Antidiabetic and antilipidemic effect of eremanthin from Costus speciosus (Koen.)Sm., in STZ-induced diabetic rats

Eliza, J.; Daisy, P.; Ignacimuthu, Savarimuthu; Duraipandiyan, Veeramuthu

doi:10.1016/j.cbi.2009.08.012

Cited by 156 publications

(96 citation statements)

References 45 publications

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“…The use of B. discolor at the 600 mg/kg BW dose improved the BW in diabetic rats over the 28 days study period. This increase in the BW of diabetic rats may be attributed to an improvement in insulin secretion and glycemic control (Eliza et al, 2009;Genet et al, 1999). It has also been reported by Rajkumar et al (1997) that increased anabolic reactions may be responsible for weight gain in diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Effect of the methanolic extract of Brachylaena discolor in a streptozotocin-induced diabetic rat model

Mellem¹

2013

Afr. J. Pharm. Pharmacol.

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Traditionally, leaf infusions of Brachylaena discolor are used for the treatment of diabetes and renal conditions. Therefore, the aim of this study was to evaluate the effect of a methanolic leaf extract of B. discolor in a streptozotocin (STZ)-induced diabetic rat model. Diabetes was induced in Wistar rats by an intraperitoneal injection of STZ; blood glucose levels greater than 20 mmol/L measured after 7 days confirmed a stable diabetic mellitus state. Two doses of the test extract (50 and 150 mg/ml) were administered daily via oral dosing to both STZ-induced and control rats. Blood was obtained from the tail vein and used to measure the effects of the extract on the biochemical profile of the rats over 28 days. The methanolic leaf extract of B. discolor at both doses (50 and 150 mg/ml) caused a significant reduction in the blood glucose levels at 7, 14, 21 and 28 days in STZ-induced diabetic rats when compared with the normal rats (negative control). Significant differences were also observed in alkaline phosphatase, creatinine, total bilirubin and body weights of extract treated diabetic rats when compared with untreated diabetic rats, normal rats and metformin treated rats. Findings suggest that B. discolor exhibits significant anti-hyperglycaemic activity in STZ-induced diabetic rats.

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Section: Discussionmentioning

confidence: 99%

Effect of the methanolic extract of Brachylaena discolor in a streptozotocin-induced diabetic rat model

Mellem¹

2013

Afr. J. Pharm. Pharmacol.

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“…AST and ALT are considered as liver toxicity markers [41] . The increase in the activities of liver and kidney AST and ALT indicated that diabetes may induce hepatic dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Effect of Commiphora mukul gum resin on hepatic marker enzymes, lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats

Ramesh

Rasineni

Sreenivasa

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…17.Combining Al-hijamah with oral honey or sea costus as recommended treatments in prophetic medicine [82] Oral honey and costus are other curative remedies recommended by prophetic medicine, especially for treating diabetes mellitus. [116] Both oral honey and costus are mentioned in the same prophetic hadeeth (sayings) with Al-hijamah. Combinatory effects of both will expand the therapeutic spectrum of Al-hijamah.…”

Section: Nbmentioning

confidence: 95%

Therapeutic Benefits of Al-hijamah: in Light of Modern Medicine and Prophetic Medicine

Sayed¹,

Al-quliti²,

Mahmoud³

et al. 2014

AJMBR

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Excretory treatment modalities that excrete pathological substances outside human body deserve more research attention as this may potentiate the therapeutic effects of pharmacological treatments. Overcoming language barrier through translating the national medical literature to medical English to be introduced to the international medical literature is vital. Wet cupping therapy (WCT) of prophetic medicine (Al-hijamah) is practiced in the Arabic medical literature where it is reported to treat many diseases differing in etiology and pathogenesis. Al-hijamah may be referred to as bloodletting cupping therapy or blood cupping therapy in medical studies and reports from Arabic countries. Both Chinese dry cupping therapy and WCT are partial steps of Al-hijamah. In this article, we review scientific principles, methodology, indications and therapeutic benefits of Al-hijamah in comparison with acupuncture and other types of cupping therapy. Scientific and medical bases of Al-hijamah were recently reported in the evidence-based Taibah mechanism (Taibah theory) where Al-hijamah is the only excretory treatment that clears blood, lymph and intercellular fluids from causative pathological substances (CPS). Al-hijamah benefits from the histological structure of the skin in performing a percutaneous pressure-dependent and size-dependent nonspecific blood filtration and excretion of CPS through the fenestrated skin capillaries upon application of negative pressure suction using sucking cups. Al-hijamah benefits also from the production of endogenous nitric oxide (vasodilator, antineoplastic and antimicrobial agent). Al-hijamah exerts many other health benefits e.g. enhancement of immunity and pharmacological potentiation. Al-hijamah was reported to clear blood significantly from serum triglycerides, total cholesterol, LDL-cholesterol, ferritin (circulating iron stores), uric acid, autoantibodies, cytokine receptors and others. Those therapeutic benefits may treat some diseases e.g. hyperlipidemia, hypertension, atherosclerosis, coronary heart diseases, gout, musculoskeletal pain conditions, hepatitis and iron overload conditions e.g. thalassemia. Importance of Al-hijamah may increase more in modern societies due to western diets and western life style. Therapeutic benefits of Al-hijamah are mainly related to the amount of excreted CPS not the amount of letted blood. Al-hijamah may carry some advantages better than acupuncture and other types of cupping therapy in treating a large number of diseases differing in etiology and pathogenesis.

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Antidiabetic and antilipidemic effect of eremanthin from Costus speciosus (Koen.)Sm., in STZ-induced diabetic rats

Cited by 156 publications

References 45 publications

Effect of the methanolic extract of Brachylaena discolor in a streptozotocin-induced diabetic rat model

Effect of the methanolic extract of Brachylaena discolor in a streptozotocin-induced diabetic rat model

Effect of Commiphora mukul gum resin on hepatic marker enzymes, lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats

Therapeutic Benefits of Al-hijamah: in Light of Modern Medicine and Prophetic Medicine

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