Antidepressant‐like effects of aqueous extracts of miswak (
            <i>Salvadora persica</i>
            ) and date palm (
            <i>Phoenix dactylifera</i>
            ) on depression‐like behaviors using
            <scp>CUMS</scp>
            model in male rats

Youssef, Basma; Ramadan, Kholoud S.; ElShebiney, Shaimaa A.; Ibrahim, E.

doi:10.1111/jfbc.14164

Cited by 9 publications

(9 citation statements)

References 71 publications

(82 reference statements)

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“…Furthermore, compared to the cigarette smoke group, administration of S. persica extract significantly ( p < 0.05) increased the amount of time spent in the open arm and the number of entries to the open arm at doses of 100 mg/kg and 200 mg/kg. Similar results were found in a study by the date palm and miswak aqueous extracts, which had antidepressant-like effects on depression-like behaviors in the model in rats and significantly ( p < 0.05) increased the number of entries in the open arm [ 32 ]. According to a study by Biradar [ 33 ], utilizing the EPM model, Sp extract's administration significantly reduced transfer latency (TL).…”

Section: Discussionsupporting

confidence: 87%

“…According to a study by Biradar [33], utilizing the EPM model, Sp extract's administration signifcantly reduced transfer latency (TL). Tus, administration of Sp generated an anxiolytic-like efect that was refected by a decrease in depressive-like behavior, which is consistent with other research studies that were conducted [31][32][33][34]. Tus, it is proving that the anxiolytic drugs exhibit improved performance in open arm exploration and the anxiogenic compounds work opposite by decreasing the entries to the open arm in the plus maze [35].…”

Section: Discussionsupporting

confidence: 86%

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Antidepressant and Anxiolytic Potentials of the Chewing Stick, Salvadora persica

Vasudevan

Kandasamy

Aldahish

et al. 2023

Journal of Tropical Medicine

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Purpose and Objectives. The quest for psychoactive plants possessing therapeutic potential has evolved emerging interest. Salvadora persica (Sp), belonging to the Salvadoraceae family, known as miswak, is a medicinal plant; most of its published research is on oral health, with promising antimicrobial, anti-inflammatory, and antiproliferative activity. However, given its widespread use, only few studies are associated with its potential neuropharmacological effect. Therefore, this study aims to assess the possible anxiolytic and antidepressant effects of Salvadora persica using animal models. Materials and Methods. Salvadora persica stem bark was extracted with two different solvents, i.e., ethyl acetate and water, and preliminary phytochemical screening was performed. Two behavioral models were used: an elevated plus maze test (EPM) and the light and dark model test for anxiolytic parameters, and a forced swim test (FST) for antidepressant effects. Healthy mice weighing 18−40 gms were treated orally in four groups (n = 6), i.e., negative control treated with normal saline and positive control with 1 mg/kg diazepam (EPM) and 30 mg/kg fluoxetine (FST), and the test groups were treated with 500 mg/kg of aqueous and ethyl acetate Sp extract. The number of entries and duration spent in the open arm for 5 minutes were the parameters for evaluating the anxiolytic activity (EPM). Duration of immobility was measured for 5 min in the FST model. Results. In EPM, both the Sp extracts significantly ( p < 0.005) increased the number of entries and the time spent in the open arms and was much similar to those of diazepam. Similarly, these extracts and fluoxetine significantly ( p < 0.005) decreased the immobility time in FST. Conclusion. The results suggest the therapeutic potential of Salvadora persica an alternative in the management of comorbid anxiety and depression.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 86%

Antidepressant and Anxiolytic Potentials of the Chewing Stick, Salvadora persica

Vasudevan

Kandasamy

Aldahish

et al. 2023

Journal of Tropical Medicine

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“…The chronic unpredictable mild stress-induced anxiety and depression-like rat model was established successfully, consistent with previous reports (Liang et al, 2019). Influenced by anxiety and depression, CUMS rats exhibit reduced diet and weight loss, as previously reported Zhou et al, 2021;Youssef et al, 2022). The weight loss in the CUMS rats was consistent with weight loss during depression in humans (Trief et al, 2014;Fernandez-Mendoza et al, 2015).…”

Section: Discussionsupporting

confidence: 87%

Mingmu Xiaoyao granules regulate the PI3K/Akt/mTOR signaling pathway to reduce anxiety and depression and reverse retinal abnormalities in rats

Zhou²,

Yang³

et al. 2022

Front. Pharmacol.

