Antidiabetic Effect of Fenugreek Seed Powder Solution (<i>Trigonella foenum-graecum L</i>.) on Hyperlipidemia in Diabetic Patients

Geberemeskel, Genet Alem; Debebe, Yared Godefa; Nguse, Nigisty Abraha

doi:10.1155/2019/8507453

Cited by 123 publications

(100 citation statements)

References 21 publications

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“…In our meta‐analysis of 15 RCTs (11 with control and 4 without control; Abdel‐Barry et al, 2000; Chevassus et al, 2009; Fedacko et al, 2016; Gaddam et al, 2009; Geberemeskel et al, 2019; Gupta & Gupta, 2001; Kandhare et al, 2018; Kassaian et al, 2009; Kumar et al, 2015; Maheshwari et al, 2017; Moosa et al, 2006; Najdi et al, 2019; Rafraf et al, 2014; Sfar et al, 2018; Yousefi et al, 2017), intake of fenugreek resulted in a significant reduction in TC, TG, and LDL only in studies with control but not in uncontrolled studies. Our results showed that fenugreek consumption has significant positive effect on HDL elevation both in controlled and uncontrolled studies.…”

Section: Discussionmentioning

confidence: 82%

“…Two articles one in Chinese (Shen, Li, Lu, Yu, & Zheng, 2013) and one published before 2000 (Bordia, Verma, & Srivastava, 1997) which did not meet our inclusion criteria were excluded. Finally only 15 articles were selected for meta‐analysis (11 controlled and four uncontrolled; Abdel‐Barry, Abdel‐Hassan, Jawad, & al‐Hakiem, 2000; Chevassus et al, 2009; Fedacko et al, 2016; Gaddam et al, 2009; Geberemeskel, Debebe, & Nguse, 2019; Gupta & Gupta, 2001; Kandhare, Phadke, Mane, Thakurdesai, & Bhaskaran, 2018; Kassaian, Azadbakht, Forghani, & Amini, 2009; Kumar, Kumar, Datta, & Bandyopadhyay, 2015; Maheshwari et al, 2017; Moosa et al, 2006; Najdi, Hagras, Kamel, & Magadmi, 2019; Rafraf, Malekiyan, Asghari‐Jafarabadi, & Aliasgarzadeh, 2014; Sfar et al, 2018; Yousefi et al, 2017) involving 281 cases consumed fenugreek and 255 control cases in controlled group and 136 cases in uncontrolled group.…”

Section: Resultsmentioning

confidence: 99%

“…Sfar et al (2018) in a study on Type 2 diabetic obese women found that fenugreek seeds resulted in increase in HDL‐C and a decrease in LDL‐C levels. Four different studies by Kumar et al (2015), Geberemeskel et al (2019), and Najdi et al (2019) on Type 2 diabetic patients showed that fenugreek improved the lipid profile. In two studies on healthy individuals Maheshwari et al (2017) observed no significant changes in serum lipid profile including TC, TG, HDL‐C, and LDL‐C levels however Fedacko et al (2016) found that the TC, TG, and LDL‐C levels reduced significantly and also HDL‐C increased significantly after fenugreek consumption.…”

Section: Discussionmentioning

confidence: 99%

“…They used articles by Shen et al (2013) (in Chines) and Bordia et al (1997) (before 2000) which were not met our inclusion criteria. However, our meta‐analysis involved six more studies up to December 2019 including Sfar et al (2018), Kandhare et al (2018), Najdi et al (2019), Geberemeskel et al (2019), and to more articles Kumar et al (2015) and Kassaian et al (2009) for T2DM people (controlled and uncontrolled). Considering the number of articles reviewed by our team which is quantitatively higher, our results seems to be more accurate nevertheless, this difference indicates that further studies with better methodology and more detailed results are needed.…”

Section: Discussionmentioning

confidence: 99%

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Effect of fenugreek consumption on serum lipid profile: A systematic review and meta‐analysis

