Orientin improves depression‐like behavior and BDNF in chronic stressed mice

Liu, Yi; Lan, Nuo; Ren, Jing; Wu, Yizhen; Wang, Shuting; Huang, Xu‐Feng; Yu, Yinghua

doi:10.1002/mnfr.201400753

Cited by 56 publications

(37 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Gluten peptides from wheat flour have also been shown to contribute to higher hypothalamic and cortical serotonin levels in animal models [ 44 ]. Phenolic compounds can also play an important role in appetite suppression by stimulating this important signalling molecule [ 45 ]. Furthermore, Maillard reaction products such as N(ε)-carboxymethyl lysine from heat-treated foods like biscuits, have been found to contribute to satiety regulation through central/brain serotonin release in SH-SY5Y cells [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

Biscuits with No Added Sugar Containing Stevia, Coffee Fibre and Fructooligosaccharides Modifies α-Glucosidase Activity and the Release of GLP-1 from HuTu-80 Cells and Serotonin from Caco-2 Cells after In Vitro Digestion

et al. 2017

View full text Add to dashboard Cite

This study assessed the in vitro effects of the bioaccessible food components released during the simulated human digestion of a coffee fibre-containing biscuit (CFB) on α-glucosidase activity, antioxidant capacity and satiety hormones. Digest of CFB presented a significantly (p < 0.05) lower amount of sugar (68.6 mg/g) and a higher antioxidant capacity (15.1 mg chlorogenic acid eq./g) than that of a sucrose-containing biscuit (SCB). The CFB significantly reduced (p < 0.05) α-glucosidase activity (IC50 = 3.3 mg/mL) compared to the SCB (IC50 = 6.2 mg/mL). Serotonin and glucagon-like peptide-1 (GLP-1) release by differentiated Caco-2 and HuTu-80 cells, respectively, was stimulated by the CFB (355% at a concentration of 0.5 mg/mL and 278% at a concentration of 0.05 mg/mL) to the same order of magnitude as those of the SCB. To summarize, the CFB was demonstrated to reduce monosaccharide bioaccessibility, to inhibit a diabetes-related digestive enzyme, and to improve the release of satiety hormones.

show abstract

Section: Resultsmentioning

confidence: 99%

Biscuits with No Added Sugar Containing Stevia, Coffee Fibre and Fructooligosaccharides Modifies α-Glucosidase Activity and the Release of GLP-1 from HuTu-80 Cells and Serotonin from Caco-2 Cells after In Vitro Digestion

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Liang, Zhang, Su, Williams, and Li () described the C‐ glycosyl flavones as a possibility of new lead candidates with a novel mechanism of action for the development of Alzheimer's disease. The antidepressant‐like effects of C‐ glycosyl flavonoids were described for vitexin, underlying its monoaminergic mechanisms (Can, DemirÖzkay, & Üçel, ); and for orientin, with improvement of central oxidative stress, neurotransmission and neuroplasticity (Liu et al, ). Orientin also showed protective effects on noise‐induced cognitive decline in mice, specifically by improving central oxidative stress and neurotransmission, and increased synapse‐associated proteins (Wang et al, ).…”

Section: Resultsmentioning

confidence: 99%

LC/QTOF profile and preliminary stability studies of an enriched flavonoid fraction of Cecropia pachystachya Trécul leaves with potential antidepressant‐like activity

Ortmann

Abelaira

Réus

et al. 2017

Biomedical Chromatography

View full text Add to dashboard Cite

There is increasing interest in natural antioxidants that are candidates for the prevention of brain damage occurring in major depressive disorders. Cecropia pachystachya is a tropical tree species of Central and South America and a rich source of polyphenols, particularly flavonoids. The aim of this study was to characterize the flavonoid profile of an enriched flavonoid fraction of C. pachystachya (EFF-Cp) and evaluate the antidepressant-like effects of its acute administration in behavior, cytokine levels, oxidative stress and energy metabolism parameters. The EFF-Cp chemical characterization was performed by HPLC/DAD and LC/QTOF. The antidepressant-like effects were performed by the forced swimming test, splash test and open field test. EFF-Cp revealed 15 flavonoids, including seven new glycosyl flavonoids for C. pachystachya. Quantitatively, EFF-Cp showed isoorientin (43.46 mg/g), orientin (23.42 mg/g) and isovitexin (17.45 mg/g) as major C-glycosyl flavonoids. In addition, EFF-Cp at doses 50 and 100 mg/kg reduced the immobility time in the forced swimming test, without changing the locomotor activity and grooming time. In addition, EFF-Cp was able to prevent the oxidative damage in some brain areas. In conclusion, the results of this study suggest that EFF-Cp exerts antidepressant-like effects with its antioxidant properties.

show abstract

“…BDNF plays an important role on neuronal survival, neurogenesis, differentiation of neurons and synapses, learning and memory 62 . Interestingly, BDNF was decreased in hippocampus and prefrontal cortex of patients with depressive-like symptoms and other psychiatric disorders 63 . Increased BDNF expression could largely improve depressive disorders 64 .…”

Section: Discussionmentioning

confidence: 99%

Puerarin ameliorated the behavioral deficits induced by chronic stress in rats

Qiu

Zhang

Zhong

et al. 2017

Sci Rep

View full text Add to dashboard Cite

The present study aimed to investigate the mechanisms underlying the antidepressant-like effects of puerarin via the chronic unpredictable stress (CUS) procedure in rats. Similar to Sertraline (Ser), Chronic treatment of puerarin (60 and 120 mg/kg, i.g) elicited the antidepressant-like effects by reversing the decreased sucrose preference in sucrose preference test (SPT), by blocking the increased latency to feed in novelty-suppressed feeding test (NSFT) and the increased immobility time in forced swimming test (FST) without affecting locomotor activity. However, acute puerarin treatment did not ameliorate the antidepressant- and anxiolytic- like effects in FST and NSFT, respectively. In addition, enzyme linked immunosorbent assay (ELISA) and high performance liquid chromatography-electrochemical detection (HPLC-ECD) showed that chronic treatment of puerarin (60 and 120 mg/kg, i.g) reversed the decreased levels of progesterone, allopregnanolone, serotonin (5-HT) and 5-Hydroxyindoleacetic acid (5-HIAA) in prefrontal cortex and hippocampus of post-CUS rats. Furthermore, puerarin (60 and 120 mg/kg, i.g) blocked the increased corticotropin releasing hormone (CRH), corticosterone (Cort) and adrenocorticotropic hormone (ACTH). Collectively, repeated administration of puerarin alleviated the behavioral deficits induced by chronic stress which was associated with the biosynthesis of neurosteroids, normalization of serotonergic system and preventing HPA axis dysfunction.

show abstract

Orientin improves depression‐like behavior and BDNF in chronic stressed mice

Cited by 56 publications

References 65 publications

Biscuits with No Added Sugar Containing Stevia, Coffee Fibre and Fructooligosaccharides Modifies α-Glucosidase Activity and the Release of GLP-1 from HuTu-80 Cells and Serotonin from Caco-2 Cells after In Vitro Digestion

Biscuits with No Added Sugar Containing Stevia, Coffee Fibre and Fructooligosaccharides Modifies α-Glucosidase Activity and the Release of GLP-1 from HuTu-80 Cells and Serotonin from Caco-2 Cells after In Vitro Digestion

LC/QTOF profile and preliminary stability studies of an enriched flavonoid fraction of Cecropia pachystachya Trécul leaves with potential antidepressant‐like activity

Puerarin ameliorated the behavioral deficits induced by chronic stress in rats

Contact Info

Product

Resources

About