Antidiabetic and Anticoagulant Properties of Heparin–Glutamic Acid Complex

Preparation and anticoagulation activity of sodium cellulose sulfate

“…Na-MCS can prolong APTT and TT, but not PT even at a high concentration, which agreed with the published data about anticoagulation activities for sulfated pullulans, fucans, and other sulfated polysaccharides [1,5]. The prolonging of APTT suggests the inhibition of an intrinsic and/or common pathway, whereas the prolongation of TT indicates inhibition of thrombin activity or fibrin polymerization [17]. No effect of Na-MCS on PT shows that it does not inhibit extrinsic pathway of coagulation.…”

Recovery of bioactive compounds in kiwifruit juice by ultrafiltration

“…Glutamic acid alone, and particularly in complex with heparin, has a considerable antidiabetic and anticoagulant property (Ul'yanov, Lyapina, Pastorova, & Smolina, 2004).…”

Anticoagulant Effects of a Complex of High Molecular Weight Heparin and Arginine

“…One of the natural anticoagulants of the hemostasis system, heparin, blocks the clotting activity of thrombin [6] and in parallel with this, exhibits hypolipidemic, hypoglycemic, and antiinflammatory effects. Experimental data, confirmed clinically, indicate amplification of the anticoagulant and antidiabetogenic effects of heparin complexes with some low molecular-weight substances [3,5,10].…”