Antidepressant medications

Leppien, Emily; Bystrak, Tamara; Doughty, Bennett

doi:10.1016/bs.seda.2020.08.007

Cited by 5 publications

(3 citation statements)

References 28 publications

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Section: Resultsmentioning

confidence: 99%

“…84 Tetracyclic antidepressants, such as mirtazapine, are not only reported to reduce psychological symptoms at low to moderate doses (15 to 45mg), but also to improve sleep and pruritus at low doses (7.5 to 30mg). 58,[85][86][87][88] In AD, dupilumab, has been shown to reduce symptoms of anxiety and depression as early as 2 weeks through inhibition of pro-inflammatory cytokines (IL-4, IL-12) and IgE. 89 Tralokinumab (anti IL-13) has been linked to overall QoL improvement in AD patients due to its proposed anti-pruritic, anti-depressant, anti-anxiety, and sedative effects.…”

Section: Atopic Dermatitismentioning

confidence: 99%

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The Mind Body Connection in Dermatologic Conditions: A Literature Review

Mar,

Rivers

2023

J Cutan Med Surg

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Psychodermatology pertains to the relationship between the skin and brain. This review aims to summarize the evidence of the mind body connection in four psychophysiological conditions: rosacea, atopic dermatitis (AD), acne vulgaris (AV), and psoriasis. A literature search was conducted using several English language databases. All four conditions share similar psychiatric co-morbidities, including but not limited to anxiety, depression, and suicidality. In rosacea, the upregulation of transient receptor potential vanilloid type 1, Toll like receptor 2, and Th17 cells releases downstream products that are simultaneously implicated in mood disorders. Stress exacerbates AV through the hypothalamic-pituitary-adrenal (HPA) system, which alters functioning of sebocytes and Cutibacterium acnes. In AD and psoriasis, the HPA axis influences Th1, Th2, Th22, and Th1, Th17 immune mediated responses, respectively. This leads to the secretion of pro-inflammatory cytokines which are also involved in the pathogenesis of anxiety and depression. Neurotransmitters implicated in mental illness, such as gamma-aminobutyric acid and serotonin, may also play a role in the development of AD and psoriasis. The management of cutaneous disease may mitigate psychological distress, and future research may show the corollary to also be true.

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Section: Resultsmentioning

confidence: 99%

Section: Atopic Dermatitismentioning

confidence: 99%

The Mind Body Connection in Dermatologic Conditions: A Literature Review

Mar,

Rivers

2023

J Cutan Med Surg

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“…1 The primary treatment approach for these mental health disorders involves the use of antidepressants. 2,3 It is indisputable that antidepressants can lead to Adverse Drug Reactions (ADRs). While these medications typically produce comparable effects, variations exist in their safety and the adverse reactions they may induce.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Adverse Drug Reactions in Treating Common Mental Health Disorders-Findings from a Tertiary Care Teaching Hospital in Puducherry

Jayasree,

Shanmuganathan,

Ramamurthy

et al. 2024

J. Young Pharm.

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Background: As per National Institute for Health and Care Excellence (NICE) guidelines, depression and anxiety are common mental health disorders. Antidepressants are used in the treatment of these disorders. It is well acknowledged that antidepressants can lead to Adverse Drug Reactions (ADRs). Comprehending the common ADRs linked to antidepressants is beneficial for improving patient safety, promoting rational prescribing practices and encouraging enhanced adherence to treatment. Purpose: To analyze the incidence of adverse drug reactions and evaluate their causality, severity and predictability for medications utilized in the treatment of common mental health disorders. Materials and Methods: This prospective longitudinal observational study was conducted in a tertiary care teaching hospital in Puducherry from July 2020 to November 2023. The participants were patients diagnosed with a common mental health disorder as per DSM-5. Participants were monitored for ADRs during every follow-up visit for 6 months from the baseline visit. Results: This research enrolled 216 patients and data from 144 patients who attended at least one follow-up appointment during the six-month follow-up period were included in the analysis. The overall incidence rate of ADRs was found to be 38.2%. Selective Serotonin Inhibitors (SSRIs) contributed to over 60% of the reported ADRs. The majority of reactions were classified as possible (85.8%) in causality assessment and a noteworthy proportion of these reactions were mild (63.2%) and predictable (91.5%). Conclusion: The research reveals a 38.2% incidence rate of ADRs. Majority of the ADRs were 'possible' , 'mild' and 'predictable' . Ongoing surveillance can aid in the detection, mitigation and prevention of ADRs.

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