Antidiabetic and antioxidant activities: Is there any link between them?

Abstract

An empirical relationship between antidiabetic and antioxidant properties of molecules using protocatechuic acid (PcA) as a test compound has been found.

Supramolecular architecture in 1:1 cocrystal of N-carbamothioylacetamide and N,N′-thiocarbonyldiacetamide from the attempted synthesis of 1,3-diacetyl-2-thioxoimidazolidine-4,5-dione (a thioparabanic acid derivative)

“…DFT calculations were carried out on the co-crystal and its oxidized form to obtain its two-electron redox potential ( E 0 ) according to the described procedures [ 23 , 24 , 25 ]. Geometry and frequency calculations were performed at B3LYP/6-311g(d,p) level of theory for both the gas and aqueous phases.…”

“…The computed co-crystal two-electron redox potential (based on catechol) is 530.2 mV, showing that it possesses the highest reducing ability relative to the NCTA and NNTCA, whose one-electron redox potentials are 531.0 and 530.7 mV respectively. It can in addition be inferred from the results that the co-crystal has a significantly lower reducing ability when compared to AA, a known antioxidant with a reported two-electron redox potential of 265.0 mV [ 25 ]. The results also indicate that NNTCA with a lower one-electron E 0 value shows stronger reducing ability than NCTA.…”

“… b One-electron redox potentials in water. c Two-electron redox potential obtained previously for AA [ 25 ]. …”

“…There is a likely possibility that the accidentally synthesized co-crystal being reported here may possess some interesting pharmacological properties. We have also shown these pharmacological tendencies using the molecules' antioxidant properties, which were evaluated from the redox potentials obtained by density functional theory (DFT) calculations [ 23 , 24 , 25 ]. A review on the application of redox potentials to estimate the level of antioxidant activity of organic compounds is available in the literature [ 26 ].…”

Synthesis, In Vitro Evaluation and Molecular Docking of the 5-Acetyl-2-aryl-6-hydroxybenzo[b]furans against Multiple Targets Linked to Type 2 Diabetes

“…Research is in progress to develop drugs with dual antidiabetic and antioxidant properties in an effort to ameliorate diabetes complications. In the meantime, the link between anti-diabetic and antioxidant activities of drugs has been confirmed through in vivo experiments and theoretical calculations using protocatechuic acid and glibenclamide as models [54]. The naturally occurring phenolic derivatives such as hydroxytyrosol, resveratrol and curcumin, for example, have been found to exhibit antidiabetic and antioxidant activities in different ways besides other effects like anti-inflammatory and anti-carcinogenic properties [55].…”