Antidepressant prescribing in five European countries: application of common definitions to assess the prevalence, clinical observations, and methodological implications

Abbing‐Karahagopian, Victoria; Huerta, Consuelo; Souverein, Patrick C.; Abajo, Francisco de; Leufkens, Hubert G. M.; Slattery, Jim; Álvarez, Yolanda; Gil, Miguel; Oliva, Belén; Hesse, Ulrik; Requena, Gema; Vries, Frank de; Rottenkolber, Marietta; Schmiedl, Sven; Reynolds, Robert F.; Schlienger, Raymond G.; Groot, Mark de; Klungel, Olaf H.; Staa, Tjeerd van; Dijk, Liset van; Egberts, Toine C. G.; Gardarsdóttir, Helga; Bruin, Marie L. De

doi:10.1007/s00228-014-1676-z

Cited by 137 publications

(139 citation statements)

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“…This would enhance rational prescribing and affordability. In contrast to the findings of this study, SSRIs were the most frequently prescribed drugs in studies carried out in Asia, Europe, North America and India [3,14,15,21,[31][32][33][34] with decreased use of TCAs. Factors such as differences in culture, practice, promotional activity [32,35,36] and national income [37] contribute to these regional differences.…”

Section: Discussioncontrasting

confidence: 99%

Drug utilization patterns of antidepressants in Federal Neuro-Psychiatric Hospital Lagos, Nigeria

Kehinde

Anyika

Abah

2017

JHA

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Backgroud: The paucity of information on prescribing patterns and use of antidepressants in accordance with practice guidelines necessitated this study in Nigeria. Objective: To assess the prescribing patterns of antidepressants, average cost of prescriptions and the index of rational drug prescribing (IRDP) in a Nigerian tertiary care hospital. Methods: A retrospective study which involved the assessment of 683 prescriptions and case records of patients who received antidepressants from 1 st January 2013 to 31 st December 2014 was conducted. Information on diagnosis, patients' demographics, prescribing patterns and cost of medications was obtained therefrom. Compliance to the World Health Organization (WHO) prescribing indicators and Nigerian Standard Treatment Guidelines (STG) was assessed. The IRDP for antdepressants was determined using a validated mathematical model. The statistical analysis was performed using SPSS version 20. Results: Tricyclic antidepressants (TCAs) were the most commonly prescribed drug group (61.3%), followed by selective serotonin re-uptake inhibitors (SSRIs) with a total of 38.7%. On the average, three drugs were prescribed per prescription, while 60.3% and 38.3% of the drugs were prescribed from National Essential Medicine List (NEML) and STG respectively. The IRDP was 3.96 over 5 points. The average cost of drugs per prescription was 4.2 USD. The cost of drugs in the prescriptions written according to STG was lower compared to that in prescriptions not compliant with the STG (p < .001).Conclusions: TCAs are the most commonly prescribed antidepressants due to their affordability. The generic prescribing, medicines prescribed from the NEML and in compliance with the STG were less than the WHO standard. The rational drug use is suboptimal. Better prescribing habits, affordability and use of newer antidepressants should be encouraged by the hospital management.

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Section: Discussioncontrasting

confidence: 99%

Drug utilization patterns of antidepressants in Federal Neuro-Psychiatric Hospital Lagos, Nigeria

Kehinde

Anyika

Abah

2017

JHA

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“…Use of antidepressants in particular decreased in 2012, in contrast to the results obtained by various researchers from several countries who reported a significant increase in prescription of psychotropic drugs during the last decade [9,20,21,22,23]. However, use of anxiolytics increased to 24.3%, consistent with the results obtained in an ecological study based on Spanish pharmacy dispensing data [24] and with those of Tsimtsiou et al [12], who determined predictors of prescription of anxiolytics and hypnotics by general practitioners in England based on data from the UK Quality and Outcomes Framework.…”

Section: Discussionmentioning

confidence: 78%

Time Trend in Psychotropic Medication Use in Spain: A Nationwide Population-Based Study

Carrasco‐Garrido

Hernández-Barrera

Trujillo

et al. 2016

IJERPH

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Background: We performed an epidemiologic study to analyze nationwide time trends in adult psychotropic drug use over a period from 2006 to 2012, and to identify those factors associated with the likelihood of consumption of these drugs during the study period; Methods: Cross-sectional study on psychotropic medication in the Spanish adult population. We used secondary individualized data drawn from the 2006 and 2012 Spanish National Health Surveys (SNHS). The dependent variable was the use of psychotropic drugs in the previous two weeks. Independent variables included socio-demographic characteristics, comorbidity, lifestyles and healthcare resource utilization. Using logistic multivariate regression models, we analyzed the temporal evolution of psychotropic medication consumption between 2006 and 2012 in both sexes; Results: The prevalence of psychotropic drug use was significantly greater in women (18.14% vs. 8.08% in 2012 (p < 0.05). In Spanish women, the variables associated with a greater probability of psychotropic use were, age, unemployment (adjusted odds ratio (AOR), 1.60; 95% CI, 1.24–2.07), negative perception of health or taking non-psychotropic drugs. Among men, psychotropic use is associated with presence of chronic disease, negative perception of health (AOR, 3.27; 95% CI, 2.62–4.07 in 2012) or inactive status; Conclusions: Between 2006 and 2012, the probability of having taken psychotropic drugs increased by 16% among women. Unemployed women aged ≥45 years with a negative perception of their health constitute a clear risk profile in terms of psychotropic drug use. Inactive men who have a negative perception of their health are the group most likely to consume psychotropic drugs.

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“…b Any 12-month anxiety disorder includes panic, specific phobia, social phobia, agoraphobia, generalized anxiety, and post-traumatic stress disorder. had only one prescription generally covering < 6 months of treatment [1] and psychotropic drugs were discontinued in half of users during the first year of treatment [43]. The time-period of our study allows us to simultaneously consider regular users and those discontinuing therapy within the past 12 months, thereby reducing misclassification of those exposed to treatment.…”

Section: Discussionmentioning

confidence: 99%

Gender Differences in Psychotropic Use Across Europe: Results From a Large Cross-Sectional, Population-Based Study

et al. 2015

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Antidepressant prescribing in five European countries: application of common definitions to assess the prevalence, clinical observations, and methodological implications

Abstract: Despite applying uniform methods, variations in the prevalence of antidepressant prescribing were obvious in the different populations. Database characteristics and clinical factors may both explain these variations.

Cited by 137 publications

References 40 publications

Drug utilization patterns of antidepressants in Federal Neuro-Psychiatric Hospital Lagos, Nigeria

Drug utilization patterns of antidepressants in Federal Neuro-Psychiatric Hospital Lagos, Nigeria

Time Trend in Psychotropic Medication Use in Spain: A Nationwide Population-Based Study

Gender Differences in Psychotropic Use Across Europe: Results From a Large Cross-Sectional, Population-Based Study

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