Anticoagulant Effects of a Complex of High Molecular Weight Heparin and Arginine

Abstract

Heparin forms a complex compound with arginine in a pure system, which was shown by biochemical methods. A method for obtaining the complex in vitro has been developed. At arginine/heparin molar ratio of 3:1 the complex exhibited anticoagulant, antiplatelet, and fibrin-depolymerization activities. High fibrin-depolymerization and anticoagulant activities were documented in the blood of animals 10 min after intravenous injection of the arginine-heparin complex, in contrast to the picture after injection of the complex components (heparin and arginine) alone.

Management considerations for stroke-like episodes in MELAS with concurrent COVID-19 infection

“…The decision was made to delay initiation of anti-coagulation in this case because concurrent use of heparin and IV arginine posed a theoretical risk for bleeding. As discussed before, IV arginine causes vasodilation and systemic hypotension via release of nitric oxide and can have an inhibitory effect on hemostasis [8,9]. After the initial bolus, the infusion was continued for 2 days.…”