoxicity of ginsenoside compound K at 25 µM after 48 hours of treatment compared with CK alone. We believe that this rapid green synthesis of D-AgNPs and D-AuNPs is a valuable addition to the applications of D. morbifera medicinal plant. D-AuNPs can be used as carriers for drug delivery and in cancer therapy due to their lack of normal cell cytotoxicity.

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“…The antioxidant and anticancer activities of stem and leaf extracts [10], and the antidiabetic, anticomplement, antiatherogenic, hepatoprotective, and antiinflammatory activities [3,4,6,11,17] of leaf extracts of D. morbifera have been reported. Furthermore, the essential oil extracted from the flowers of this tree has been reported to have larvicidal effects against Aedes aegypti, the mosquito that acts as a vector of dengue fever [5].…”

Section: Introductionmentioning

confidence: 99%

Volatile Compounds and Antiproliferative Effects of Dendropanax morbifera on HepG2 Cells

Yang¹,

Garcia²,

Lee³

2017

Journal of Life Science

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Dendropanax morbifera Lev. is known in Korea for its golden sap and medicinal properties. The many biological activities of the leaf and stem extracts suggest that this tree could be a valuable source of medicinal compounds for the treatment of various ailments such as dermatitis, migraines, dysmenorrhea, muscle pain, and infectious diseases. However, there is little information on the composition and biological activity of the volatile fraction of D. morbifera. Therefore, in this study, the volatile compounds in leaves, stems, and sap of D. morbifera were isolated using solvent and supercritical fluid extraction (SFE), and analyzed by gas chromatography/mass spectrometry to reveal their chemical composition and identify potential compounds of interest. Fifteen compounds were identified in the leaf extracts, whereas 29 and 3 compounds were identified in the stem and sap extracts, respectively. The volatile profiles obtained using solvent and SFE differed. Esters and aromatic hydrocarbons predominated in the solvent extract of leaves and SFE extract of stems, whereas the solvent extract of stems and SFE extract of leaves contained terpenoids. Limonene, α-pinene, and β-myrcene were identified in the volatile extract of sap, with limonene representing 96.30% of the total peak area. In addition, the antiproliferative effects of the solvent extracts of leaves and stems were evaluated, revealing that these solvent extracts were particularly effective in decreasing the proliferation of HepG2 cells.

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Antidiabetic effects of dendropanoxide from leaves of Dendropanax morbifera Leveille in normal and streptozotocin-induced diabetic rats

Cited by 83 publications

References 14 publications

Effects of Climate Change on the Climatic Niches of Warm-Adapted Evergreen Plants: Expansion or Contraction?

Effects of Climate Change on the Climatic Niches of Warm-Adapted Evergreen Plants: Expansion or Contraction?

Rapid green synthesis of silver and gold nanoparticles using<em> Dendropanax morbifera</em> leaf extract and their anticancer activities

Volatile Compounds and Antiproliferative Effects of Dendropanax morbifera on HepG2 Cells

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