Synthesis, α-glucosidase inhibition and antioxidant activity of the 7-carbo–substituted 5-bromo-3-methylindazoles

Biological evaluation the 2‐aryl‐2,3‐dihydrobenzodiazaborinin‐4(1H)‐ones as potential dual α‐glucosidase and α‐amylase inhibitors with antioxidant properties

“…The α‐glucosidase inhibitory activity of compounds 2a – j was assayed following a method described in our previous study (Mphahlele et al., 2020). The stock solutions of the test compounds (100 µM) prepared in DMSO and acarbose as positive control in DMSO were diluted with 100 mM phosphate buffer to obtain the concentrations 1, 1.5, 5, 10, 25 and 50 µM.…”

“…The DPPH radical scavenging activity of the test compounds 2a – j was evaluated by following a literature method described in our previous study (Mphahlele et al., 2020). Briefly the test compounds and ascorbic acid at various concentrations (1, 5, 10, 25, 50 and 100 µM) in DMSO were mixed with a solution of DPPH (0.20 mM) in methanol and incubated in the dark for 45 min.…”

Quinoline‐fused both non‐peripheral and peripheral ZnIIand MgIIphthalocyanines: Anti‐cholinesterase, anti‐α‐glucosidase, DNA nuclease, antioxidant activities, and in silico studies

“…[ 12 ] α‐Glucosidase, which plays a very important role in the treatment of DM, is located in the epithelial wall of the small intestine and its inhibitors reduce the level of glucose in the bloodstream and is an important enzyme that plays a role in the digestion of carbohydrates. [ 13,14 ]…”

“…[12] α-Glucosidase, which plays a very important role in the treatment of DM, is located in the epithelial wall of the small intestine and its inhibitors reduce the level of glucose in the bloodstream and is an important enzyme that plays a role in the digestion of carbohydrates. [13,14] Theoretical calculations have become very common nowadays. In recent studies, molecular activities are reinforced by comparing theoretical calculations with experimental results.…”

Pyridine substituted BODIPYs: synthesis, characterization and cholinesterease, α-glucosidase inhibitory, DNA hydrolytic cleavage effects

“…Thus, the most effective strategy of DM treatment is to regulate bloodstream glucose levels control [9]. α-Glucosidase inhibitors have important roles to decrease glucose levels in the bloodstream by preventing the breakdown of carbohydrates into absorbable monosaccharides [10]. However, α-glucosidase inhibitors have several side effects such as gastrointestinal disorders, etc [11].…”