Antidepressant-like effects of tea polyphenols on mouse model of chronic unpredictable mild stress

Liu, Yi; Jia, Genguang; Gou, Lingshan; Sun, Lingyan; Fu, Xiangyu; Lan, Nuo; Li, Sai; Yin, Xiaoxing

doi:10.1016/j.pbb.2012.12.024

Cited by 66 publications

(28 citation statements)

References 35 publications

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“…CUMS procedures were performed as previously described with some modifications. The mice in the experimental groups were subjected to CUMS for five consecutive weeks.…”

Section: Methodsmentioning

confidence: 99%

“…This test was performed as previously described to determine anhedonia, one of the core symptoms of major depression in humans. Briefly, during the acclimation period 72 h before the test, the mice were given ad libitum access to two bottles of 1% sucrose solution w/v for the first 24 h, followed by the replacement of one bottle of sucrose solution with tap water for the second 24 h. Subsequently, the mice were deprived of water and food for the third 24 h. The test was then performed, in which the mice were permitted ad libitum access to 100 mL of sucrose solution (1%, w/v) and 100 mL of tap water, with food deprivation.…”

Section: Methodsmentioning

confidence: 99%

“…This test was performed with minor modifications . The mice were suspended with both acoustic and visual isolation 50 cm above the floor by the tail with adhesive tape (1 cm from the tip) for 6 min.…”

Section: Methodsmentioning

confidence: 99%

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Orientin improves depression‐like behavior and BDNF in chronic stressed mice

Liu

Lan

Ren

et al. 2015

Molecular Nutrition Food Res

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“…CUMS procedures were performed as previously described with some modifications. The mice in the experimental groups were subjected to CUMS for five consecutive weeks.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Orientin improves depression‐like behavior and BDNF in chronic stressed mice

Liu

Lan

Ren

et al. 2015

Molecular Nutrition Food Res

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“…These re-sults are consistent with the statements that some polyphenol-rich plants produce antidepressant-like effects. This may be due to their antioxidant activity and altered monoaminergic responses [27].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Chaenomeles Maulei Fruit Juice Effects in Tests for Depression and Anxiety

Borisova

Eftimov

Valcheva-Kuzmanova

2019

Acta Medica Bulgarica

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Depression and anxiety are prevalent chronic psychiatric disorders affecting many people worldwide. Over the past decades, much attention has been drawn to herbal psychopharmacology, offering fewer adverse reactions. The main bioactive compounds in Chaenomeles maulei fruits are polyphenols known for their behavioral effects. The objective of the present study was to assess Chaenomeles maulei fruit juice (CMFJ) effects in tests for anxiety and depression. The animals used were 32 male healthy Wistar rats treated orally with CMFJ for 16 days. They were divided in four groups of 8 animals. The control group received distilled water and the rest of the groups were treated with CMFJ at 2.5, 5 and 10 ml/kg doses. We assessed the social interaction time as a measure of anxiety and the immobility time in the forced swim test as a measure of behavioral despair. In the social interaction test, the 14 days administration of CMFJ did not produce any significant changes in the time spent in social interaction. After 16 days of administration all doses of CMFJ significantly decreased the immobility time of the rats (p < 0.05) in comparison to the control group. These results allow making the conclusion that CMFJ lacked anxiolytic activity, but showed an antidepressant-like effect.

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“…FST was carried out as previously described (Liu, Jia, Gou, Sun, Fu, Lan, Li, & Yin, 2013;El Yacoubi, Bouali, Popa, Naudon, Leroux-Nicollet, Hamon, Costentin, Adrien, & Vaugeois, 2003) with a slight modification. Mice were placed individually into a vertical acrylic cylinder (25 cm high; 10 cm in diameter) filled with 10-cm-deep water (21-22˚C).…”

Section: Fstmentioning

confidence: 99%

A Possibility that a Deficiency in Dietary Fiber Causes Depression

Abe¹

2016

IJHS

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The aim of the present study was to clarify whether a deficiency in dietary fiber intake causes depression by analyzing behavior of mice in the forced swim test (FST). The FST is widely used to evaluate the activity of antidepressant drugs. In the test, immobility of mice is considered as depression-like behavior. Mice were divided into two groups: experimental group and control group. A cellulose deficient diet that contained no cellulose was given to the mice of the experimental group, and a diet that contains 5.0% cellulose was given to the mice of the control group. After 3 or 4 weeks, immobility times of the mice in the experimental group were significantly longer than those in the control groups. On the other hand, there were no significant differences in body weights between the mice in the two groups. Based on these results, it is speculated that a deficiency in dietary fiber intake causes depression by factors other than obesity.

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Antidepressant-like effects of tea polyphenols on mouse model of chronic unpredictable mild stress

Cited by 66 publications

References 35 publications

Orientin improves depression‐like behavior and BDNF in chronic stressed mice

Orientin improves depression‐like behavior and BDNF in chronic stressed mice

Assessment of Chaenomeles Maulei Fruit Juice Effects in Tests for Depression and Anxiety

A Possibility that a Deficiency in Dietary Fiber Causes Depression

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