Antidiabetic and antioxidant potentials of Vitellaria paradoxa barks in alloxan-induced diabetic rats

Abstract

Background: Vitellaria paradoxa (V. paradoxa) is a plant used in traditional medicine in the treatment of many diseases including diabetes mellitus. Although the different parts of this plant are used empirically as antidiabetic drug, no scientific work to our knowledge has yet been undertaken to evaluate its effects on blood glucose, and lipid and antioxidant parameters of diabetic animals. The objective of this study is therefore to evaluate the hypoglycaemic, hypolipidemic and antioxidant activities of the aqueous extract of V. paradoxa barks in diabetic rats. Methods: Diabetes was induced by intraperitoneal injection of alloxan (120 mg/kg bw). Thirty male albino rats were divided into groups and orally treated for 14 days with distilled water, glibenclamide (2.5 mg/kg bw) and aqueous extract of V. paradoxa (125, 250 and 500 mg/kg bw). Glycaemia, insulin level, relative body weight, hepatic glycogen level, some liver enzymes, and lipid and antioxidant parameters were evaluated. Results: The results showed that the extract caused a significant increase in relative body weight, insulin level, HDLcholesterol, hepatic glycogen rate, and fructose-1,6-biphosphate and glucokinase activities. A significant decrease in glycaemia, glucose-6-phosphatase activity, total cholesterol, triglycerides and LDL-cholesterol were also observed after the administration of V. paradoxa. Glutathione level and the activities of catalase and superoxide dismutase increased significantly while the nitric oxide and malondialdehyde levels decreased significantly in the liver of animals treated with the extract of V. paradoxa. Conclusion: These results justify the hypoglycaemic, hypolipidemic and antioxidant effects of aqueous extract of V. paradoxa barks, which can reduce the complications associated with diabetes.

The Influence of Plant Extracts and Phytoconstituents on Antioxidant Enzymes Activity and Gene Expression in the Prevention and Treatment of Impaired Glucose Homeostasis and Diabetes Complications

“…Glucose lowering, hypolipidemic, and antioxidant effects were reported for the Vitellaria paradoxa , a medicinal plant used in Africa for diabetes management. Treatment of alloxan-induced diabetic rats for 14 days with aqueous extract of V. paradoxa bark (125, 250 and 500 mg/kg bw, orally) increased the level of GSH and the activities of SOD and CAT enzymes in the liver of diabetic rats, suggesting that V. paradoxa extract may reduce diabetes-associated complications [ 38 ]. By increasing GST activity in H 2 O 2 -treated HepG2 cells, Terminalia chebula fruit ethyl acetate extract also displayed hepatoprotective potential [ 39 ].…”

“… [ 36 ] Vitellaria paradoxa Aqueous extract Liver Alloxan-induced diabetic rats Increases GSH and activities of CAT and SOD. [ 38 ] Terminalia chebula Ethyl acetate extract Liver H 2 O 2 -treated HepG2 cells Increases GST activity. [ 39 ] Annona crassiflora Mart.…”

Hypoglycemic, antidyslipidemic and antioxydant effects of Vitellaria paradoxa barks extract on high-fat diet and streptozotocin-induced type 2 diabetes rats

“…The work carried out by Miaffo et al. [ 10 ] showed the antidiabetic and antioxidant properties of the bark of V. paradoxa in alloxan-induced type 1 diabetes rats. However, no study has been carried out scientifically to prove the antidiabetic effects of the plant on the model of type 2 diabetes.…”

Type 1 diabetes mellitus: therapeutic correction trial with the aqueous extract of the leaves of Tapinanthus dodoneifolius (Loranthaceae)

“…Seventy-two hours (72 h) after induction, their blood glucose was taken at the tail vein using test strips and glucometer (One Touch Ultra Easy) for blood glucose testing. Rats with fasting glucose greater than or equal to 126 mg/dL were considered diabetic and used for the experiment (Miaffo et al, 2019).…”