Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression

Fales, Christina L.; Deanna, M; Rundle, Melissa M.; Mintun, Mark A.; Mathews, Jose; Snyder, Abraham Z.; Sheline, Yvette I.

doi:10.1016/j.jad.2008.04.027

Cited by 234 publications

(155 citation statements)

References 19 publications

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“…15,17,27,[37][38][39][40][41][42][43][44][45][46] Our results are in agreement with those and similar findings, 6,14,47 indicating that a stronger prefrontal-parietal BOLD signal during the eliciting of emotion is a neural correlate of the effect of the drug on mood regulation. This effect appears to be independent of the clinical (therapeutic) action, because it also occurs in healthy individuals.…”

Section: Discussionsupporting

confidence: 90%

Estudo de ressonância magnética funcional das mudanças da atividade cerebral durante recordações afetivas autobiográficas decorrentes da administração prolongada de clomipramina a sujeitos saudáveis

Cerqueira¹

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À Profa. Dr. Cláudia da Costa Leite, na alocação do material e pessoal necessário para aquisição dos exames; bem como sua disposição para colaboração e críticas na redação dos artigos científicos.Ao amigo Fábio Moreira pelo auxílio na revisão de linguagem dessa tese.À "colega" e amiga biomédica, Maria Ângela Barreiros, pela contribuição na aquisição de dados e na análise de imagens; e companheira nas "baladas" do protocolo "Sol da Meia Noite". Ao Dr. Fábio Barros, pela sua atenção, dedicação e importância no início do estabelecimento da técnica de Ressonância Magnética funcional em nosso meio, e pelas valiosas discussões e orientações nos primórdios da concepção desse estudo. iv Ao grande colega e amigo Fábio de Souza Duran, pela sempre pronta disposição em ajudar, seja na organização de nossos arquivos, com o sistema linux, seja na orientação e produção de figuras para nossos textos e artigos; bem como nos momentos de descontração durante nossos almoços e happy hours nas redondezas.À colega e amiga Doutora Maurien Tebinka Senhorini pela amizade, discussões e desabafos, durante nossos protocolos, análises e produção de artigos, que reverteram para mim conhecimento e experiência para os momentos que se seguiram; bem como, pelo companheirismo durante nossos protocolos e happy hours.

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Section: Discussionsupporting

confidence: 90%

Estudo de ressonância magnética funcional das mudanças da atividade cerebral durante recordações afetivas autobiográficas decorrentes da administração prolongada de clomipramina a sujeitos saudáveis

Cerqueira¹

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“…Although the results have not always been consistent due to differences in tasks or patients' clinical profiles, fMRI studies 56,57 have also revealed a hypofunctioning dorsal cognitive control system and a hyperfunctioning emotional system. Furthermore, casecontrol studies in depressed patients without medication 58 have found elevated activation in response to negative stimuli in the amygdala, as well as either decreased or increased activation in the dorsolateral-prefrontal cortex (dlPFC) and dorsal anterior cingulate cortex, depending on task load. 59 Pilot studies of patients on antidepressants have found a reversal of this pattern as a result of mood improvement.…”

Section: Potential Neural Mechanisms Underlying the Effectiveness Of mentioning

confidence: 99%

“…59 Pilot studies of patients on antidepressants have found a reversal of this pattern as a result of mood improvement. 53,58,60 Whereas antidepressants have been hypothesized to target the amygdala and other limbic regions directly and affect a bottom-up pathway, cognitive behavioral therapy (CBT) has been proposed to operate on the dorsal cognitive control system and to affect a top-down control pathway. 52,55,61 Antidepressants appear to increase the activity of the dlPFC, 60,62 whereas CBT may decrease dlPFC activity and increase activity in the hippocampus and the dorsal cingulate.…”

Section: Potential Neural Mechanisms Underlying the Effectiveness Of mentioning

confidence: 99%

Delivering Happiness: Translating Positive Psychology Intervention Research for Treating Major and Minor Depressive Disorders

