Antidepressant‑like effects of Z‑ligustilide on chronic unpredictable mild stress‑induced depression in rats

Antidepressant‐like effects of aqueous extracts of miswak ( Salvadora persica ) and date palm ( Phoenix dactylifera ) on depression‐like behaviors using CUMS model in male rats

“…Stress is the main risk factor for depression and other mental illnesses. Chronic unpredictable mild stress (CUMS) models are designed to imitate human depression (Ma et al, 2021). CUMS decreases the sensitivity of serotonin neurotransmission and its receptors in the hippocampus and medial prefrontal cortex, which, in turn, leads to developing depressive phenotypes such as hippocampal neurogenesis, despair, and anhedonia (Lages et al, 2021).…”

Medicine–food herb:Angelica sinensis, a potential therapeutic hope for Alzheimer's disease and related complications

“…95 Jian-Chun Ma found that the levels of progesterone and allopregnanolone in the prefrontal cortex and hippocampus were markedly increased after z-galactone treatment, indicating that z-galactone had an anti-depressant effect. 96 A previous study confirmed that coniferyl ferulate treatment can alleviate depression-like behaviors and the potential anti-depression mechanism was proven to be associated with the inhibition of the NMDAR-CaMKII-MAPK signaling pathway. 97 Besides, oral the administration of coniferyl ferulate could treat CUMS-induced depression via lowing IL-6, IL-1β, and TNF-α, restructuring the gut microbiome, and microbial metabolism.…”

Xiaoyaosan Ameliorates Chronic Restraint Stress-Induced Depression-Like Phenotype by Suppressing A2AR Signaling in the Rat Striatum

“…The rats were placed into plastic cylinder (50 cm deep, 20 cm in diameter) filled with water at 23–25°C up to a height of 30 cm from the base, and forced to swim for 6 min. The time of immobility behaviors (rat floating on the surface of the water, immobility of limbs, or slight body wiggling to maintain its balance) was calculated in the last 4 min ( Ma et al, 2021 ).…”