Antidepressant-like behavioral and neurochemical effects of the citrus-associated chemical apigenin

Yi, Long; Li, Jianmei; Li, Yucheng; Pan, Ying; Xu, Qing‐Long; Kong, Ling-Dong

doi:10.1016/j.lfs.2008.01.007

Cited by 102 publications

(79 citation statements)

References 65 publications

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“…In the same way, the total amount of apigenin glycosides in the effective dose of LAE was calculated to be 18.9 μmol/kg. This value is less than 37.0 μmol/kg, a reported oral dose of apigenin aglycone effective in the FST in mice, not acutely but after 14 days treatment (Yi et al, 2008). In addition, bioavailability of apigenin glycosides in rats might be lower than that of apigenin aglycone, because intestinal permeability of apigenin 7-O-glucoside, an apigenin glycoside found in lavender (Harborne and Williams, 2002), was reported to be much lower than that of apigenin aglycone in both the caco-2 cell culture model and perfused rat intestinal model (Liu and Hu, 2002).…”

Section: Concentration Of Linalool In Lae Before and After The Evapormentioning

confidence: 66%

“…Lavender has been reported to contain non-volatile phenolic compounds such as hydroxycinnamic acids and flavone glycosides (Harborne and Williams, 2002), which can be extracted by hot water and were possibly present in the LAE used in this study. Among the phenolic compounds previously found in lavender, apigenin, which is mostly present as a glycoside in lavender (Harborne and Williams, 2002), and rosmarinic acid have been reported to have an antidepressant-like activity in the FST (Takeda et al, 2002a;Takeda et al, 2002b;Nakazawa et al, 2003;Yi et al, 2008). In order to estimate the contribution of rosmarinic acid and apigenin glycosides to the antidepressant-like effects of LAE, the concentration of these compounds in LAE was determined (Table 2).…”

Section: Concentration Of Linalool In Lae Before and After The Evapormentioning

confidence: 99%

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Antidepressant-like Effects of an Aqueous Extract of Lavender (Lavandula angustifolia Mill.) in Rats

Kageyama

Ueno²,

Oshio

et al. 2012

FSTR

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The purpose of the present study was to examine the antidepressant-like effects of an aqueous extract of lavender (LAE) using the forced swimming test (FST), the most widely used animal model of depression. LAE was orally administered to rats three times, i.e., 24, 5, and 1 h prior to the FST. The administration of LAE (3428 mg/kg body weight) showed a significant reduction of the immobility time in the FST, the effect of which was comparable to that of the synthetic antidepressant, imipramine (30 mg/kg). In addition, the same dose of LAE did not change the locomotor activity in the open field test. These results suggest that LAE might have antidepressant-like effects that are independent of motor stimulation. Furthermore, the active ingredients of LAE were suggested to be non-volatile constituents, because linalool, the main aroma constituent of lavender, was completely removed during the preparation of LAE. Possible contribution of rosmarinic acid and that of apigenin glycosides to the antidepressant-like effects of LAE were discussed on the basis of their content in LAE.

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Section: Concentration Of Linalool In Lae Before and After The Evapormentioning

confidence: 66%

Section: Concentration Of Linalool In Lae Before and After The Evapormentioning

confidence: 99%

Antidepressant-like Effects of an Aqueous Extract of Lavender (Lavandula angustifolia Mill.) in Rats

Kageyama

Ueno²,

Oshio

et al. 2012

FSTR

View full text Add to dashboard Cite

show abstract

“…The other pathway related to the development of depression is neurotransmitter levels and ratios in the brain. [27][28][29][30] The FST trial significantly increased the metabolite/transmitter ratio (DOPAC/DA and 5-HIAA/5-HT) (Fig. 3).…”

Section: Discussionmentioning

confidence: 96%

Genistein Regulated Serotonergic Activity in the Hippocampus of Ovariectomized Rats under Forced Swimming Stress

Kageyama

Sakakibara

Zhou

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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“…The presence of such structurally similar flavonoids with opposing effects on motor activity may be the cause of antidepressant-like action with low doses followed by an increase in immobility time at higher doses of the extract (An et al, 2008). P. microphylla possesses profound antidepressant-like property at low doses and may be explored for developing antidepressant drugs derived from natural products.…”

Section: Ajabsmentioning

confidence: 99%

“…Interactions between monoamine neurotransmitters system including serotonin (5-hydroxytryptamine) (5-HT), Noradrenaline (NA) and Dopamine (DA) in the brain along with their specific reuptake and receptor protein has gain so much interest in the spectrum of antidepressant studies (Yi et al, 2008). In plants, serotonin has been found in a wide range of plant species.…”

Section: Introductionmentioning

confidence: 99%

Antidepressant-Like Effects of Selected Crude Extracts of Pilea microphylla in Mice Model of Depression

Chahardehi

Demirtaş

Abolhassani

et al. 2013

American Journal of Agricultural and Biological Sciences

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The present study was undertaken to investigate the effect of selected crude extracts namely, Methanol (ME I), Chloroform Extract (CE II) and Ethyl Acetate (EAE II) extracts of Pilea microphylla on depression in mice. In the present study, the antidepressant effect of P. microphylla was examined due to its rich flavonoid contents in the Urticaceae family using two behavioral models, the Forced Swimming Test (FST) and Tail Suspension Test (TST) in mice. Selected crude extracts from Pilea microphylla produced an antidepressant-like effect, since the acute treatment of mice with extracts by intraperitoneal (i.p.) route significantly reduced the immobility time in the FST (50 and 100 mg kg ), as compared to positive controls (haloperidol and fluoxetine) at 1 and 10 mg kg −1 , respectively. The results showed that ME I, CE II and EAE II at dose of 100 mg kg −1 of body weight decreased immobility time with the increase swimming time with respect to the first day (p<0.05). Among all the three selected extracts with two doses administered there were differences compared to the control group, EAE II led to reduction of immobility time, in the FST method by 38.50% for 50 mg kg −1 to as much as 75.97% for 100 mg kg −1 . Similar results of increased antidepressant effect, that was, of immobility time depending on the concentration administered, were obtained with the TST method. However, EAE II and CE II extract at dose of 100 mg kg −1 were obtained as best to choose an antideprssant activity. However, amounts of phenolic and flavonoid groups were found in CE II extract. As a conclusion treatment using selected crude extracts of P. microphylla had an antidepressant-like effect across models. Reduced immobility and decreasing freezing were observed in FST and TST tests. Therefore, P. microphylla may be served as a potential resource for natural psychotherapeutic agent against depression. The present study clearly demonstrated that Pilea microphylla exerts an antidepressant effect in these two behavioural models. It may be due to present of flavonoids. This is consistent with the hypothesis that enhanced uptake of flavonoids groups might have antidepressant-like effects. However, further studies are still required.

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Antidepressant-like behavioral and neurochemical effects of the citrus-associated chemical apigenin

Cited by 102 publications

References 65 publications

Antidepressant-like Effects of an Aqueous Extract of Lavender (Lavandula angustifolia Mill.) in Rats

Antidepressant-like Effects of an Aqueous Extract of Lavender (Lavandula angustifolia Mill.) in Rats

Genistein Regulated Serotonergic Activity in the Hippocampus of Ovariectomized Rats under Forced Swimming Stress

Antidepressant-Like Effects of Selected Crude Extracts of Pilea microphylla in Mice Model of Depression

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