Antidepressants. Tetrabenazine-antagonizing activity in a series of 5H-dibenzo[cycloheptene-5-propylamines

El, Engelhardt; Me, Christy; Cd, Colton; Mb, Freedman; Cc, Boland; Lm, Halpern; Vg, Vernier; Ca, Stone

doi:10.1021/jm00308a031

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1974

2015

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Cited by 15 publications

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“…(CiSH29Cl2N302) C. , N. Miscellaneous Reactions. 2-Methyl-5,6-dihydro-4H-benzo- [3,4]cyclohepta[l,2-d]oxazol-5-one (9). Dropwise, 27 ml of 30%> H2O2 was added to a stirred (10°) solution of 33 (26.9 g, 0.136 mol) in HCOOH (54 ml) over 30 min.…”

Section: Discussionmentioning

confidence: 99%

Novel tricyclic systems. Oxazole, thiazole, and imidazole analogs of the amitriptyline type

Galantay¹,

Simpson²,

Corriveau³

et al. 1974

J. Med. Chem.

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Section: Discussionmentioning

confidence: 99%

Novel tricyclic systems. Oxazole, thiazole, and imidazole analogs of the amitriptyline type

Galantay¹,

Simpson²,

Corriveau³

et al. 1974

J. Med. Chem.

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“…The reaction product was isolated by flash chromatography. The maximum yield of compound IIIa (84%) was attained under catalysis with Sc(OTf) 3 ; an efficiency of two other catalysts, In(OTf) 3 and Cu(OTf) 2 , was quite similar: the product was prepared in 82 and 79% yield, respectively.…”

mentioning

confidence: 92%

“…Some antidepressants like protriptyline [3] and its structural analogs, nitrogen-containing compounds with dibenzosuberene fragment, are well known and are used as muscle relaxants and histamine antagonists. Thus, 2-(dibenzosuberen-5-yl)indane-1,3-dione inhibits some enzymes [4][5][6] and can be used as a starting compound for the synthesis of various derivatives due to the presence of 1,3dicarbonyl fragment, which possesses a great synthetic potential [7,8].…”

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confidence: 99%