Antidepressant use before and after initiation of diabetes mellitus treatment

Knol, Mirjam J.; Geerlings, Mirjam I.; Grobbee, Diederick E.; Egberts, Toine C. G.; Heerdink, Eibert R.

doi:10.1007/s00125-008-1249-8

Cited by 27 publications

(13 citation statements)

References 24 publications

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“…One study [ 34 ] reported two datasets for patients with prevalent and incident diabetes, leaving a total of 13 datasets for analysis. Three studies [ 35 , 36 , 37 ] used incident prescription of antidepressants as a proxy for depression diagnosis, five studies [ 34 , 38 , 39 , 40 , 41 ] used clinical diagnostic criteria, and three [ 42 , 43 , 44 ] relied on questionnaires. One study used both questionnaires and prescription of antidepressants [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

Risk of Depression and Suicidality among Diabetic Patients: A Systematic Review and Meta-Analysis

Elamoshy

Bird

Thorpe

et al. 2018

JCM

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The purpose of this study is to conduct a systematic review and meta-analysis to evaluate the risk of depression and suicidality among diabetic patients. Methods: Medline, PubMed, EMBASE, Cochrane library, and Psych INFO were searched for studies published from 2008 onwards. Meta-analysis was conducted to estimate the pooled effect size. Sources of heterogeneity were investigated by subgroup analysis and meta-regression. Results: In total, 5750 articles were identified and of those, 17 studies on suicidality and 36 on depression were included in this study. Our analysis suggests a positive relationship between diabetes and depression (cohort studies odds ratio (OR) 1.49, 95% confidence interval (CI): 1.36–1.64 and cross-sectional studies OR 2.04, 95% CI, 1.73–2.42). Pooled OR values for suicidal ideation, attempted suicide, and completed suicide were 1.89 (95% CI: 1.36–2.63), 1.45 (95% CI: 1.07–1.96), and 1.85 (95% CI: 0.97–3.52), respectively. All findings were statistically significant except for completed suicide. Conclusions: The increased risk of depression and suicidality in diabetic patients highlights the importance of integrating the evaluation and treatment of depression with diabetes management in primary healthcare settings. Further research in this area is needed.

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Section: Resultsmentioning

confidence: 99%

Risk of Depression and Suicidality among Diabetic Patients: A Systematic Review and Meta-Analysis

Elamoshy

Bird

Thorpe

et al. 2018

JCM

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“…Antidepressant use was examined in 49,593 people with diabetes and a random sample of 154,441 people without diabetes included in a pharmacy database in the Netherlands (17). Antidepressant use was only increased 2 months before and 3 months after initiation of diabetes treatment, with the marked increase in the incidence of antidepressant use in the month after initiation of diabetes treatment, with incidence rate ratio of 2.4 (95% CI 2.0–3.0).…”

Section: Resultsmentioning

confidence: 99%

Antidepressant Medication as a Risk Factor for Type 2 Diabetes and Impaired Glucose Regulation

2013

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OBJECTIVEAntidepressant use has risen sharply over recent years. Recent concerns that antidepressants may adversely affect glucose metabolism require investigation. Our aim was to assess the risk of type 2 diabetes associated with antidepressants through a systematic review.RESEARCH DESIGN AND METHODSData sources were MEDLINE, Embase, PsycINFO, The Cochrane Library, Web of Science, meeting abstracts of the European Association for the Study of Diabetes, American Diabetes Association, and Diabetes UK, Current Controlled Trials, ClinicalTrials.gov, U.K. Clinical Research Network, scrutiny of bibliographies of retrieved articles, and contact with relevant experts. Relevant studies of antidepressant effects were included. Key outcomes were diabetes incidence and change in blood glucose (fasting and random).RESULTSThree systemic reviews and 22 studies met the inclusion criteria. Research designs included 1 case series and 21 observational studies comprising 4 cross-sectional, 5 case-control, and 12 cohort studies. There was evidence that antidepressant use is associated with type 2 diabetes. Causality is not established, but rather, the picture is confused, with some antidepressants linked to worsening glucose control, particularly with higher doses and longer duration, others linked with improved control, and yet more with mixed results. The more recent, larger studies, however, suggest a modest effect. Study quality was variable.CONCLUSIONSAlthough evidence exists that antidepressant use may be an independent risk factor for type 2 diabetes, long-term prospective studies of the effects of individual antidepressants rather than class effects are required. Heightened alertness to potential risks is necessary until these are complete.

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“…We did not account for antidepressant medication use in these analyses. Because of concerns regarding confounding by indication (Knol et al, 2009), methods beyond regression models that explicitly account for selection effects (e.g., propensity score techniques) are necessary to assess whether antidepressants are associated with type 2 diabetes risk above and beyond depressive symptomology (Glynn et al, 2006; Rubin, 2004). Finally, because of the modest ICC (0.013) we had limited statistical power to identify the influence of factors at this level.…”

Section: Discussionmentioning

confidence: 99%

Depression, neighborhood deprivation and risk of type 2 diabetes

Mezuk

Chaikiat

et al. 2013

Health & Place

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Neighborhood characteristics have been associated with both depression and diabetes, but to date little attention has been paid to whether the association between depression and diabetes varies across different types of neighborhoods. This prospective study examined the relationship between depression, neighborhood deprivation, and risk of type 2 diabetes among 336,340 adults from a national-representative sample of primary care centers in Sweden (2001–2007). Multi-level logistic regression models were used to assess associations between depression and risk of type 2 diabetes across affluent and deprived neighborhoods. After accounting for demographic, individual-level socioeconomic, and health characteristics, depression was significantly associated with risk of diabetes (odds ratio (OR): 1.10, 95% confidence interval (CI): 1.06–1.14), as was neighborhood deprivation (OR for high vs. low deprivation: 1.66, 95% CI: 1.22–1.34). The interaction term between depression and neighborhood deprivation was non-significant, indicating that the relationship between depression and diabetes risk is similar across levels of neighborhood socioeconomic deprivation.

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Antidepressant use before and after initiation of diabetes mellitus treatment

Cited by 27 publications

References 24 publications

Risk of Depression and Suicidality among Diabetic Patients: A Systematic Review and Meta-Analysis

Risk of Depression and Suicidality among Diabetic Patients: A Systematic Review and Meta-Analysis

Antidepressant Medication as a Risk Factor for Type 2 Diabetes and Impaired Glucose Regulation

Depression, neighborhood deprivation and risk of type 2 diabetes

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