Antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice: Evidence for the involvement of the monoaminergic system

GC-MS profiling and antidepressant-like effect of the extracts of Hamelia patens in animal model

“…The compounds which able to increases locomotor activity in open field test including psychostimulants, convulsants and anticholinergics give a false positive result in tail suspension and forced swim test (Farah Idayu et al, 2011). In general, hyperkinesis also produces false positive effect in immobility time (Freitas et al, 2010). Therefore, open field test was carried out to justify false positive effects that could be associated with psychostimulants, convulsants and anticholinergics or hyperkinesis (Kwon et al, 2010).…”

NMDA Receptors and the L-Arginine–Nitric Oxide–Cyclic Guanosine Monophosphate Pathway Are Implicated in the Antidepressant-Like Action of the Ethanolic Extract fromTabebuia avellanedaein Mice

“…Further, EET produced a synergistic antidepressant-like effect when combined with conventional antidepressants. 10 Additionally, a recent study performed by our group demonstrated that the administration of EET during 14 days is able to abolish the increased immobility time in the TST in bulbectomized mice. 12 Besides the monoaminergic systems, several other targets have been implicated in the pathogenesis of depressive disorders.…”

“…24 Several studies have demonstrated that NOS inhibitors produce antidepressant-like actions in a variety of animal paradigms. 14,25 Considering that (1) NMDA receptors and the NO-cGMP pathway are involved in the pathogenesis of depression; 13,14 (2) the importance of these molecular targets for the efficacy of antidepressants; 26,27 (3) the relationship between the monoaminergic systems and the blockade of the NMDA receptors and the modulation of NO synthesis; 13,19 and (4) the antidepressant-like effect of EET in the TST was reported to be dependent on the modulation of the monoaminergic systems, 10 but its mechanisms of action still remain to be fully established; the aim of the present study was to investigate the participation of NMDA receptors and Larginine-NO-cGMP pathway in the antidepressant-like effect of EET in the TST.…”

“…23,25,28,31 The dose-response curve of EET in the TST was established in a work previously performed by our group. 10 The doses of the extract used in the present study were selected on the basis of these experiments.…”

<i>Vitis vinifera</i> juice ameliorates depression-like behavior in mice by modulating biogenic amine neurotransmitters

“…Nonetheless, these medications can cause numerous adverse drug reactions. Hence, substantial endeavors are made to discover the better medications for the therapeutic use to manage depression and other related disorders (Freitas et al, 2010).…”