Antidiabetic Activity of Indian Medicinal Plants

Rani, Vibha; Gupta, Anubhuti; Megha,; Awasthi, Sakshi; Suneja, Tanya; Yadav, Mohini; Verma, Shanya

doi:10.1007/978-981-13-7248-3_11

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…Our previous study reported that PHF contains plentiful phytochemicals, 11 and earlier other studies demonstrated that phytochemicals are accountable for the exciting insulin from the existing pancreatic b cells. 16,17 The present study further offered substantiation of the cardioprotective potential of PHF by determining the circulating markers of cardiac function like troponin T, CK-MB, LDH, and AST in serum. In the current study, there was a momentous rise in levels of troponin T and activities of CK-MB, LDH, and AST in serum of DCM rats when compared with the normal control group (group 1).…”

Section: Discussionmentioning

confidence: 62%

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Polyherbal Formulation Ameliorates Diabetic Cardiomyopathy Through Attenuation of Cardiac Inflammation and Oxidative Stress Via NF-κB/Nrf-2/HO-1 Pathway in Diabetic Rats

Uddandrao

Parim

Sengottuvelu

et al. 2022

Journal of Cardiovascular Pharmacology

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The present study was intended to evaluate the effect of polyherbal formulation (PHF) made with 3 nutraceuticals, such as Piper nigrum, Terminalia paniculata, and Bauhinia purpurea on inflammation and oxidative stress in diabetic cardiomyopathy (DCM), which is induced by streptozotocin and nicotinamide administration in rats. We supplemented DCM rats with PHF (250 and 500 mg/kg/BW) for 45 days and evaluated their effects on oxidative stress markers, proinflammatory cytokines, and messenger RNA expressions of the nuclear factor erythroid 2-related factor-2 (Nrf-2) and its linked genes [heme oxygenase-1 (HO-1), superoxide dismutase, catalase] along with inflammatory genes [tumour necrosis factor a and nuclear factor kappa B (NF-kB)]. Our study demonstrated that PHF successfully attenuated inflammation and oxidative stress via messenger RNA upregulation of Nrf-2, HO-1, superoxide dismutase, and catalase and concomitantly with downregulation of tumour necrosis factor a and NF-kB. Conversely, PHF also protected hyperglycemia-mediated cardiac damage, which was confirmed with histopathological and scanning electron microscopy analysis. In conclusion, our results suggested that PHF successfully ameliorated hyperglycemia-mediated inflammation and oxidative stress via regulation of NF-kB/Nrf-2/HO-1 pathway. Therefore, these results recommend that PHF may be a prospective therapeutic agent for DCM.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Polyherbal Formulation Ameliorates Diabetic Cardiomyopathy Through Attenuation of Cardiac Inflammation and Oxidative Stress Via NF-κB/Nrf-2/HO-1 Pathway in Diabetic Rats

Uddandrao

Parim

Sengottuvelu

et al. 2022

Journal of Cardiovascular Pharmacology

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“…As per WHO, approximately 90% of the diabetic patients from developing countries primarily rely on the plants and their products for the management of diabetes mellitus 41,42 . Also, there are about 21,000 medicin1al plants species available across the world out of which about 2500 plant species have been reported from India 45 .…”

Section: Herbal Remedymentioning

confidence: 99%

Review on Plants for Management of Diabetes in India: An Ethno- Botanical and Pharmacological Perspective

Dixit¹,

Tiwari²

2020

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The diagnosis of early diabetes includes Glycosylated Haemoglobin (HbA1C), Glucose Tolerance Test (GTT), Fasting Plasma Glucose (FPG), Postprandial Plasma Glucose (PPG) test 16 . GTT helps to diagnose gestational diabetes, pre-diabetes, insulin resistance or reactive hypoglycemia. FPG & PPG level reflect the state of recent glycemia, whereas HbA1c level reflects chronic glycaemia. As per American Diabetes Association (ADA), HbA1c should be less than 7% ABSTRACT Background: Diabetes mellitus is a prevalent chronic disease, which is recognized as a common threat to health in the last decade, especially in Asia. It is a lifestyle disease which may cause a number of complications in the body of humans like cardiac failure and dysfunctioning of urinary tract. Materials and Methods: The data is obtained from various search tools and electronic databases like, scientific literature, Google scholar, Google, Pubmed, Web of science and Scopus. Results: Major therapy for diabetes is insulin, oralantidiabetic drugs, and herbal treatment. However, insulin and oral anti-diabetic drugs come with a number of side effects and cannot be afforded by people with below poverty line. The herbal medicines have performed a satisfactory clinical practice for the management of diabetes mellitus. Moreover, pharmacological & phytochemical screening of medicinal plants has also witnessed the hypoglycaemic effects of these plants in treating diabetes mellitus. Majority of the modern drugs like metformin, atropine, digitalis, etc. are also originated from plants. Conclusion: The current paper presents a review of medicinal plants used for diabetes management in India. The therapeutic potential, ethnobotanical use, and their pharmacological evaluations are highlighted for harnessing the anti-diabetic potential of these plants by the Indian healthcare system.

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Investigation of the protective effect of gel incorporating Eugenia jambolana leaf extract on 5-fluorouracil-induced oral mucositis: an animal study

Aksoy

Şen

Sukmasari

et al. 2022

J Cancer Res Clin Oncol

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Antidiabetic Activity of Indian Medicinal Plants

Cited by 3 publications

References 27 publications

Polyherbal Formulation Ameliorates Diabetic Cardiomyopathy Through Attenuation of Cardiac Inflammation and Oxidative Stress Via NF-κB/Nrf-2/HO-1 Pathway in Diabetic Rats

Polyherbal Formulation Ameliorates Diabetic Cardiomyopathy Through Attenuation of Cardiac Inflammation and Oxidative Stress Via NF-κB/Nrf-2/HO-1 Pathway in Diabetic Rats

Review on Plants for Management of Diabetes in India: An Ethno- Botanical and Pharmacological Perspective

Investigation of the protective effect of gel incorporating Eugenia jambolana leaf extract on 5-fluorouracil-induced oral mucositis: an animal study

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