Antidiabetic activity of a standardized extract (Glucosol™) from Lagerstroemia speciosa leaves in Type II diabetics

Judy, William V.; Hari, Siva P.; Stogsdill, W. W.; Judy, Janet; Naguib, Yousry M. A.; Passwater, Richard A.

doi:10.1016/s0378-8741(03)00122-3

Cited by 121 publications

(67 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1), a compound which prevents oxidative stress, inflammation, hypertension and so on ( 1 ). The hypoglycemic effect of CA has been reported by various experiments (2)(3)(4)(5). The decrease in insulin resistance due to the increase in GLUT4 translocation has been reported as a mechanism of action ( 6 ).…”

mentioning

confidence: 99%

Effect of Corosolic Acid on the Hydrolysis of Disaccharides

Takagi

Miura

Ishibashi

et al. 2008

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

SummaryThe banaba leaf ( Lagerstroemia speciosa L.) has been used in traditional Oriental medicine to treat diabetes in the Philippines. It contains corosolic acid (CA), a compound which has a hypoglycemic effect. We examined the effect of CA on blood glucose levels and the hydrolysis of disaccharides in the small intestine in mice. CA (10 mg/kg body weight) improved hyperglycemia after an oral administration of sucrose, and significantly reduced the hydrolysis of sucrose in the small intestine. These results suggest that the hypoglycemic activity of CA is derived, at least in part, due to the inhibition of the hydrolysis of sucrose.

show abstract

mentioning

confidence: 99%

Effect of Corosolic Acid on the Hydrolysis of Disaccharides

Takagi

Miura

Ishibashi

et al. 2008

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

show abstract

“…Lagerstroemia speciosa L. (banaba) standardized to 1% corosolic acid (Glucosol™) at daily dosages of 32 and 48mg·day -1 for two weeks showed a significant reduction in blood glucose in T2DM patients (Judy et al, 2003). Acutely, corosolic acid also attenuated the postprandial rise in blood glucose post-OGTT, in a mixed sample of IGT, IFG, and healthy subjects (Fukushima et al, 2006).…”

Section: Banaba and Berberinementioning

confidence: 99%

Minimizing Postprandial Oxidative Stress in Type 2 Diabetes: The Role of Exercise and Selected Nutrients

McCarthy¹,

Farney²

2011

Role of the Adipocyte in Development of Type 2 Diabetes

View full text Add to dashboard Cite

“…Recently, it has been reported that various active ingredients isolated from L. speciosa leaves shows their hypoglycemic properties through increase the rate of glucose uptake or inducing glucose transport like insulin and decrease the isoproterenol-induced glycerol release (Liu et al, 2001;Hattori et al, 2003;Klein et al, 2007). Although critical evaluation for clinical use has not been reported, a recent study showed that standard extract from L. speciosa leaves exerts its hypoglycemic effect on type II diabetes (Judy et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic activity of Lagerstroemia speciosa L. extract on streptozotocin-induced diabetic rat: Underlying mechanism of action

Saha

Bhuiyan

Mazumder

et al. 2009

Bangladesh J Pharmacol

View full text Add to dashboard Cite

The hypoglycemic effect of Lagerstroemia speciosa L. leaves hot water extract on chemically induced diabetes in rat was investigated. Experimental result showed that, streptozotocin significantly (p<0.001) elevated the normal blood sugar level whereas treatment with hot water extract depressed the streptozotocin-induced high blood sugar level about 43.2% as compare to diabetic controls. Treatment with hot water extract increased the activity of shunt enzyme glucose-6-phosphate dehydrogenase (33.8%) and glutathione level (31.3%) and depression of the activity of hepatic gluconeogenic enzymes glucose-6-phasphatase (31.6%) and fructose-1,6-bisphosphatase (27.4%). These studies thus strongly suggest that the hot water extract of L. speciosa leave attributed its prominent hypoglycemic activity on experimental diabetic rats through suppression of gluconeogenesis and stimulation of glucose oxidation using the pentose phosphate pathway.

show abstract

Antidiabetic activity of a standardized extract (Glucosol™) from Lagerstroemia speciosa leaves in Type II diabetics

Cited by 121 publications

References 5 publications

Effect of Corosolic Acid on the Hydrolysis of Disaccharides

Effect of Corosolic Acid on the Hydrolysis of Disaccharides

Minimizing Postprandial Oxidative Stress in Type 2 Diabetes: The Role of Exercise and Selected Nutrients

Hypoglycemic activity of Lagerstroemia speciosa L. extract on streptozotocin-induced diabetic rat: Underlying mechanism of action

Contact Info

Product

Resources

About