Antidiabetic and Antihyperlipidemic Effects of Ethanol Extract of <i>Rosa canina</i> L. fruit on Diabetic Rats

Taghizadeh, Mohsen; Rashidi, Ali Akbar; Taherian, Aliakbar; Vakili, Zarichehr; Sajadian, Mohammad Sajad; Ghardashi, Mostafa

doi:10.1177/2156587215612626

Cited by 40 publications

(25 citation statements)

References 22 publications

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“…These results were also confirmed by Taghizadeh et al (2016) who found that the administration of Rosa canina extract in STZ-induced diabetic rats at a dose of 250 mg/kg body weight significantly decreased the levels of serum triglycerides whereas serum cholesterol, low-density lipoprotein, and high-density lipoprotein levels were not modified [134]. …”

Section: Rose Hip and Diseasesupporting

confidence: 72%

“…These results were supported by Orhan et al [133], who found that R-H 2 O fraction of Rosa canina fruits reduced blood glucose level significantly in streptozotocin (STZ)-induced diabetic rats (50–62%) and demonstrated the hypoglycemic effect of Rosa canina in an animal model of diabetes mellitus. Moreover, histopathological studies of organs from STZ-induced diabetic rats revealed that low doses of Rosa canina extract (250 mg/kg body weight) significantly increased the number of islets in comparison with diabetic rats of the control group and improved the histology of necrotic islets of pancreas [134]. This effect was not associated with the phenolic content Rosa canina —which is mainly contained in ethanol and methanol extracts—but with different bioactive compounds such as vitamin B and C, carotene, organic acids, flavonoids, tannins, monosaccharides, oligosaccharides, and pectins contained in the polar extract [135].…”

Section: Rose Hip and Diseasementioning

confidence: 99%

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Therapeutic Applications of Rose Hips from Different Rosa Species

Mármol

Sánchez-de-Diego

Jiménez-Moreno

et al. 2017

IJMS

137

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Rosa species, rose hips, are widespread wild plants that have been traditionally used as medicinal compounds for the treatment of a wide variety of diseases. The therapeutic potential of these plants is based on its antioxidant effects caused by or associated with its phytochemical composition, which includes ascorbic acid, phenolic compounds and healthy fatty acids among others. Over the last few years, medicinal interest in rose hips has increased as a consequence of recent research that has studied its potential application as a treatment for several diseases including skin disorders, hepatotoxicity, renal disturbances, diarrhoea, inflammatory disorders, arthritis, diabetes, hyperlipidaemia, obesity and cancer. In this review, the role of different species of Rosa in the prevention of treatment of various disorders related to oxidative stress, is examined, focusing on new therapeutic approaches from a molecular point of view.

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Section: Rose Hip and Diseasesupporting

confidence: 72%

Section: Rose Hip and Diseasementioning

confidence: 99%

Therapeutic Applications of Rose Hips from Different Rosa Species

Mármol

Sánchez-de-Diego

Jiménez-Moreno

et al. 2017

IJMS

137

View full text Add to dashboard Cite

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“…Wyniki te zostały również potwierdzone przez Taghizadeha i wsp. [41], którzy wykazali, że podawanie ekstraktu z dzikiej róży szczurom z cukrzycą indukowaną streptozotacyną w dawce 250 mg/kg masy ciała znacząco obniżało poziomy triglicerydów w surowicy, podczas gdy poziom cholesterolu w surowicy pozostał bez zmian [41].…”

Section: Działanie Przeciwhiperlipidemiiunclassified

Rose hip (Rosa canina L.) as a vitamin and antioxidants source in human diet

Kaszuba¹,

Viapiana²,

Wesołowski³

2019

Farm Pol.

