Antidiabetic and Other Therapies Used in Subjects with Diabetes and Chronic Kidney Disease in a Hospital-Based Clinic Population in Greece

Abstract

(1) Background: Type 2 diabetes mellitus (T2DM) is the main cause of chronic kidney disease (CKD). In Greece, in a population from hospital-based diabetes clinics (n = 1759), the overall prevalence of diabetic chronic kidney disease (DCKD) was 45% including mild, moderate, and severe CKD. The aim of this study was to describe and analyze how T2DM patients with mild-to-severe CKD are managed by diabetologists in Greece and assess the achievement rates in glycemic, blood pressure and low-density lipoprotein-cholesterol (LDL-C) control. (2) Methods: This cross-sectional multicenter study took place from June 2015 to March 2016 and collected data from diabetes centers in public hospitals all over Greece. (3) Results: With regard to the anti-diabetes treatment, most participants were on metformin, DPP-4 (Dipeptidyl Peptidase-4 inhibitors) inhibitors and insulin. Angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers were the most prescribed medications for hypertension. For the management of dyslipidemia, most participants were on statins. For patients with DCKD, the levels of HbA1c, blood pressure and LDL-C were 7.2%, 137.7/76.9 mmHg and 95.9 mg/dL, respectively (mean values). (4) Conclusions: The outcomes of this study suggest that management of DCKD can be further improved and should be enhanced. These results may contribute to the whole health care system in Greece. In addition, the better understanding of therapeutic strategies used by diabetologists treating these patients offers educational benefits to primary care physicians, which can result in an overall more successful and efficient management of subjects with T2DM and DCKD.

Hypertriglyceridemia and Other Risk Factors of Chronic Kidney Disease in Type 2 Diabetes: A Hospital-Based Clinic Population in Greece

“…For the management of dyslipidemia, most participants were treated with statins ( n = 1690, 96%), followed by ezetimibe ( n = 181, 10.2%). Details for the administration of antidiabetic, antihypertensive, and lipid-lowering medication were described in a previous publication by our group [ 9 ].…”

Chronic Diabetic Complications: Current Challenges and Opportunities

“…Psillas et al [1] discuss the effects of diabetes mellitus, hypercholesterolaemia and hypertension on Bell's palsy. Migdalis et al [2] provide data on agents used to treat hyperglycemia, hypertension and dyslipidemia in subjects with type 2 diabetes mellitus (T2DM) and chronic kidney disease. Margaritidis et al [3] have shown that Biphasic Insulin Aspart 30 is equally effective to premixed human insulin in controlled subjects with T2DM.…”