Antidepressant-type effect of the NK3 tachykinin receptor agonist aminosenktide in mouse lines differing in endogenous opioid system activity

Panocka, Izabela; Massi, Maurizio; Łapo, Iwona B.; Swiderski, T; Kowalczyk, Marek; Sadowski, Bogdan

doi:10.1016/s0196-9781(01)00438-7

Cited by 37 publications

(19 citation statements)

References 52 publications

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“…The results of the present study demonstrating an antidepressant-like effect in the forced swim test by SR 142801 are in apparent conflict with another report showing that the NK 3 receptor agonist, aminosenktide, had similar effects in the forced swim test in some mice (Panocka et al, 2001). It is difficult to account for this difference because the mice were selected over 43 generations for differences in opioid-mediated analgesia.…”

Section: Discussioncontrasting

confidence: 99%

Antidepressant-like effects of neurokinin receptor antagonists in the forced swim test in the rat

Dableh

Yashpal

Rochford

et al. 2005

European Journal of Pharmacology

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Although a wide assortment of agents is currently available for the treatment of depression, this disorder remains poorly managed in a large proportion of patients. Traditional antidepressant treatments target the biogenic amine systems. However, a growing body of evidence is implicating the involvement of neuropeptides in depression, especially the neurokinin substance P. This study evaluated the effects of selective antagonists of the tachykinin NK 1 , NK 2 , and NK 3 receptors in the forced swim test, a commonly used screen for antidepressants. Rats were given CP-96,345 (2S,propyl)-4-phenylpiperidin-4-yl)-N-methylacetamide, antagonists of the NK 1 , NK 2 , and NK 3 receptors, respectively, at doses of 2.5, 5, and 10 mg/kg, intraperitoneally (i.p.). The time of immobility during the forced swim test was used as an indicator of antidepressant activity of the antagonists. All antagonists decreased immobility times. CP-96,345 and SR 142801 showed doserelated effects; SR 48968 had its maximum effect at 2.5 mg/kg. The magnitude of the effects of the neurokinin receptor antagonists was approximately the same as that of amitriptyline and desipramine, two traditional antidepressants, both given at 10 mg/kg, i.p. This study provides comparative data on the relative effectiveness of NK 1 , NK 2 , and NK 3 receptor antagonists in this screen for antidepressant drug activity.

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Section: Discussioncontrasting

confidence: 99%

Antidepressant-like effects of neurokinin receptor antagonists in the forced swim test in the rat

Dableh

Yashpal

Rochford

et al. 2005

European Journal of Pharmacology

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“…Island populations of deer mice, in comparison with mainland conspecifics, display higher opioid-mediated analgesia and lower level of locomotor activity in response to stressors [16]. In agreement with these observations, HA mice, in contrast to LA mice, remain immobile at the beginning of the open field test [2], and at certain swim parameters adopt a passive behaviour, possibly mediated by endogenous opioids [27].…”

Section: Interaction Of Analgesic and Thermoregulatory Mechanisms Dursupporting

confidence: 69%

Analgesia induced by swim stress: interaction between analgesic and thermoregulatory mechanisms

