Antidepressant-like effects of mild hypoxia preconditioning in the learned helplessness model in rats

Рыбникова, Е. А.; Mironova, V. I.; Pivina, S. G.; Tulkova, Ekaterina; Ordyan, N. É.; Vataeva, L. A.; Vershinina, E. A.; Abritalin, E. Yu.; Kolchev, A. I.; Nalivaeva, Natalia N.; Turner, Anthony J.; Самойлов, М. О.

doi:10.1016/j.neulet.2007.02.048

Cited by 39 publications

(18 citation statements)

References 21 publications

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“…31 The authors reported that the slowing of memory degradation could be achieved by limited increase in oxidative stress, restricted overproduction of brain nitrite oxide and the absence of injured neurons with pathomorphological changes or dead neurons. If hypoxic conditioning can protect the brain from chronic neurodegeneration, it could also be efficient against psychiatric disease such as depression 32,33 or post-stress depressive episodes. 34,35 The effect of hypoxic conditioning in epilepsy, a chronic brain dysfunction disease, has also been tested.…”

Section: Hypoxic Conditioning To Prevent Brain Functional Alterationsmentioning

confidence: 99%

Hypoxic conditioning and the central nervous system: A new therapeutic opportunity for brain and spinal cord injuries?

Baillieul

Chacaroun

Doutreleau

et al. 2017

Exp Biol Med (Maywood)

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Neuroprotection and brain recovery from either acute or chronic neurodegeneration still represent a challenge in neurology and neurorehabilitation. Hypoxic conditioning may represent a harmless and efficient non-pharmacological new therapeutic modality in the field of neuroprotection and neuroplasticity, as supported by many preclinical data. Animal studies provide clear evidence for neuroprotection and neuroplasticity induced by hypoxic conditioning in several models of neurological disorders. These studies show improved functional outcomes when hypoxic conditioning is applied and provides important information to translate this intervention to clinical practice. Some studies in humans provide encouraging data regarding the tolerance and therapeutic effects of hypoxic conditioning strategies. The main issues to address in future research include the definition of the appropriate hypoxic dose and pattern of exposure, the determination of relevant physiological biomarkers to assess the effects of the treatment and the evaluation of combined strategies involving hypoxic conditioning and other pharmacological or non-pharmacological treatments. AbstractCentral nervous system diseases are among the most disabling in the world. Neuroprotection and brain recovery from either acute or chronic neurodegeneration still represent a challenge in neurology and neurorehabilitation as pharmacology treatments are often insufficiently effective. Conditioning the central nervous system has been proposed as a potential non-pharmacological neuro-therapeutic. Conditioning refers to a procedure by which a potentially deleterious stimulus is applied near to but below the threshold of damage to the organism to increase resistance to the same or even different noxious stimuli given above the threshold of damage. Hypoxic conditioning has been investigated in several cellular and preclinical models and is now recognized as inducing endogenous mechanisms of neuroprotection. Ischemic, traumatic, or chronic neurodegenerative diseases can benefit from hypoxic conditioning strategies aiming at preventing the deleterious consequences or reducing the severity of the pathological condition (preconditioning) or aiming at inducing neuroplasticity and recovery (postconditioning) following central nervous system injury. Hypoxic conditioning can consist in single (sustained) or cyclical (intermittent, interspersed by short period of normoxia) hypoxia stimuli which duration range from few minutes to several hours and that can be repeated over several days or weeks. This mini-review addresses the existing evidence regarding the use of hypoxic conditioning as a potential innovating neuro-therapeutic modality to induce neuroprotection, neuroplasticity and brain recovery. This mini-review also emphasizes issues which remain to be clarified and future researches to be performed in the field.

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Section: Hypoxic Conditioning To Prevent Brain Functional Alterationsmentioning

confidence: 99%

Hypoxic conditioning and the central nervous system: A new therapeutic opportunity for brain and spinal cord injuries?

Baillieul

Chacaroun

Doutreleau

et al. 2017

Exp Biol Med (Maywood)

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“…These two models produce different outcomes in rodents (19). Brief IH stimulates neurogenesis and reduces depressive-like behaviors (34,54). However, negative outcomes, such as impaired cognitive functions, increased inflammation, and oxidative stress are more common following chronic IH (19,32,44).…”

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confidence: 99%

Dim light at night interacts with intermittent hypoxia to alter cognitive and affective responses

Aubrecht

Weil

Magalang

et al. 2013

American Journal of Physiology-Regulatory, Integrative and Comp

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Aubrecht TG, Weil ZM, Magalang UJ, Nelson RJ. Dim light at night interacts with intermittent hypoxia to alter cognitive and affective responses. Am J Physiol Regul Integr Comp Physiol 305: R78 -R86, 2013. First published May 8, 2013 doi:10.1152/ajpregu.00100.2013 and dim light at night (dLAN) have both been independently associated with alterations in mood and cognition. We aimed to determine whether dLAN would interact with intermittent hypoxia (IH), a condition characteristic of OSA, to alter the behavioral, cognitive, and affective responses. Adult male mice were housed in either standard lighting conditions (14:10-h light-dark cycle; 150 lux:0 lux) or dLAN (150 lux:5 lux). Mice were then exposed to IH (15 cycles/h, 8 h/day, FIO 2 nadir of 5%) for 3 wk, then tested in assays of affective and cognitive responses; brains were collected for dendritic morphology and PCR analysis. Exposure to dLAN and IH increased anxiety-like behaviors, as assessed in the open field, elevated plus maze, and the light/dark box. dLAN and IH increased depressive-like behaviors in the forced swim test. IH impaired learning and memory performance in the passive avoidance task; however, no differences were observed in spatial working memory, as assessed by y-maze or object recognition. IH combined with dLAN decreased cell body area in the CA1 and CA3 regions of the hippocampus. Overall, IH decreased apical spine density in the CA3, whereas dLAN decreased spine density in the CA1 of the hippocampus. TNF-␣ gene expression was not altered by IH or lighting condition, whereas VEGF expression was increased by dLAN. The combination of IH and dLAN provokes negative effects on hippocampal dendritic morphology, affect, and cognition, suggesting that limiting nighttime exposure to light in combination with other established treatments may be of benefit to patients with OSA.

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“…1,2 It is associated with a consistently high prevalence worldwide 3 and is one of the most important causes of morbidity and disability in developing countries. 4 However, therapy for depression has been plagued with inconsistent effi cacy of currently available regimens and untoward side-effects in a signifi cant number of patients.…”

Section: Introductionmentioning

confidence: 99%

Antidepressant-like properties of Antiaris toxicaria aqueous extract

Mante

Woode

Kukuia

et al. 2015

Int J Basic Clin Pharmacol

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Antidepressant-like effects of mild hypoxia preconditioning in the learned helplessness model in rats

Cited by 39 publications

References 21 publications

Hypoxic conditioning and the central nervous system: A new therapeutic opportunity for brain and spinal cord injuries?

Hypoxic conditioning and the central nervous system: A new therapeutic opportunity for brain and spinal cord injuries?

Dim light at night interacts with intermittent hypoxia to alter cognitive and affective responses

Antidepressant-like properties of Antiaris toxicaria aqueous extract

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