Hypertriglyceridemia and Other Risk Factors of Chronic Kidney Disease in Type 2 Diabetes: A Hospital-Based Clinic Population in Greece

Migdalis, Ilias; Ioannidis, Ioannis; Παπάνας, Νικόλαος; Raptis, Athanasios; Sotiropoulos, Alexios; Dimitriadis, George

doi:10.3390/jcm11113224

Cited by 4 publications

(3 citation statements)

References 58 publications

(66 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This investigation was unable to identify any correlation between DKI and blood TG, TC, HDL-C, or LDL-C lipid levels. In most previous studies, high plasma TGs were associated with DKI (12)(13)(14)(15)(16), although a few failed to nd any association (17)(18)(19). High TC levels were associated with DKI in some literature (12,13,16,19,20), while some have not con rmed it (14,17,18).…”

Section: Discussionmentioning

confidence: 95%

The relationship between serum lipid levels and diabetic kidney injury in patients with type 2 diabetes mellitus

Zahedi

Amirkhanlou

Farahani

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Diabetic kidney injury (DKI), a complication of diabetes mellitus (DM) and a risk factor for the cardiovascular events, is affected by many metabolic factors, including dyslipidemia. This study investigated the relationship between serum lipid levels and DKI in patients with type 2 diabetes mellitus (T2DM) in Gorgan, north of Iran. Materials and Methods: This case-control study was performed on 218 patients with T2DM in two groups with and without DKI as case and control groups, respectively. A questionnaire was used to gather demographic information, and the necessary laboratory results, such as fasting serum lipid levels, urine albumin, fasting plasma glucose, and serum creatinine, were also assessed. For group comparison, the Mann-Whitney test, Fisher's exact test, and Chi-square test were used. Results: The results of this study did not show any statistically significant relationship between DKI and serum lipid levels (p>0.05). However, DKI was associated with age, duration of DM, type of glucose-lowering drugs, and body mass index (BMI) (p≤0.05). Discussion and Conclusions: DKI is not significantly related to the serum lipid levels in the patients with T2DM, but older age, longer duration of DM, insulin-indicated hyperglycemia, and lower BMI are associated with it. Therefore, further attention to each of the associated factors may be helpful in the earlier detection of DKI in patients with T2DM.

show abstract

Section: Discussionmentioning

confidence: 95%

The relationship between serum lipid levels and diabetic kidney injury in patients with type 2 diabetes mellitus

Zahedi

Amirkhanlou

Farahani

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…It may be a valuable diagnostic biomarker in early-stage DN due to the elevated levels of ox LDL in patient groups indicating the presence of oxidative stress; however, it is not predictive of renal progression or outcome. Other studies showed that dyslipidemia is associated with the development and progression of diabetic kidney disease [19] .…”

Section: Discussionmentioning

confidence: 98%

Assessment of Autotaxin, Oxidized LDL and β2-Microglobulin in Patients with Diabetic Nephropathy

Farid,

Mahmoud,

Madanay

et al. 2023

International Journal of Medical Arts

View full text Add to dashboard Cite

Article information Background: Diabetes mellitus [DM] is a metabolic condition characterized by hyperglycemia caused by deficiencies in insulin action or secretion or both. Diabetes' persistent hyperglycemia is linked to long-term organ failure, including kidney loss of functions, leading to diabetic nephropathy [DN]. Aim of the work: This study aims to assess the value of serum autotaxin [ATX], oxidized LDL [ox LDL], and β2microglobulin [β2M] as biomarkers for DN patients. Patients and Methods: This cross-sectional study included 100 subjects divided into three groups. Group 1; control group [20 healthy subjects]. Patients were subdivided into two groups, group 2 [40 patients diagnosed with DN stages Ⅰ, Ⅱ, and Ⅲ], and group 3 which involved 40 patients diagnosed with DN stages Ⅳ and Ⅴ.Results: As regards the ATX, it was significantly higher in group 3 than in group 1 and group 2 with a statistically significant difference between every 2 groups [P value > 0.05 for all]. In terms of Ox LDL and β2M, the difference between the three groups was significant statistically [P value = 0.005, and 0.002 respectively], however the difference between group 2 and group 3 was not significant [P value = 0.44, and 0.98 respectively]. Conclusion:Serum autotaxin, ox LDL, and β2M can be used as diagnostic noninvasive biomarkers in DN.

show abstract

“…HTG and inadequate glycemic control elevate the likelihood of chronic kidney disease (CKD) in individuals with type 2 diabetes mellitus ( 33 ). The presence of nephrotic syndrome is associated with a significant reduction in both the abundance and activity of the LPL protein ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

Genetic and clinical characteristics of patients with lipoprotein lipase deficiency from Slovenia and Pakistan: case series and systematic literature review

Ain,

Cevc,

Marusic

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

IntroductionHypertriglyceridemia (HTG) is a complex disorder caused by genetic and environmental factors that frequently results from loss-of-function variants in the gene encoding lipoprotein lipase (LPL). Heterozygous patients have a range of symptoms, while homozygous LPL deficiency presents with severe symptoms including acute pancreatitis, xanthomas, and lipemia retinalis.MethodsWe described the clinical characteristics of three Slovenian patients (an 8-year-old female, an 18-year-old man, and a 57-year-old female) and one Pakistani patient (a 59-year-old male) with LPL deficiency. We performed next-generation sequencing (NGS) targeting all coding exons and intron-exon boundaries of the LPL gene, and Sanger sequencing for variant confirmation. In addition, we performed a systematic literature review of all cases with three identified variants and described their clinical characteristics.ResultsTwo Slovenian patients with a heterozygous pathogenic variant NM_000237.3:c.984G>T (p.Met328Ile) were diagnosed within the first three years of life and had triglyceride (TG) values of 16 and 20 mmol/L. An asymptomatic Pakistani patient with TG values of 36.8 mmol/L until the age of 44 years, was identified as heterozygous for a pathogenic variant NM_000237.3:c.724G>A (p.Asp242Asn). His TG levels dropped to 12.7 mmol/L on dietary modifications and by using fibrates. A Slovenian patient who first suffered from pancreatitis at the age of 18 years with a TG value of 34 mmol/L was found to be homozygous for NM_000237.3:c.337T>C (p.Trp113Arg).ConclusionsPatients with LPL deficiency had high TG levels at diagnosis. Homozygous patients had worse outcomes. Good diet and medication compliance can reduce severity.

show abstract

Hypertriglyceridemia and Other Risk Factors of Chronic Kidney Disease in Type 2 Diabetes: A Hospital-Based Clinic Population in Greece

Cited by 4 publications

References 58 publications

The relationship between serum lipid levels and diabetic kidney injury in patients with type 2 diabetes mellitus

The relationship between serum lipid levels and diabetic kidney injury in patients with type 2 diabetes mellitus

Assessment of Autotaxin, Oxidized LDL and β2-Microglobulin in Patients with Diabetic Nephropathy

Genetic and clinical characteristics of patients with lipoprotein lipase deficiency from Slovenia and Pakistan: case series and systematic literature review

Contact Info

Product

Resources

About