Antidiabetic activity of mefloquine via GLP-1 receptor modulation against STZ–NA-induced diabetes in albino wistar rats

Abstract

Mefloquine was retrieved as a glucagon -like peptide-1 receptor agonist and, therefore, evaluated for its antidiabetic potential against non-insulin-dependent diabetes mellitus (NIDDM) in experimental animals. NIDDM was induced by single intraperitoneal injection of streptozotocin and nicotinamide (60 + 110 mg/kg) in albino wistar rats. The experimental animals were scrutinised for electrocardiographic (ECG) and heart rate variability (HRV) factors to study the autonomic dysfunction along with blood glucose, serum insulin, and liver glycogen levels for glycemic control. Simultaneously, antioxidant markers (TBARs, protein carbonyl, GSH, SOD, catalase) and inflammatory markers (COX, LOX, NO) were scrutinized as well. Oral administration of mefloquine normalised the heart rate with favourable regulation of time and frequency domain HRV parameters. Mefloquine restored the blood glucose, serum insulin, and liver glycogen levels favourably in diabetic rats. Treatment with mefloquine curtailed the antioxidant markers with favourable regulation of inflammatory signals. Mefloquine was also found to be less hepatotoxic in contrast to the standard metformin, providing an integrated advantage as an antidiabetic agent.

Effect of Voacamine upon inhibition of hypoxia induced fatty acid synthesis in a rat model of methyln-nitrosourea induced mammary gland carcinoma

“…Autodock 4.2 was used to determine the strength of interaction between various ligands and targets in combination with 3D visualization. Ligands structure was searched from the ZINC database, and protein structure was searched from Protein Data Bank (PDB id-2G19) [ 43 , 44 ]. A library of 5000 natural compounds from natural origin was downloaded based on their 60% structure similarity with Vincristine from the ZINC database.…”

The Autonomic Nervous System, Sex Differences, and Chronobiology under General Anesthesia in In Vivo Experiments Involving Rats

“…Similar results have been reported in previous studies. Administration of the anesthetic agent tribromoethanol in male Wistar rats [66], ketamine hydrochloride and diazepam in albino Wistar rats [67], and ketamine/xylazine and pentobarbital in females [59] resulted in predominant parasympathetic activity. However, our results indicate that precisely defining changes in HRV are difficult due to significant variability, which in turn makes it difficult to attribute sex differences.…”

“…5(165.6-171.5), n = 3) [7,30,31]; pent -Pentobarbital (161. 1(156.1-165.7), n = 6) [32][33][34][35][36][37]; , n = 5) [38][39][40][41][42]; , n = 1) [43]; , n = 4) [44][45][46][47]; Uret -Urethane (187. 5(183.7-191.2), n = 2) [48,49]; zoletil -Zoletil anesthesia (145.05(136.…”

Rat Electrocardiography and General Anesthesia

“…The effect of phenobarbital [95], ketamine/medetomidine [96], ketamine/midazolam [97], and ketamine/diazepam [96,98] on anesthesia could not be assessed as valid because there was only one study.…”