Heshmat-Ghahdarijani

Mashayekhiasl

Amerizadeh

et al. 2020

Phytotherapy Research

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Various studies have shown that Trigonella foenum‐graecum (fenugreek) supplementation has lipid‐lowering activity. This meta‐analysis was performed to evaluate the effect of fenugreek supplementation on human serum lipid profile. Data sources were PubMed, EMBASE, Scopus, and Coherence library which were searched systematically from January 2000 up to December 2019. Inclusion criteria were randomized clinical trial (RCT) study design, at least one of lipid profile components (triglyceride [TG], total cholesterol [TC], low‐density lipoprotein cholesterol, and high‐density lipoprotein cholesterol) levels measured before fenugreek use and one of the lipid components level reported as result. The pooled weighted mean difference (MD) and its 95% confidence interval (CI) were calculated and pooled using a random‐effect model. Only articles published in English were considered. Fifteen RCTs involving 281 cases consumed fenugreek and 255 control cases in controlled group (11 articles) and 136 cases in uncontrolled group (4 articles) were analyzed in our study. Pooled data of indicated a significant impact of fenugreek supplementation on lowering TC (−1.13 [−1.88, −0.37]; p = .003), low‐density lipoprotein (LDL) (−1.26 [−2.09, −0.43]; p = .003), and TG (−1.07 [−1.82, −0.33]; p = 0.005) and increasing the high‐density lipoprotein (HDL) level (0.70 [0.07, 1.34]; p = .03) compared with the control group. There were no significant differences in TC, TG, and LDL between pre‐ and post‐fenugreek studies in the noncontrolled studies however, the result of combination of four studies without control group showed a significant increase in mean HDL (0.81 [0.33,1.29]; p‐value = .001). The results of subgroup analysis showed that the fenugreek reduced the TG and LDL and increases HDL levels in diabetic subjects more effectively. Fenugreek supplementation significantly improved lipid profile (LDL, TG, TC, and HDL). It could be considered as an effective lipid‐lowering medicinal plant. Further high‐quality studies are needed to firmly establish the clinical efficacy of the plant.

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Section: Discussionmentioning

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of fenugreek consumption on serum lipid profile: A systematic review and meta‐analysis

Heshmat-Ghahdarijani

Mashayekhiasl

Amerizadeh

et al. 2020

Phytotherapy Research

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“…Although it is not known exactly how its mechanism occurs, studies suggest that the seed may increase the excretion of bile. This causes the formation of large micelles, compromising the synthesis of triglycerides 10,11 .…”

Section: Medicinal Plants and Diabetesmentioning

confidence: 99%

Use of medicinal plants in the diabetes treatment

2020

JHMR

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Use of medicinal plants in the diabetes treatment Medicinal plants have been used by the population since the beginning as a tool to prevent and fight diseases. In addition, to strengthening local culture and offering cheaper labor, this practice is an alternative to conventional therapies. The use of these plants in metabolic disorders has been studied worldwide. It has shown promising results in reducing glycemic levels and profiles related to diabetes, such as LDL lipid profile, total cholesterol, triglycerides, and glycated hemoglobin (HbA1c). These results can be potential sources for pharmacological treatments, through the production of medicines, as well as the implementation of these plants in the diet, dispensing with the use of commercialized drugs.

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Canadian sainfoin and fenugreek as forage and functional foods

et al. 2020

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Sainfoin (Onobrychis viciifolia Scop.) and fenugreek (Trigonella foenum‐graecum L.) are two legumes that are being developed as forage crops in Canada with potential benefits for animal and human health. Sainfoin, a perennial crop containing condensed tannins (CTs), is gaining popularity in western Canada because of its benefits for cattle. Its CTs make the crop bloat‐free for grazing cattle while improving protein digestibility and reducing greenhouse gas emissions. The CT‐containing fenugreek is also considered as a bloat‐free annual forage legume that was developed to serve in short‐term crop rotations in western Canada. These crops are known to provide health and nutritional benefits to cattle with their high protein content and other beneficial nutraceuticals such as crude fiber, 4‐hydroxyisoleucine, steroid sapogenins, and galactomannans. Some of these nutraceuticals have the potential to benefit human health; however, such attributes have not been studied enough to harness the full potential of these legume crops in Canada. Recent research suggests that legumes are a healthy substitute for meat. However, metabolite analysis of sainfoin is mostly limited to proteins and CTs. The CTs reported in sainfoin are involved in reduction of blood pressure and detoxification and providing anticancer properties in humans. Recent studies on fenugreek have highlighted the beneficial nutraceuticals associated with human health but most of those claims are not backed by relevant clinical studies. In this article, we reviewed the nutritional quality attributes of sainfoin and fenugreek and assessed their potential as functional foods and nutraceuticals for animal and human health based on scientific evidence.

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Antidiabetic Effect of Fenugreek Seed Powder Solution (Trigonella foenum-graecum L.) on Hyperlipidemia in Diabetic Patients

Cited by 123 publications

References 21 publications

Effect of fenugreek consumption on serum lipid profile: A systematic review and meta‐analysis

Effect of fenugreek consumption on serum lipid profile: A systematic review and meta‐analysis

Use of medicinal plants in the diabetes treatment

Canadian sainfoin and fenugreek as forage and functional foods

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