The effects of apigenin on lipopolysaccharide-induced depressive-like behavior in mice

Li, Ruipeng; Zhao, Di; Qu, Rong; Fu, Qiang

doi:10.1016/j.neulet.2015.03.040

Cited by 65 publications

(40 citation statements)

References 29 publications

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“…In the present study, we observed that these enzymes decrease in their activities in the myocardium of ISO-treated rats, which is in line with the previous study reported by Li et al. [75] and showed ISO-induced myocardial damage of the cardiac membrane. We found that 14-day treatment of AP significantly attenuated the activities of CK-MB isoenzyme and LDH in the myocardial tissue during ISO affront.…”

Section: Discussionsupporting

confidence: 94%

“…Not only the hemodynamic, electrocardiographic and ventricular functions, but also a number of diagnostic marker enzymes like creatinine kinase-MB isoenzyme and lactate dehydrogenase are present in myocardium and have been worn as a forecaster for pathological and internal changes. These enzymes are released from intracellular membranes into the extracellular fluid during the oxidative stress or myocardial injury [75,76]. In the present study, we observed that these enzymes decrease in their activities in the myocardium of ISO-treated rats, which is in line with the previous study reported by Li et al.…”

Section: Discussionsupporting

confidence: 93%

“…In the present study, we observed that the significant decrease in the activities of SOD, catalase and GSH level in ISOtreated rats, whereas treatment with AP significantly attenuated it. AP (75) showed more pronouncing effect. These verdicts are in harmony with studies reporting that AP has strong antioxidant activity [80].…”

Section: Discussionmentioning

confidence: 89%

“…AP dose-dependently counteracted the deleterious effect of ISO by decreasing the level of malondialdehyde and increasing the content of SOD (p [ 0.01), GSH (p [ 0.001) and catalase (p [ 0.001). AP (75) showed maximum protection against the antioxidant parameters (Fig. 4).…”

Section: Effect Of Ap On the Activities Of Catalase Gsh Sod And Mdamentioning

confidence: 93%

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Apigenin Attenuates β-Receptor-Stimulated Myocardial Injury Via Safeguarding Cardiac Functions and Escalation of Antioxidant Defence System

2015

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Apigenin (AP) is a flavone in dietary flavonoids reported as strong antioxidant and elite modulator of PPARγ. The current study evaluated the consequence of AP in isoproterenol (ISO)-induced oxidative stress and myocardial infarction during β-adrenergic receptor stimulus in rats by persistent hemodynamic, biochemical and histopathological changes. Rats received AP (25, 50 and 75 mg/kg/day) or vehicle i.p. for 14 days and ISO (100 mg/kg, s.c.) on 13th and 14th days for initiation of cardiotoxicity. ISO-treated rats showed evidence of significant dwindle in systolic and diastolic arterial pressures, maximal positive rate of developed left ventricular pressure. In totting up, a noteworthy diminution in activities of creatine kinase-MB isoenzyme, reduced glutathione, superoxide dismutase, catalase and level along with rise in malondialdehyde content were observed. The shielding function of AP on isoproterenol-induced myocardial damage was observed by attenuating all the endogenous parameters and the membrane-bound enzymes. It was confirmed by histopathological examinations. The effect of AP at the doses of 50 and 75 mg/kg showed added apparent than at the dose of 25 mg/kg. Current study thus provides confirmation for protective effects of AP on myocardium in experimentally induced myocardial infarction.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 89%

Section: Effect Of Ap On the Activities Of Catalase Gsh Sod And Mdamentioning

confidence: 93%

See 2 more Smart Citations

Apigenin Attenuates β-Receptor-Stimulated Myocardial Injury Via Safeguarding Cardiac Functions and Escalation of Antioxidant Defence System

2015

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“…Animal studies have largely supported these findings. For example, Fluoxetine blocks social stress or LPS-induced depressive behavior (Kaster et al., 2012), while the resulting inflammation is only modestly attenuated (Ji et al., 2014, Li et al., 2015, Zhu et al., 2015). …”

Section: Therapeutic Relevancementioning

confidence: 99%

Neuroinflammation at the interface of depression and cardiovascular disease: Evidence from rodent models of social stress

Finnell

Wood

2016

Neurobiology of Stress

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A large body of evidence has emerged linking stressful experiences, particularly from one's social environment, with psychiatric disorders. However, vast individual differences emerge in susceptibility to developing stress-related pathology which may be due to distinct differences in the inflammatory response to social stress. Furthermore, depression is an independent risk factor for cardiovascular disease, another inflammatory-related disease, and results in increased mortality in depressed patients. This review is focused on discussing evidence for stress exposure resulting in persistent or sensitized inflammation in one individual while this response is lacking in others. Particular focus will be directed towards reviewing the literature underlying the impact that neuroinflammation has on neurotransmitters and neuropeptides that could be involved in the pathogenesis of comorbid depression and cardiovascular disease. Finally, the theme throughout the review will be to explore the notion that stress-induced inflammation is a key player in the high rate of comorbidity between psychosocial disorders and cardiovascular disease.

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Umbelliferone attenuates unpredictable chronic mild stress induced‐insulin resistance in rats

Tao

Wang

et al. 2016

IUBMB Life

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The aim of this study was to investigate whether umbelliferone (Umb) could attenuate insulin resistance in unpredictable chronic mild stress (CUMS)-induced rats. Behavioral changes were evaluated through sucrose preference test (SPT), openfield test, forced swimming test, and tail suspension test (TST), suggesting that Umb (20 and 40 mg/kg) could effectively improve depression symptoms. Oral glucose tolerance test and serum insulin indicated that Umb attributed to the control of blood glucose levels. The phosphorylation of insulin receptor, insulin receptor substrate (IRS)21, glycogen synthase kinase-3b, PI3K, and Akt was increased in Umb (20 and 40 mg/kg) treatment according to Western blot analysis. Taken together, the current results suggested the ameliorative effect of Umb against insulin resistance in the CUMS-induced rats. V C 2016 IUBMB Life, 68(5): [403][404][405][406][407][408][409] 2016

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The effects of apigenin on lipopolysaccharide-induced depressive-like behavior in mice

Cited by 65 publications

References 29 publications

Apigenin Attenuates β-Receptor-Stimulated Myocardial Injury Via Safeguarding Cardiac Functions and Escalation of Antioxidant Defence System

Apigenin Attenuates β-Receptor-Stimulated Myocardial Injury Via Safeguarding Cardiac Functions and Escalation of Antioxidant Defence System

Neuroinflammation at the interface of depression and cardiovascular disease: Evidence from rodent models of social stress

Umbelliferone attenuates unpredictable chronic mild stress induced‐insulin resistance in rats

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