Risk of Depression and Suicidality among Diabetic Patients: A Systematic Review and Meta-Analysis

Elamoshy, Rasha; Bird, Yelena; Thorpe, Lilian; Moraros, John

doi:10.3390/jcm7110445

Cited by 31 publications

(23 citation statements)

References 87 publications

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“…People with diabetes were more often suicidal than people without diabetes. The pooled OR values for suicidal ideation, attempted suicide and completed suicide were 1.89 (95% CI 1.36–2.63), 1.45 (95% CI 1.07–1.96) and 1.85 (95% CI 0.97–3.52), respectively .…”

Section: What We Now Know After 25 Years Of Research Into Diabetes Anmentioning

confidence: 97%

“…Five studies focused on suicide attempts or self‐harm. Nine cross‐sectional studies examined suicidal ideation . People with diabetes were more often suicidal than people without diabetes.…”

Section: What We Now Know After 25 Years Of Research Into Diabetes Anmentioning

confidence: 99%

“…The mechanisms that explain why depression is associated with poor outcomes in diabetes are unclear and understudied in individuals with type 1 diabetes. Current hypotheses distinguish mechanisms at a behavioural level, such as the burden of disease hypothesis and adverse lifestyle behaviour, and at a biological level, involving the effects of hyperglycaemia, hypothalamic–pituitary–adrenal (HPA) axis deregulation, low‐grade inflammation and microvascular dysfunction . From a behavioural perspective, depression can impair several different self‐care behaviours; a systematic review of 47 studies concluded that depression in people with diabetes was linked with less optimal self‐care behaviours, lower diet quality, less optimal medication use and less frequent glucose monitoring, and lower appointment keeping .…”

Section: What We Now Know After 25 Years Of Research Into Diabetes Anmentioning

confidence: 99%

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How 25 years of psychosocial research has contributed to a better understanding of the links between depression and diabetes

et al. 2020

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This narrative review of the literature provides a summary and discussion of 25 years of research into the complex links between depression and diabetes. Systematic reviews have shown that depression occurs more frequently in people with type 1 or type 2 diabetes compared with people without diabetes. Currently, it remains unclear whether depression is also more common in people with impaired glucose metabolism or undiagnosed type 2 diabetes compared with people without diabetes. More prospective epidemiological research into the course of depression and an exploration of mechanisms in individuals with diabetes are needed. Depression in diabetes is associated with less optimal self‐care behaviours, suboptimal glycaemic control, impaired quality of life, incident micro‐ and macrovascular diseases, and elevated mortality rates. Randomized controlled trails concluded that depression in diabetes can be treated with antidepressant medication, cognitive–behavioural therapy (individual, group‐based or web‐based), mindfulness‐based cognitive therapy and stepped care. Although big strides forward have been made in the past 25 years, scientific evidence about depression in diabetes remains incomplete. Future studies should investigate mechanisms that link both conditions and test new diabetes‐specific web‐ or app‐based interventions for depression in diabetes. It is important to determine whether treatment or prevention of depression prevents future diabetes complications and lowers mortality rates.

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Section: What We Now Know After 25 Years Of Research Into Diabetes Anmentioning

confidence: 97%

Section: What We Now Know After 25 Years Of Research Into Diabetes Anmentioning

confidence: 99%

Section: What We Now Know After 25 Years Of Research Into Diabetes Anmentioning

confidence: 99%

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How 25 years of psychosocial research has contributed to a better understanding of the links between depression and diabetes

et al. 2020

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“…DM is psychologically demanding given the large and chronic burden placed on patients for the self-management of their disease. Patients have to face some challenges such as adherence to drug treatment, modifications of lifestyle, concerns for complications and disabilities, and psychosocial difficulties at personal and interpersonal levels, leading to depression of DM patients [4]. Moreover, DM patients suffered from depression is often accompanied by cognitive dysfunction [5].…”

Section: Introductionmentioning

confidence: 99%

Gastrodin Alleviates Cognitive Dysfunction and Depressive-Like Behaviors by Inhibiting ER Stress and NLRP3 Inflammasome Activation in db/db Mice

Ye¹,

Meng

Wang

et al. 2018

IJMS

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Patients with diabetes mellitus (DM) suffer more risks from diabetic encephalopathy such as cognitive dysfunction and depressive-like behaviors. Numerous studies show that ER (endoplasmic reticulum) stress and inflammation play important roles in the development of diabetic encephalopathy. Gastrodin (Gas), one major component of Gastrodia elata, is traditionally used in central nervous system disorders and is believed to possess anti-inflammatory, anti-apoptotic, and other neuroprotective effects. This present study aims to explore the protective effects of Gas on diabetic encephalopathy. Gas was administrated daily (70 and 140 mg/Kg) for 12 weeks. Meanwhile, the fasting blood glucose and body weight of db/db mice were measured every two weeks. After Gas treatment, the Morris water maze (MWM) test and novel object recognition (NOR) test were performed to assess the learning and memory functions of db/db mice, and the forced swim test was performed to evaluate depressive-like behaviors of db/db mice. Additionally, the expression of ER stress and Nucleotide binding and oligomerization domain-like (Nod) receptor family pyrin domain-containing 3 (NLRP3) inflammasome related proteins were evaluated by using Western blot. Our study suggested that Gas attenuated blood glucose levels and dyslipidemia of db/db mice. It has been shown that Gas could improve learning and memory function and depressive-like behaviors of db/db mice. Moreover, Gas inhibited ER stress and NLRP3 inflammasome activation in the hippocampus. Taken together, this study demonstrates that Gas attenuates the diabetic encephalopathy by inhibiting ER stress and NLRP3 inflammasome activation.

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“…Diabetes mellitus is highly associated with depression. 72 If untreated, it leads to cardiovascular complications, themselves associated with mood disorders or dementia. Obesity, the major risk factor for cardiovascular disorders, and a source of stigmatization among young people, shows a reciprocal link with depression.…”

Section: Outlook and Conclusionmentioning

confidence: 99%

Treating psychiatric symptoms and disorders with non-psychotropic medications

Hede¹,

Devillé²

2019

Dialogues in Clinical Neuroscience

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A few drugs prescribed in internal medicine, ie, non-psychotropic drugs, can be used to treat certain neuropsychiatric disorders. For most of these situations, the level of evidence remains low. But when sufficient data becomes available, these molecules are then included in official guidelines for the treatment of neuropsychiatric disorders. In this article we review interesting drugs which may be relevant from an evidence-based medicine point of view, and could become part of psychiatric practice in the future.

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Risk of Depression and Suicidality among Diabetic Patients: A Systematic Review and Meta-Analysis

Cited by 31 publications

References 87 publications

How 25 years of psychosocial research has contributed to a better understanding of the links between depression and diabetes

How 25 years of psychosocial research has contributed to a better understanding of the links between depression and diabetes

Gastrodin Alleviates Cognitive Dysfunction and Depressive-Like Behaviors by Inhibiting ER Stress and NLRP3 Inflammasome Activation in db/db Mice

Treating psychiatric symptoms and disorders with non-psychotropic medications

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