Antidiabetic effects and safety profile of chitosan delivery systems loaded with new xanthine-thiazolidine-4-one derivatives: in vivo studies

Constantin, Sandra; Lupașcu, Florentina; Apotrosoaei, Maria; Focsa, Alin; Vasincu, Ioana; Confederat, Luminiţa; Dimitriu, Gabriel; Lupușoru, Cătălina Elena; Routier, Sylvain; Buron, Frédéric; Profire, Lenuța

doi:10.1016/j.jddst.2020.102091

Cited by 7 publications

(5 citation statements)

References 62 publications

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“…) e e 0 (21) where C e (mol/L) is the VO(tpps) concentration in the outer membrane solution at equilibrium; as indicated previously, C 0 , V, and m are the same.…”

Section: Synthesis Of Complex Vo(tpps)mentioning

confidence: 99%

“…Due to its high mucoadhesiveness and minimal production cost, chitosan is frequently used as a carrier for oral therapeutics . Chitosan-based therapeutic strategies are regarded as a viable method for managing diabetes. − …”

Section: Introductionmentioning

confidence: 99%

“… 18 Chitosan-based therapeutic strategies are regarded as a viable method for managing diabetes. 19 − 21 …”

Section: Introductionmentioning

confidence: 99%

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Kinetics, Equilibrium, and Thermodynamics for Conjugation of Chitosan with Insulin-Mimetic [meso-Tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadate(IV)(4−) in an Aqueous Solution

Shaha,

Sarker,

Mahalanobish

et al. 2023

ACS Omega

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This study investigated the conjugation of chitosan with the insulin-mimetic [meso-tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadate(IV)(4−), VO(tpps), in an aqueous medium as a function of conjugation time, VO(tpps) concentrations, and temperatures. To validate the synthesis of chitosan-VO(tpps) conjugate, UV−visible and Fourier transform infrared spectrophotometric techniques were utilized. Conjugate formation is ascribed to the electrostatic interaction between the NH 3 + units of chitosan and the SO 3 − units of VO(tpps). Chitosan enhances the stability of VO(tpps) in an aqueous medium (pH 2.5). VO(tpps) conjugation with chitosan was best explained by pseudo-second-order kinetic and Langmuir isotherm models based on kinetic and isotherm studies. The Langmuir equation determined that the maximal ability of VO(tpps) conjugated with each gram of chitosan was 39.22 μmol at a solution temperature of 45 °C. Activation energy and thermodynamic studies (E a : 8.78 kJ/mol, ΔG: −24.52 to −27.55 kJ/mol, ΔS: 204.22 J/(mol K), and ΔH: 37.30 kJ/mol) reveal that conjugation is endothermic and physical in nature. The discharge of VO(tpps) from conjugate was analyzed in freshly prepared 0.1 mol/L phosphate buffer (pH 7.4) at 37 °C. The release of VO(tpps) from the conjugate is a two-phase process best explained by the Higuchi model, according to a kinetic analysis of the release data. Taking into consideration all experimental findings, it is proposed that chitosan can be used to formulate both solid and liquid insulin-mimetic chitosan-VO(tpps) conjugates.

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“…) e e 0 (21) where C e (mol/L) is the VO(tpps) concentration in the outer membrane solution at equilibrium; as indicated previously, C 0 , V, and m are the same.…”

Section: Synthesis Of Complex Vo(tpps)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Kinetics, Equilibrium, and Thermodynamics for Conjugation of Chitosan with Insulin-Mimetic [meso-Tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadate(IV)(4−) in an Aqueous Solution

Shaha,

Sarker,

Mahalanobish

et al. 2023

ACS Omega

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show abstract

“…Among the tested compounds 34, analogs 34a, 34b, and 34c have significantly reduced the blood glucose level with a significant reduction of OSTT by 7.64%, 7.57%, and 7.97%, respectively. [114] 3. potential. [115] Gummidi et al, reported the synthesis and antidiabetic evaluation of thiadiazole clubbed thiazolidine-4-one hybrids through α-glucosidase and α-amylase inhibition (39, Figure 11).…”

Section: Ptp1bmentioning

confidence: 99%

Section: Thiazolidine‐4‐ones As Promising Antidiabetic Agents (Includ...mentioning

confidence: 99%

A comprehensive review on the antidiabetic attributes of thiazolidine‐4‐ones: Synthetic strategies and structure–activity relationships

Pradhan

Gupta

Kumar

et al. 2022

Archiv der Pharmazie

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The thiazolidine-4-one scaffold has recently emerged as a potential pharmacophore having clinical significance for medicinal chemists. This heterocyclic ring has been reported to possess a plethora of biological activities, including antidiabetic activity that has inspired researchers to integrate this core with different pharmacophoric fragments to design novel and effective antidiabetic leads. The antidiabetic activity has been observed due to the ability of the thiazolidine-4-one nucleus to interact with different biological targets, including peroxisome proliferator-activated receptor γ, protein tyrosine phosphatase 1B, aldose reductase, α-glucosidase, and α-amylase. The present review discusses the mode of action of thiazolidine-4-ones through these antidiabetic drug targets. This review attempts to summarize and analyze the recent developments with regard to the antidiabetic potential of thiazolidine-4-ones covering different synthetic strategies, structure-activity relationships, and docking studies reported in the literature. The significance of various structural modifications at C-2, N-3, and C-5 of the thiazolidine-4-one ring has also been discussed in this manuscript. This comprehensive compilation will provide an inevitable scope for the design and development of potential antidiabetic drug candidates having a thiazolidine-4-one core.

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Chitosan Based Hybrid Polymeric Systems in Diabetes Monitoring

Kaur¹,

Neelam²,

Hajam³

et al. 2023

Biological and Medical Physics, Biomedical Engineering

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Antidiabetic effects and safety profile of chitosan delivery systems loaded with new xanthine-thiazolidine-4-one derivatives: in vivo studies

Cited by 7 publications

References 62 publications

Kinetics, Equilibrium, and Thermodynamics for Conjugation of Chitosan with Insulin-Mimetic [meso-Tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadate(IV)(4−) in an Aqueous Solution

Kinetics, Equilibrium, and Thermodynamics for Conjugation of Chitosan with Insulin-Mimetic [meso-Tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadate(IV)(4−) in an Aqueous Solution

A comprehensive review on the antidiabetic attributes of thiazolidine‐4‐ones: Synthetic strategies and structure–activity relationships

Chitosan Based Hybrid Polymeric Systems in Diabetes Monitoring

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