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R óża intrygowała ludzkość od niepamiętych czasów swym zapachem, pięknem i walorami użytkowymi. Obecna była w kulturze, malarstwie, literaturze, a nawet w religii. Szczególnym uznaniem cieszyła się w starożytności. W Egipcie różę poświęcono bogini płodności Izydzie, uwieczniano ją na ścianach grobowców, zaś korony z kwiatów, zwane "świętymi różami abisyńskimi", stanowiły część wyposażenia zmarłych. W Grecji róża stała się symbolem Afrodyty. Uważano, że powstała z tej samej piany morskiej, co bogini miłości. Grecy opiewali różę w poematach, np. Safona nazywała ją królową kwiatów. Starożytni rzymianie cenili różę jako roślinę ozdobną; słynęli oni z zamiłowania do zrzucania jej płatków z sufitu podczas uczt, tworząc tym samym "kwiatowy deszcz". Ponadto, w rzymskim menu można było odnaleźć różane budynie, nalewki i afrodyzjaki, a także lekarstwa sporządzone na bazie kwiatów róży. Jak by tego było mało, obchodzono specjalne święto Rosalia, ku powszechnemu uwielbieniu dla tych kwiatów. Wodą różaną napełniano publiczne łaźnie i fontanny cezarów, gdy tymczasem w starożytnym Izraelu używano ją do obmywania ścian Świątyni Jerozolimskiej. W średniowieczu tworzono ogrody różane, które służyły jako miejsca pochówku. W czasach współczesnych spożywanie dzikiej róży jest szczególnie popularne w krajach skandynawskich, chociaż także w wielu krajach europejskich, takich jak Polska, Portugalia, Niemcy, również cieszy się to uznaniem. Owoce dzikiej róży są wykorzystywane głównie jako składniki deserów, ciast, chleba, galaretek, marmolad, lodów, zup, syropów, herbat i innych napojów [1]. Oprócz przemysłu spożywczego, także przemysł farmaceutyczny i kosmetyczny korzysta z tego surowca. Rodzaj Rosa L. obejmuje ponad 100 gatunków krzewów i pnączy, a dokładna ich liczba jest trudna do ustalenia ze względu na różne ujęcia Rose hip (Rosa canina L.) as a vitamin and antioxidants source in human diet • Rose hip is a rich source of bioactive compounds for health benefits, especially vitamins and polyphenolic compounds. For this reason, the aim of the work was to give the basic information on chemical composition and biological activity of this plant. The wide range of medical application of rose hip, such as anti-diabetic, anti-inflammatory, anticancer and many other biological activities has also been characterized in this paper. Moreover, the application of rose hip in cosmetic industry has been mentioned.

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“…Therefore, the hypoglycemic activity of a number of plant extracts has been evaluated and confirmed in animal models [8][9][10]. Many recent studies have revealed that plant-based formulations can contribute to a better management of diabetes, as certain phytochemicals exert antioxidant, anti-inflammatory, and glucose-lowering effects [10][11][12][13]. In Vietnam, Adenosma bracteosum Bonati.…”

Section: Introductionmentioning

confidence: 99%

Potential Antidiabetic Activity of Extracts and Isolated Compound from Adenosma bracteosum (Bonati)

et al. 2020

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Adenosma bracteosum Bonati. (A. bracteosum) has been used in traditional and modern medicine in Vietnam for curing hepatitis. In this study, ethanol and aqueous extracts of A. bracteosum were evaluated for their α-glucosidase inhibitory activities and anti-hyperglycemic effects on glucose loaded hyperglycemic and streptozotocin (STZ) induced diabetic mice. The α-glucosidase inhibition of the extracts was evaluated by colorimetric assays, and the anti-diabetic activity was tested on a STZ-induced diabetic mice model. The ethanol and aqueous extracts showed a significant α-glucosidase inhibitory activity, which was more effective than acarbose at the same concentration. In the STZ-induced diabetic mice, both extracts showed a strong anti-hyperglycemic activity, with the group receiving 50 mg/kg of ethanol extract and the group receiving 50 mg/kg of aqueous extract presenting 64.42% and 57.69% reductions, respectively, in the blood glucose levels when compared with the diabetic control group, on day 21 (p > 0.05). Isoscutellarein-8-O-β-D-glucopyranoside (IG) was identified from the ethanol extract, which showed a strong inhibitory activity against α-glucosidase, with a ten times higher potency compared with the positive control acarbose. The anti-hyperglycemic effect of IG was effectively similar to the standard drug, glibenclamide, at the same dose of 10 mg/kg (p > 0.05). These results indicated that A. bracteosum has a great antidiabetic potential.

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Antidiabetic and Antihyperlipidemic Effects of Ethanol Extract of Rosa canina L. fruit on Diabetic Rats

Cited by 40 publications

References 22 publications

Therapeutic Applications of Rose Hips from Different Rosa Species

Therapeutic Applications of Rose Hips from Different Rosa Species

Rose hip (Rosa canina L.) as a vitamin and antioxidants source in human diet

Potential Antidiabetic Activity of Extracts and Isolated Compound from Adenosma bracteosum (Bonati)

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