Łapo

Konarzewski

Sadowski

2003

Pflugers Arch - Eur J Physiol

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Exposure of an animal to stressful stimuli, perceived by the animal as a threatening, emergency condition, elicits a transient decrease of pain sensitivity, which often affects thermoregulatory mechanisms in the threatened organism. We studied the interaction between emergency and thermoregulatory components of swim stress in developing swim stress-induced analgesia (SSIA). The subjects were mice selectively bred for high analgesia (HA) induced by swimming in 20 degrees C water, and displaying profound swim hypothermia. The mice were acclimated to one of the following conditions: (1) ambient cold (5 degrees C, mimicking the thermal component of swim stress); (2) daily 3-min swimming at 32 degrees C (mimicking the emergency, emotional in nature, component of swim stress), or (3) daily swimming at 20 degrees C (a combination of both emergency and thermal component of swim stress). Following each of the procedures the analgesia induced by swimming in 20 degrees C water and by acute exposure to -2.5 degrees C in helium/oxygen (Helox) atmosphere was measured. Analgesia was also assessed in a group of naive mice immersed in 20 degrees C shallow water with the purpose of eliminating the emergency condition, but assuring the animal's contact with the cold water environment. Cold acclimation markedly attenuated Helox-induced analgesia (HIA) without affecting SSIA, whereas repeated swims attenuated SSIA without affecting HIA. The results suggest that hypothermia is the only stimulus eliciting HIA, while the emergency condition of swimming is essential for inducing SSIA. The significantly lower magnitude of SSIA in mice acclimated to repeated swims in 20 degrees C than in 32 degrees C water suggests that SSIA develops due to an interaction between the emergency and hypothermic components of swim stress. This is further supported by a greater hypothermia and greater analgesia in freely swimming than in immersed naive mice.

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“…In these areas, NK-3 receptors play a role in pathological inflammatory processes implicated in diseases such as asthma, inflammatory bowel syndrome and cystitis (Canning, 2006; Patacchini and Maggi, 2001). In the central nervous system, their role in modulating dopamine transmission makes them potential targets in treatment of neuropsychiatric illnesses including schizophrenia and various affective disorders, and also Parkinson’s disease (Panocka et al, 2001; Ribeiro and De Lima, 1998; Spooren et al, 2005). Findings from the present study lead us to propose further inquiry into possible consequences of chronic use of agents that function as NK-3 receptor antagonists.…”

Section: Discussionmentioning

confidence: 99%

Blockade of neurokinin-3 receptors modulates dopamine-mediated behavioral hyperactivity

Nwaneshiudu

Unterwald

2009

Neuropharmacology

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Acute activation or blockade of neurokinin-3 (NK-3) receptors has been shown to alter dopamine-mediated function and behaviors, however long-term effects of NK-3 receptor blockade remain largely unknown. The present study investigated whether acute and repeated administration of the NK-3 receptor antagonist SB 222200 altered hyperactivity induced by cocaine, and examined its effects on dopamine D1 receptor density in the striatum. Adult male CD-1 mice received either vehicle or SB222200 (2.5 or 5 mg/kg, s.c.) 30 mins before a cocaine injection (20 mg/kg, i.p.) and behavioral responses were recorded. Mice that were administered SB 222200 had an attenuated stereotypic response to cocaine compared to vehicle treated mice. Mice were also injected once daily with either vehicle or SB 222200 (5 mg/kg, s.c.) for 5 days, and after a 7-day drug-free period they were challenged with either saline, cocaine or the dopamine D1 receptor agonist SKF 82958 (0.125 or 0.25 mg/kg, i.p.). Mice injected with SB 222200 had significantly enhanced hyperactivity when challenged with cocaine or a low dose of SKF 82958 (0.125 mg/kg, i.p.) compared to control mice. Brains of mice administered vehicle or SB 222200 for 5 days were harvested after a 7-day drug-free period for dopamine D1 receptor quantification by radioligand binding. [3H] SCH 23390 homogenate binding studies showed a 19.7% increase in dopamine D1 receptor density in the striatum of SB 222200 treated mice. These data suggest that repeated blockade of NK-3 receptors enhances subsequent dopamine-mediated behaviors possibly resulting from dopamine D1 receptor up-regulation in the striatum.

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Antidepressant-type effect of the NK3 tachykinin receptor agonist aminosenktide in mouse lines differing in endogenous opioid system activity

Cited by 37 publications

References 52 publications

Antidepressant-like effects of neurokinin receptor antagonists in the forced swim test in the rat

Antidepressant-like effects of neurokinin receptor antagonists in the forced swim test in the rat

Analgesia induced by swim stress: interaction between analgesic and thermoregulatory mechanisms

Blockade of neurokinin-3 receptors modulates dopamine-mediated behavioral hyperactivity

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