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Objective: To investigate the effects of Mingmu Xiaoyao granules (MMXY) on the morphology and function of the retina and the mechanism of PI3K/Akt/mTOR pathway-related proteins in rats with anxiety and depression induced by chronic unpredictable mild stress (CUMS).Methods: Fifty-two male Sprague Dawley rats were randomly allocated to either a control (n = 14) or a simulated CUMS group (n = 38). The CUMS model was established successfully at 4 weeks. Six rats in each group were randomly selected to be sacrificed and their retinas isolated for histological examination. At 5 weeks, rats in the CUMS group were randomly allocated to the following groups: Model (CUMS + pure water), MMXY-H (CUMS + MMXY 7.2 g/kg/d), MMXY-L (CUMS + MMXY 3.6 g/kg/d), and CBZ (CUMS + Carbamazepine 20 mg/kg/d), with eight rats in each group. All rats were given the relevant intervention once a day. At 12 weeks, sucrose preference and open field tests were performed to evaluate the anxiety and depression status of rats. In live rats, optical coherence tomography angiography was used to measure retinal thickness and blood flow, while electroretinograms (ERGs) and visual evoked potentials (VEPs) were used to evaluate retinal function. The next day, the specimens were sacrificed for serological, histological, immunofluorescence, Western blot and transmission electron microscopy examinations to explore the mechanism of MMXY in CUMS rats.Results: MMXY improved the anxiety and depression-like behavior of rats. Results of optical coherence tomography angiography showed that MMXY improved retinal inner thickness and blood flow in CUMS rats. MMXY improved the amplitude of a- and b-waves in the scotopic and photopic ERG, as well as N2 and P2 peak time and amplitude in the flash-VEP in CUMS rats. Retinal histological staining and transmission electron microscopy showed that MMXY reversed retinal morphology and ultrastructure in CUMS rats. MMXY reduced the expression of Beclin1 and LC3I/II proteins, regulated the PI3K/Akt/mTOR pathway, inhibited autophagy, and had a protective effect on the retina in CUMS rats.Conclusion: MMXY may effectively improve retinal morphology and function as well as anxiety and depression-like behaviors in CUMS rats by regulating the PI3K/Akt/mTOR signaling pathway.

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“…The rate of modeling is also low and symptoms are unstable [21]. The CUMS-induced rat model used in the present study displayed signs of depression, which was accompanied by pleasure de cit symptoms, as previously reported [22].…”

Section: Discussionsupporting

confidence: 83%

β-Asarone Promotes Autophagy by Inhibiting the PI3K/Akt/mTOR Pathway in a Rat Model of Depression in Parkinson’s Disease

Wang,

Zhang

et al. 2022

Preprint

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Depression in Parkinson’s disease (DPD) is a major non-motor symptom of Parkinson’s disease (PD), and is accompanied by monoamine neurotransmitter degradation in DPD rats. Autophagy is neuroprotective because it helps degrade abnormal deposition of α-synuclein (α-syn). The PI3K/Akt/mTOR pathway is a key autophagy pathway. β-Asarone, derived from Acorus tatarinowii Schott, has anti-PD and anti-depression effects. This study aimed to investigate the mechanism of action of β-asarone in the treatment of DPD model rats. We found that oral administration of β-asarone (7.5, 15, and 30 mg/kg) for 4 weeks increased dopamine, L-DOPA (levodopa; L-3,4-dihydroxyphenylalanine), and serotonin levels in the midbrain and decreased α-syn levels in DPD model rats compared with model group. As the neurotransmitter levels changed, the expression of Beclin-1 increased while that of p62 decreased in β-asarone-treated DPD rats compared with that in controls. Transmission electron microscopy (TEM) showed that β-asarone treatment also improved the number of autophagosomes and decreased mitochondrial damage in the striatum compared with that in untreated animals. These results suggest that β-asarone activates autophagy. Furthermore, western blotting and transmission electron microscopy analyses revealed that the PI3K/Akt/mTOR pathway played an important role in β-asarone treatment-induced activation of autophagy. Furthermore, β-asarone increased the levels of Beclin-1 protein and reduced the expression of p62, p-PI3K, p-AKT, and p-mTOR in the hippocampus. Lastly, transmission electron microscopy results demonstrated that the β-asarone-treated animals displayed abundant autophagosomes in the prefrontal cortex. These findings suggest that β-asarone exerts neuroprotective effects in this DPD model via the promotion of autophagy, and may be an effective therapeutic agent for DPD treatment.

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Antidepressant‐like effects of aqueous extracts of miswak ( Salvadora persica ) and date palm ( Phoenix dactylifera ) on depression‐like behaviors using CUMS model in male rats

Cited by 9 publications

References 71 publications

Antidepressant and Anxiolytic Potentials of the Chewing Stick, Salvadora persica

Antidepressant and Anxiolytic Potentials of the Chewing Stick, Salvadora persica

Mingmu Xiaoyao granules regulate the PI3K/Akt/mTOR signaling pathway to reduce anxiety and depression and reverse retinal abnormalities in rats

β-Asarone Promotes Autophagy by Inhibiting the PI3K/Akt/mTOR Pathway in a Rat Model of Depression in Parkinson’s Disease

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