Antidiabetic activity of levan polysaccharide in alloxan-induced diabetic rats

Vildagliptin Ameliorates Oxidative Stress and Pancreatic Beta Cell Destruction in Type 1 Diabetic Rats

“…Our data show that the pancreas of diabetic animals has increased oxidative damage, exemplified by the increased concentration of TBARS. Several studies also showed an increase in the concentration of TBARS in the pancreatic tissue of diabetic rats (43,45,46). However, animals treated with 5 mg/kg vildagliptin showed significantly decreased concentrations of TBARs compared to untreated diabetic animals ( Figure 2).…”

Antioxidant activities of polysaccharides from Lentinus edodes and their significance for disease prevention

“…The therapeutic properties of mushrooms result from the specific polysaccharides that have slight or no side effects. Growing evidence had repeatedly confirmed mushroom polysaccharides via oral ingestion on the prevention and treatment of human disease, which not only could effectively reduce lipid peroxidation, blood glucose and blood lipids levels in diabetic rats or patients [22][23][24][25][26], but also prevent the accumulation of serum triaclyglycerols, thus decreasing the risk of developing cardiovascular disease [27].…”

Polysaccharide isolated from Triticum aestivum stimulates insulin release from pancreatic cells via the ATP-sensitive K+ channel

“…Since numerous bioactive polysaccharides isolated from herbal plants have been shown to have antidiabetic effects, they are becoming attractive materials for additional pharmaceutical products. Generally, the dietary supplements containing high levels of water soluble polysaccharides, such as soluble fiber and β-glucan, are effective in improving serum lipid levels, blood glucose levels, and insulin resistance (9)(10)(11) (12,13). We previously have shown that the aqueous extracts of Triticum aestivum sprout (TASP) attenuated blood glucose level in the streptozotocin (STZ)-induced diabetic mice, which is an animal model of human insulin-dependent type 1 diabetes (14).…”