Layous

Chancellor

Lyubomirsky

et al. 2011

The Journal of Alternative and Complementary Medicine

110

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Despite the availability of many treatment options, depressive disorders remain a global public health problem. Even in affluent nations, 70% of reported cases either do not receive the recommended level of treatment or do not get treated at all, and this percentage does not reflect cases of depression that go unreported due to lack of access to health care, stigma, or other reasons. In developing countries, the World Health Organization estimates that < 10% receive proper depression care due to poverty, stigma, and lack of governmental mental health resources and providers. Current treatments do not work for everyone, and even people who achieve remission face a high risk of recurrence and residual disability. The development of low-cost effective interventions that can serve either as initial therapy for mild symptoms or as adjunctive therapy for partial responders to medication is an immense unmet need. Positive activity interventions (PAIs) teach individuals ways to increase their positive thinking, positive affect, and positive behaviors. The majority of such interventions, which have obtained medium-size effect sizes, have been conducted with nondepressed individuals, but two randomized controlled studies in patients with mild clinical depression have reported promising initial findings. In this article, the authors review the relevant literature on the effectiveness of various types of PAIs, draw on social psychology, affective neuroscience and psychophamacology research to propose neural models for how PAIs might relieve depression, and discuss the steps needed to translate the potential promise of PAIs as clinical treatments for individuals with major and minor depressive disorders.

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“…The attentional set-shifting test (AST) was developed to measure cognitive flexibility in rats, including extra-dimensional (ED) cognitive set-shifting, which depends critically on the functional integrity of the medial prefrontal cortex (mPFC) (Birrell and Brown, 2000). This region has been shown to be hypoactive in depressed patients and individuals exposed to chronic psychosocial stress (Stuss et al, 2000;Siegle et al, 2007;Fales et al, 2009;Liston et al, 2009). In previous studies, we found that chronic unpredictable stress (CUS) compromised the performance of rats on the ED stage of the AST (Bondi et al, 2008(Bondi et al, , 2010.…”

Section: Introductionmentioning

confidence: 99%

Too Much of a Good Thing: Blocking Noradrenergic Facilitation in Medial Prefrontal Cortex Prevents the Detrimental Effects of Chronic Stress on Cognition

Jett

Morilak

2012

Neuropsychopharmacol

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Cognitive impairments associated with dysfunction of the medial prefrontal cortex (mPFC) are prominent in stress-related psychiatric disorders. We have shown that enhancing noradrenergic tone acutely in the rat mPFC facilitated extra-dimensional (ED) set-shifting on the attentional set-shifting test (AST), whereas chronic unpredictable stress (CUS) impaired ED. In this study, we tested the hypothesis that the acute facilitatory effect of norepinephrine (NE) in mPFC becomes detrimental when activated repeatedly during CUS. Using microdialysis, we showed that the release of NE evoked in mPFC by acute stress was unchanged at the end of CUS treatment. Thus, to then determine if repeated elicitation of this NE activity in mPFC during CUS may have contributed to the ED deficit, we infused a cocktail of a 1 -, b 1 -, and b 2 -adrenergic receptor antagonists into the mPFC prior to each CUS session, then tested animals drug free on the AST. Antagonist treatment prevented the CUS-induced ED deficit, suggesting that NE signaling during CUS compromised mPFC function. We confirmed that this was not attributable to sensitization of adrenergic receptor function following chronic antagonist treatment, by administering an additional microinjection into the mPFC immediately prior to ED testing. Acute antagonist treatment did not reverse the beneficial effects of chronic drug treatment during CUS, nor have any effect on baseline ED performance in chronic vehicle controls. Thus, we conclude that blockade of noradrenergic receptors in mPFC protected against the detrimental cognitive effects of CUS, and that repeated elicitation of noradrenergic facilitatory activity is one mechanism by which chronic stress may promote mPFC cognitive dysfunction.

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Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression

Abstract: The sample was fairly homogeneous and this may limit generalizability.

Cited by 234 publications

References 19 publications

Estudo de ressonância magnética funcional das mudanças da atividade cerebral durante recordações afetivas autobiográficas decorrentes da administração prolongada de clomipramina a sujeitos saudáveis

Estudo de ressonância magnética funcional das mudanças da atividade cerebral durante recordações afetivas autobiográficas decorrentes da administração prolongada de clomipramina a sujeitos saudáveis

Delivering Happiness: Translating Positive Psychology Intervention Research for Treating Major and Minor Depressive Disorders

Too Much of a Good Thing: Blocking Noradrenergic Facilitation in Medial Prefrontal Cortex Prevents the Detrimental Effects of Chronic Stress on Cognition

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