Antidepressant-related adverse effects impacting treatment compliance: Results of a patient survey

Ashton, Adam Keller; Jamerson, Brenda D.; Weinstein, Wendy L.; Wagoner, Christine

doi:10.1016/j.curtheres.2005.04.006

Cited by 116 publications

(79 citation statements)

References 10 publications

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“…Cross sectional population survey also reveal that sexual problems among men were associated with anxiety and medical problems, whereas for women sexual dysfunction was associated with marital difficulties. Studies evaluating the marital relationship have shown that marital satisfaction was significantly associated with sexual desire [45]. Other researchers consider marital distress as a causal determinant and as an outcome of low sexual desire; low marital satisfaction can reduce motivation for sexual intimacy and perhaps even promote sexual withholding, and lack of sexual desire over time can lead to frustration and dissatisfaction.…”

Section: Impact Of Sexual Dysfunctionmentioning

confidence: 99%

“…One of the important consequences of sexual dysfunction in people taking antidepressants is poor treatment acceptance and compliance [45]. Studies have shown that sexual dysfunction is the 2nd most frequent side effect rated as "extremely difficult to live with" after weight gain and 3rd most frequently reported side effect as a cause of noncompliance [47].…”

Section: Impact Of Sexual Dysfunction On Compliancementioning

confidence: 99%

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Sexual Dysfunctions in Depression

J¹,

Rao²,

Chandran³

et al. 2017

Clin Depress

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Sexual dysfunction is one of the common symptoms seen in depression. Presentations include decreased libido, erectile dysfunction, arousal difficulties and orgasm related dysfunctions. The probable causes of sexual dysfunction in such patients are complex and biological, psychological as well as psychosocial factors are likely to play an important role. Sexual dysfunction could also occur as an adverse effect of anti-depressants although it is difficult to establish whether the dysfunction is due to the illness or the medication. Awareness among professionals about sexual dysfunction is essential as it can have a profound impact in terms of relationship conflict, marital satisfaction, quality of life and compliance with treatment in patients with depression.

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Section: Impact Of Sexual Dysfunctionmentioning

confidence: 99%

Section: Impact Of Sexual Dysfunction On Compliancementioning

confidence: 99%

Sexual Dysfunctions in Depression

J¹,

Rao²,

Chandran³

et al. 2017

Clin Depress

View full text Add to dashboard Cite

show abstract

“…While SSRIs and TCAs are similarly effective [33], SSRIs are prescribed more often because of their favourable side-effect profile [34]. Rates of antidepressant treatment discontinuation can reach up to 60 per cent, and adverse effects are the most common reason for nonadherence and drug discontinuation [35]. Fifteen to twenty-seven per cent of patients discontinue medication use owing to perceived side effects [36].…”

Section: Nocebo Effects In Antidepressant Trialsmentioning

confidence: 99%

Lessons learned from placebo groups in antidepressant trials

Shedden-Mora

Nestoriuc

Rief

2011

Phil. Trans. R. Soc. B

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This comprehensive review provides an overview about placebo and nocebo phenomena in antidepressant trials. Improvements in the placebo groups may partly be explained through methodological issues such as natural course of depression and regression to the mean, but also fundamentally reflect investigators' and participants' expectations. A meta-analysis by our group of 96 randomized placebo-controlled trials showed large placebo responses to antidepressant medication. Moderator analyses revealed substantially larger placebo responses in observer ratings compared with self-report. Effect sizes in observer ratings showed strong increase with publication year while this effect was not found for patients' self-ratings. This reflects the strong influence of investigators' expectations. The analysis of 'nocebo effects', e.g. adverse effects in placebo groups of antidepressant trials also confirms the impact of expectations: nocebo symptoms reflected the typical side-effect patterns expected in the drug group, with higher symptoms rates in the placebo groups of tricyclic antidepressant trials compared with placebo groups of trials testing selective serotonin reuptake inhibitors. While the placebo response seems to be similar for women and men, gender differences were found for nocebo rates. In the conclusion, we discuss potential implications for clinical trial designs and argue for interventions aimed at optimizing positive expectations of treatment benefit while minimizing the impact of adverse effects.

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“…The most common reasons were forgetfulness (43 per cent), sexual dysfunction (40 per cent), weight gain (27 per cent) and daytime drowsiness (21 per cent). 23 Side-effects such as nausea, headache, drowsiness and increased anxiety are common reasons why 43 per cent to 62 per cent of patients stop taking both old and the newer antidepressants. 9,24 In patients in maintenance phase treatment with antidepressants, compliance was lowest when perceived harm exceeded perceived need and highest when perceived need exceeded concerns about taking the medication.…”

Section: Why Do Patients Not Take Their Antidepressants As Prescribed?mentioning

confidence: 99%

Medicine taking behaviour in depression – part 1

Feetam¹

2009

Prog Neurol Psychiatry

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In this,the first of two articles,poor adherence with antidepressant treatment and the effect on outcome are explored.The factors important in the selection of an antidepressant are also considered. In the second article, treatment variables that may affect adherence will be examined alongside various interventions that have been proposed to improve medicine taking behaviour in patients with depression. Copyright © 2009 Wiley Interface Ltd

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Antidepressant-related adverse effects impacting treatment compliance: Results of a patient survey

Cited by 116 publications

References 10 publications

Sexual Dysfunctions in Depression

Sexual Dysfunctions in Depression

Lessons learned from placebo groups in antidepressant trials

Medicine taking behaviour in depression – part 1

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