Antidepressant medication prescribing patterns in Irish general practice from 2016 to 2020 to assess for long-term use

McCool, Aoibhin; Lukas, Kurt; Hayes, Peter; Kelly, Dervla

doi:10.1007/s11845-021-02833-7

Cited by 11 publications

(9 citation statements)

References 23 publications

(21 reference statements)

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“…Nevertheless, the incidence rate remained approximately stable in the same period (29). Similar data on the incidence and prevalence of antidepressant utilization were also reported by other studies in different countries (11, 13, 16, 27, 28). Thus, these results may indicate that the rise in prevalence could be due, at least partially, to an increased mean treatment duration rather than a higher number of patients being prescribed antidepressants.…”

Section: Introductionsupporting

confidence: 88%

“…In the last two decades, various epidemiological studies have shown an increased prevalence of antidepressant prescriptions in industrialized countries (11)(12)(13)(14)(15)(16)(17). This could be due to an increased prevalence of current mental disorders (18,19), which may also be due to primary care physicians' improved ability to recognize these disorders and promptly begin pharmacological treatment.…”

Section: Introductionmentioning

confidence: 99%

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Global prevalence of antidepressant utilization in the community: A protocol for a systematic review

Lunghi

Dugas

Leclerc

et al. 2022

Preprint

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Background Antidepressant drugs are the most frequently prescribed medication for mental disorders. They are also used off-label and for non-psychiatric indications. Prescriptions of antidepressants have increased in the last decades, but no systematic review exists on the extent of their use in the community. Methods and analysis We will conduct a systematic review to estimate the prevalence of antidepressant use in the community. We will search for studies published from 2010 in the Embase and MEDLINE databases. Study selection (by title/abstract and full-text screening) and data extraction for included studies will be independently conducted by pairs of reviewers. We will then synthesize the data on the prevalence of antidepressant use in individuals living in the community. If possible, we will perform a meta-analysis to generate prevalence-pooled estimates. If the data allows it, we will conduct subgroup analyses by antidepressant class, age, sex, country or other sociodemographics. We will evaluate the risk of bias for each included study through a quality assessment using the Joanna Briggs Institute Critical Appraisal tool: Checklist for Studies Reporting Prevalence Data. DistillerSR software will be used for the management of this review. Ethics and dissemination Ethical approval is not required for this review as it will not involve human or animal subjects. The findings of our systematic review will be disseminated through publications in peer-reviewed journals, the Qualaxia Network (https://qualaxia.org), presentations to international conferences on mental health and pharmacoepidemiology, as well as general public events. PROSPERO registration details CRD42021247423

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Section: Introductionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Global prevalence of antidepressant utilization in the community: A protocol for a systematic review

Lunghi

Dugas

Leclerc

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Nevertheless, the incidence rate remained approximately stable in the same period 29. Similar data on the incidence and prevalence of antidepressant utilization were also reported by other studies in different countries 11 13 16 27 28. Thus, these results may indicate that the rise in prevalence could be due, at least partially, to an increased mean treatment duration rather than a higher number of patients being prescribed antidepressants.…”

Section: Introductionsupporting

confidence: 85%

“…In the last two decades, various epidemiological studies have shown an increased prevalence of antidepressant prescriptions in industrialized countries 11–17. This could be due to an increased prevalence of current mental disorders,18 19 which may also be due to primary care physicians’ improved ability to recognise these disorders and promptly begin pharmacological treatment.…”

Section: Introductionmentioning

confidence: 99%

Global prevalence of antidepressant drug utilization in the community: protocol for a systematic review

et al. 2022

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IntroductionAntidepressant drugs are the most frequently prescribed medication for mental disorders. They are also used off-label and for non-psychiatric indications. Prescriptions of antidepressants have increased in the last decades, but no systematic review exists on the extent of their use in the community.Methods and analysisWe will conduct a systematic review to estimate the prevalence of antidepressant use in the community. We will search for studies published from 1 January 2010 in the Embase and MEDLINE databases using a combination of controlled vocabulary and keywords adjusted for each database without any language restriction. The main inclusion criterion is the presence of prevalence data of antidepressant utilization. Thus, we will include all studies with a descriptive observational design reporting the prevalence of antidepressant use in the community. Study selection (by title/abstract and full-text screening) and data extraction for included studies will be independently conducted by pairs of reviewers. We will then synthesize the data on the prevalence of antidepressant use in individuals living in the community. If possible, we will perform a meta-analysis to generate prevalence-pooled estimates. If the data allows it, we will conduct subgroup analyses by antidepressant class, age, sex, country and other sociodemographic categories. We will evaluate the risk of bias for each included study through a quality assessment using the Joanna Briggs Institute Critical Appraisal tool: Checklist for Studies Reporting Prevalence Data. DistillerSR software will be used for the management of this review.Ethics and disseminationEthical approval is not required for this review as it will not directly involve human or animal subjects. The findings of our systematic review will be disseminated through publications in peer-reviewed journals, the Qualaxia Network (https://qualaxia.org), presentations at international conferences on mental health and pharmacoepidemiology, as well as general public events.PROSPERO registration numberCRD42021247423.

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“…This study shows that long-term use compared to short-and medium-term use is highly substantial and, in line with previous ndings, long-term use has steadily increased between 2014 and 2020. [14,16,28,29] Recent studies, however, have reported a smaller proportion of long-term users [5,14], which could also be explained by the different de nitions of long-term use. In our study, the prescription duration of long-term users ranged from more than one year to eight years.…”

Section: Discussionmentioning

confidence: 99%

Trends in long-term use of antidepressants in Switzerland and associated factors between 2013 and 2021

Amrein

Hengartner

Näpflin

et al. 2023

Preprint

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Purpose: Antidepressant use has increased in many European countries, mostly driven by longer treatment duration. The aim of this study was to provide prevalence rates of long-term users of antidepressants for the Swiss population over the last decade and to investigate associated factors for longer use. Methods: We examined the prevalence rates of individuals with at least one prescription for antidepressants using longitudinal health claims data. To compare different lengths of prescription duration, we defined short-term (<6 months), medium-term (6-12 months) and long-term users (>12 months). We applied a binary logistic regression model to investigate the effects of population characteristics and treatment patterns on long-term compared to short- and medium-term users. Results: In 2021, 9% of the Swiss population (n=770 698) received at least one antidepressant prescription. This one-year-prevalence remained stable since 2013. In 2020, the proportion of long-term users was 69.4%, with steady increase from 2014 to 2020. The numbers of medium- and short-term users have decreased during this period. Older age, being a woman, living in an urban area, living in the Italian speaking part of Switzerland, living in a nursing home, being enrolled in a standard care plan, and receiving psychiatric or psychotherapeutic care were factors associated with long-term users. Conclusions: The proportion of long-term users in Switzerland is steadily increasing. Taking antidepressants longer than recommended may indicate possible overprescribing. Given the ongoing debate about the confounding effects of relapse and withdrawal, more research is needed to investigate antidepressants overprescribing, particularly for older people.

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Antidepressant medication prescribing patterns in Irish general practice from 2016 to 2020 to assess for long-term use

Cited by 11 publications

References 23 publications

Global prevalence of antidepressant utilization in the community: A protocol for a systematic review

Global prevalence of antidepressant utilization in the community: A protocol for a systematic review

Global prevalence of antidepressant drug utilization in the community: protocol for a systematic review

Trends in long-term use of antidepressants in Switzerland and associated factors between 2013 and 2021

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