Antidepressant Discontinuation Syndrome: A Common but Underappreciated Clinical Problem

Rizkalla, Mireille N.; Kowalkowski, Bryan; Prozialeck, Walter C.

doi:10.7556/jaoa.2020.030

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…Catatonia as an antidepressant withdrawal syndrome has been documented with MAOI. [ 2 ] However, it has not been reported to be associated with the withdrawal of TCAs. TCAs act by inhibiting the uptake of norepinephrine, serotonin, and dopamine, in conjunction with muscarinic anticholinergic effects.…”

Section: Discussionmentioning

confidence: 99%

Sudden onset catatonia following tricyclic antidepressant withdrawal - A case report

Sharma,

Naskar,

Sharma

et al. 2023

Indian Journal of Psychiatry

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Section: Discussionmentioning

confidence: 99%

Sudden onset catatonia following tricyclic antidepressant withdrawal - A case report

Sharma,

Naskar,

Sharma

et al. 2023

Indian Journal of Psychiatry

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“…However, individual responses to medications can vary, and in rare cases, some people may experience unusual side effects or adverse reactions. It's important to note that abrupt discontinuation of amitriptyline or any antidepressant should be avoided, as it can lead to withdrawal symptoms [35].…”

Section: Amitriptylinementioning

confidence: 99%

A Literature Review of Movement Disorder Associated with Medications and Systemic Diseases

Pitton Rissardo,

Fornari Caprara

2024

Preprint

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Movement disorders can be associated with various drugs and systemic diseases, posing diagnostic challenges for clinicians. This review explores the spectrum of movement disorders associated with pharmacological agents and medical conditions. Drug-induced movement disorders encompass a broad range of conditions resulting from exposure to medications that affect several neurotransmitters. Neuroleptic medications can lead to tardive dyskinesia, characterized by involuntary, repetitive movements. Antipsychotics and antiemetics, including metoclopramide, may induce acute dystonic reactions. Other drugs, such as dopamine receptor-blocking agents, can contribute to drug-induced parkinsonism. Beyond medications, movement disorders can also arise secondary to systemic diseases. Metabolic disorders like Wilson's disease, characterized by copper accumulation, may manifest as chorea or dystonia. Inflammatory conditions such as rheumatoid arthritis and systemic lupus erythematosus can result in secondary movement disorders due to autoimmune-mediated processes affecting the central nervous system. Movement disorders linked to drugs or systemic diseases often necessitate a thorough clinical evaluation, including detailed medication histories and comprehensive systemic assessments. Neuroimaging, laboratory investigations, and, in some cases, cerebrospinal fluid analyses and electrodiagnostic studies help in establishing accurate diagnoses. Management involves addressing the underlying cause, modifying medications, and employing symptomatic treatments.

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Antidepressant Discontinuation Syndrome: A Common but Underappreciated Clinical Problem

Cited by 2 publications

References 21 publications

Sudden onset catatonia following tricyclic antidepressant withdrawal - A case report

Sudden onset catatonia following tricyclic antidepressant withdrawal - A case report

A Literature Review of Movement Disorder Associated with Medications and Systemic Diseases

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