Antidepressant-like effect of nitric oxide synthase inhibitors and sildenafil against lipopolysaccharide-induced depressive-like behavior in mice

Tomaz, V.S.; Cordeiro, R.C.; Costa, Andréa Santos; Lucena, David Freitas de; Júnior, Hélio Vitoriano Nobre; Sousa, Francisca Cléa Florenço de; Vasconcelos, Silvânia Maria Mendes; Vale, Mariana Lima; Quevedo, João; Macêdo, Danielle Silveira

doi:10.1016/j.neuroscience.2014.03.025

Cited by 91 publications

(50 citation statements)

References 62 publications

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“…These results indicate that the antidepressant-like effect of quercetin may be also modulated by decreased cGMP. This fact is confirmed by the reversal of the antidepressant effect of quercertin by pretreatment of mice with sildenafil -a phosphodiesterase 5 selective inhibitor that increases the level of cGMP (Katarzyna et al, 2012;Tomaz et al, 2014;Rieger et al, 2014) -suggesting that administration of quercetin reduces the levels of cGMP. This may be the mechanism responsible for the effect on the tail suspension test.…”

Section: Discussionmentioning

confidence: 93%

Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways

Holzmann

Silva

et al. 2015

Pharmacology Biochemistry and Behavior

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Section: Discussionmentioning

confidence: 93%

Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways

Holzmann

Silva

et al. 2015

Pharmacology Biochemistry and Behavior

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“…Therefore, depressive behaviors were tested at 24 h after LPS exposure in the current study. As previously reported, the LPS dosage of 0.5 mg/kg [8,37,38] was selected for its ability to successfully induce depressive-like behaviors and neurochemical alterations in mice.…”

Section: Discussionmentioning

confidence: 99%

Hippocampal CysLT1R knockdown or blockade represses LPS-induced depressive behaviors and neuroinflammatory response in mice

et al. 2017

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Evidence suggests that neuroinflammation is involved in depression and that the cysteinyl leukotriene receptor 1 (CysLT 1 R) plays a potential pathophysiological role in several types of CNS disorders. Our previous study has shown that knockdown of hippocampal CysLT 1 R in mice prevents the depressive-like phenotype and neuroinflammation induced by chronic mild stress (CMS). Here, we examined the effects of hippocampal CysLT 1 R knockdown and CysLT 1 R blockade on LPS-induced depressive-like behavior in mice. We found that injection of LPS (0.5 mg/kg, ip) caused marked increase in hippocampal CysLT 1 R expression, which was reversed by pretreatment with fluoxetine (20 mg·kg -1 ·d -1 for 7 d, ig). Knockdown of hippocampal CysLT 1 R or blockade of CysLT 1 R by pretreatment with pranlukast (0.5 mg/kg, ip) significantly suppressed LPS-induced depressive behaviors, as evidenced by decreases in mouse immobility time in the forced swimming test (FST) and tail suspension test (TST) and latency to feed in the novelty-suppressed feeding (NSF) test. Moreover, both CysLT 1 R knockdown and CysLT 1 R blockade markedly prevented LPS-induced neuroinflammation, as shown by the suppressed activation of microglia and NF-κB signaling as well as the hippocampal levels of TNF-α and IL-1β in mice. Our results suggest that CysLT 1 R may be involved in LPS-induced depressive-like behaviors and neuroinflammation, and that downregulation of CysLT 1 R could be a novel and potential therapeutic strategy for the treatment of depression, at least partially due to its role in neuroinflammation.

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“…After acute stress, the increased level of COX-2 and iNOS expression is related to the increase in oxidative and nitrosative stress [28]. In addition, inhibitors of COX-2 [29] and inhibitors of iNOS [30] could ameliorate depressive-like behavior. In present study, apigenin attenuated levels of COX-2 and iNOS in PFC, suggesting that antidepressantlike effects of apigenin may be related to the decreased expression of iNOS and COX-2 in PFC.…”

Section: Discussionmentioning

confidence: 99%

The effects of apigenin on lipopolysaccharide-induced depressive-like behavior in mice

Zhao

et al. 2015

Neuroscience Letters

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Antidepressant-like effect of nitric oxide synthase inhibitors and sildenafil against lipopolysaccharide-induced depressive-like behavior in mice

Cited by 91 publications

References 62 publications

Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways

Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways

Hippocampal CysLT1R knockdown or blockade represses LPS-induced depressive behaviors and neuroinflammatory response in mice

The effects of apigenin on lipopolysaccharide-induced depressive-like behavior in mice

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