Antidiabetic and antihyperlipidemic effects of crude fractions and isolated compound from Striga orobanchioides Benth on streptozotocin induced diabetic rats

Vikhe, Sunayana; Kunkulol, Rahul; Raut, Dipak

doi:10.1016/j.jaim.2022.100618

Cited by 8 publications

(5 citation statements)

References 23 publications

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“…Docking studies predicted that these triterpenoids, and the related β-amyrin, could be GK allosteric activators, but showed different interaction pattern than flavonoids. 220 The predominant observed interactions were hydrophobic. 235 The tetranortriterpenoid meliacinolin ( 311 ), daily administered for 28 days at a dose of 4 mg kg −1 , increased both insulin and glycogen levels (17.86 ± 1.98 mg per g tissue and 3.34 ± 0.42 μU mL −1 , respectively) when compared with STZ-diabetic controls (9.25 ± 1.65 mg per g tissue and 1.42 ± 0.18 μU mL −1 , respectively) and in a similar fashion than glibenclamide, used as positive cotrol.…”

Section: Glucokinase Activatorsmentioning

confidence: 99%

“…Betulin ( 309 ), 220 as well as 18β-glycyrrhetinic ( 307 ), 218 asiatic ( 308 ), 219 ursolic ( 332 ), 234 and oleanolic ( 310 ) 221 acids augmented GK activation and increased glycogen levels in diabetic rodents. Compounds 307 and 308 induce a significant augmentation of insulin levels, whilst triterpenoid 310 activated GK in a similar manner as insulin (used as positive control).…”

Section: Glucokinase Activatorsmentioning

confidence: 99%

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Natural products from plants targeting key enzymes for the future development of antidiabetic agents

et al. 2023

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Section: Glucokinase Activatorsmentioning

confidence: 99%

Section: Glucokinase Activatorsmentioning

confidence: 99%

Natural products from plants targeting key enzymes for the future development of antidiabetic agents

et al. 2023

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“…Polyherbal drugs comprising of two or more medicinal plants are considered to be effective and safe natural therapeutics for many diseases (Suvarna et al 2023; Vikhe et al 2022). Over the years studies investigating antidiabetic activities of polyherbal drugs have been rising (Gopalakrishnan et al 2020; Wanjari et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition by PTP 1B inhibitory activity guided analysis of plant-based antidiabetic polyherbal drug used in ethnomedical systems

Dzomba,

Mugari,

Nyoni

2024

Preprint

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Background Due to growing resistance and continued depletion of drugs that can be used as replacements, people turn to herbal medicines. A polyherbal drug was studied to investigate its chemical composition and possible mode of action. Methods Phytochemicals were isolated using Column and Thin Layer Chromatography, and antidiabetic activity was ascertained using an enzyme inhibition model. Active compounds identity was established using 1HNMR, 13CNMR, HSQC-NMR, UV, FT-IR and MS spectroscopy. Results Results showed that the polyherbal drug consisted of alkaloids and anthocyanins as the major active components. The alkaloids PTP 1B inhibition was not significantly different from that of metformin with percentage inhibition of Alkaloid 1, 78.6 ± 3.2% and Alkaloid 2, 79.6 ± 2.3. The anthocyanins inhibited PTP 1B enzyme significantly better than metformin with percentage inhibition of Flavonoid 1, 88.2 ± 3.2, Flavonoid 2, 90.3 ± 2.3 and Flavonoid 3 93.6 ± 2.9. One new alkaloid compound, Alkaloid 1, 1, 2-dimethoxy-12-methyl-7-(3-methylbut-2-en-1-yl)-12, 13-dihydro[1,3]benzodioxolo[5,6-c]phenanthridin-13-ol, one previously reported alkaloid, Alkaloid 2 berberine, IUPAC name, 9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4',5':6,7]isoquinolino[2,1-b][2]benzazin-7-ium and three anthocyanins, Flavonoid 1, malvidin 3-o-glucoside, Flavonoid 2, pelargonidin-3-O-gucoside and Flavonoid 3 malvidin 3, 5-O-diglucoside were identified as the active compounds in the polyherbal drug extract. Conclusion Presence of alkaloids and anthocyanins that have PTP 1B inhibitory activity showed that the polyherbal drug is a potential medicine for managing diabetes.

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“…There are several advantages associated with using plants and plant phytoconstituents as opposed to pharmaceutical products. Plant extracts and phytoconstituents have been shown to have biological properties, such as antidiabetic [ 12 ], antihyperlipidemic [ 13 ], free radical scavenging [ 14 ], and anti-inflammatory properties [ 15 , 16 ]. It has been established that dietary patterns (DPs) that increase the risk of metabolic and cardiovascular disorders also significantly increase the risk of dementia [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Compounds of the Mediterranean Diet as Nutritional Support to Fight Neurodegenerative Disease

Franco

Interdonato

Cordaro

et al. 2023

IJMS

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Neurodegenerative disorders are a widespread cause of morbidity and mortality worldwide, characterized by neuroinflammation, oxidative stress, and neuronal depletion. They include selective malfunction and progressive loss of neurons, glial cells, and neural networks in the brain and spinal cord. There is an urgent need to develop new and more effective therapeutic strategies to combat these devastating diseases because, today, there is no treatment that can cure degenerative diseases; however, we have many symptomatic treatments. Current nutritional approaches are beginning to reflect a fundamental change in our understanding of health. The Mediterranean diet may have a protective effect on the neurodegenerative process because it is rich in antioxidants, fiber, and omega-3 polyunsaturated fatty acids. Increasing knowledge regarding the impact of diet on regulation at the genetic and molecular levels is changing the way we consider the role of nutrition, resulting in new dietary strategies. Natural products, thanks to their bioactive compounds, have recently undergone extensive exploration and study for their therapeutic potential for a variety of diseases. Targeting simultaneous multiple mechanisms of action and a neuroprotection approach with the diet could prevent cell death and restore function to damaged neurons. For these reasons, this review will be focused on the therapeutic potential of natural products and the associations between the Mediterranean-style diet (MD), neurodegenerative diseases, and markers and mechanisms of neurodegeneration.

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Antidiabetic and antihyperlipidemic effects of crude fractions and isolated compound from Striga orobanchioides Benth on streptozotocin induced diabetic rats

Cited by 8 publications

References 23 publications

Natural products from plants targeting key enzymes for the future development of antidiabetic agents

Natural products from plants targeting key enzymes for the future development of antidiabetic agents

Chemical composition by PTP 1B inhibitory activity guided analysis of plant-based antidiabetic polyherbal drug used in ethnomedical systems

Bioactive Compounds of the Mediterranean Diet as Nutritional Support to Fight Neurodegenerative Disease

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