Antidepressant-like Potential of Sida tiagii Bhandari Fruits in Mice

Abstract

The present study was undertaken to investigate the effects of different fruit extracts of Sida tiagii Bhandari (Family: Malvaceae), popularly known as Kharinti, on depressive behaviors in mice using forced swim test (FST) and tail suspension test (TST). Extracts were prepared by partitioning of 90% alcoholic extract with n-hexane (HS) and ethyl acetate (EAS) successively and were administered orally for 20 successive days to separate groups of Swiss young male albino mice. HS showed a dose dependent effect on immobility period while residual ethanolic extract (RES) showed the most potent antidepressant effect at all three doses. Chronic administration of EAS showed a variable effect (ineffective in TST while reversal in FST) at 200 and 500 mg/kg doses. RES significantly reduced the immobility times of mice in both FST and TST, without any significant effect on locomotive activity at all doses (100, 200, 500 mg/kg). The efficacy of RES was found to be comparable to that of imipramine (15 mg

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“…In the end, the derivative ethyl 2-[(3-nitropyridin-2-yl)sulfanyl]acetate was shown to decrease the immobility time of mice in the FST without affecting locomotor activity; unfortunately, no mechanism was proposed [342]. Sida tiagii showed activity in the FST and TST, acting through the inhibition of both MAO (more selectivity on MAO-A than on MAO-B) and lipid peroxidation [343]. Siphocampylus verticillatus was also studied for its potential antidepressant-like effect in 2 models in mice and against synaptosomal uptake of 5-HT, NA, and DA.…”