Antidepressant and anxiolytic effects of amentoflavone isolated from Cnestis ferruginea in mice

Ishola, Ismail O.; Chatterjee, Manavi; Tota, Santoshkumar; Tadigopulla, Narender; Adeyemi, Olufunmilayo O.; Palit, Gautam; Shukla, Rakesh

doi:10.1016/j.pbb.2012.08.017

Cited by 101 publications

(59 citation statements)

References 63 publications

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“…This decrease in duration of immobility is considered to have a good predictive value in the evaluation of potential antidepressant agents [23]. In the present study, decrease in immobility time with petroleum ether extract is not significant when compared with control in both TST and FST.…”

Section: Pendyala Et Alcontrasting

confidence: 52%

Phytochemical and Pharmacological Evaluation of Commiphora Mukul for Antidepressant Activity in Albino Mice

Pendyala¹,

Janga²,

Vidyadhara³

2016

Asian J Pharm Clin Res

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Objective: The main aim and objective of the present study is to investigate the effect of Commiphora mukul (Family: Burseraceae), on depression in mice using tail suspension test (TST) and forced swim test (FST). Methods:The oleo-gum resin of guggul was extracted with alcohol and fractionated with ethyl acetate and petroleum ether. All the fractions were subjected for preliminary phytochemical screening, using various qualitative tests. Till date, no scientific data were available on the antidepressant activity of this plant. So, in the present investigation, TST and FST are selected as animal models for evaluation of antidepressant activity in albino mice. Results:The preliminary phytochemical screening of guggul has revealed the presence of carbohydrates, proteins, tannins, and flavonoids in hydroalcoholic fraction. Ethyl acetate fraction showed positive results toward flavonoids, alkaloids, proteins, and steroids. Hydroalcoholic, ethyl acetate, and petroleum ether fractions (50 and 100 mg/kg p.o.) of guggul administered orally for 14 successive days had decreased the immobility periods significantly in a dose-dependent manner in both TST and FST, showing significant antidepressant-like activity. The activities of the fractions were found to be comparable to imipramine in both FST and TST.Conclusions: Although a number of synthetic drugs are being used as standard treatment for clinically depressed patient, they have adverse effects that can compromise the therapeutic treatment. In the traditional systems of medicine, many plants and formulations have been used to treat depression for thousands of years. The results of this study indicate the potential for the use of guggul as an adjuvant in the treatment of depression.

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Section: Pendyala Et Alcontrasting

confidence: 52%

Phytochemical and Pharmacological Evaluation of Commiphora Mukul for Antidepressant Activity in Albino Mice

Pendyala¹,

Janga²,

Vidyadhara³

2016

Asian J Pharm Clin Res

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“…Investigations are now focused on the search of novel and better tolerated molecules from natural resources to control the severity and the progression of mental disorders (Chatterjee et al, 2011b(Chatterjee et al, , 2013Ishola et al, 2012;Zhang, 2004). Natural products have characteristically high chemical diversity, biochemical specificity, and several other medicinal properties that make them favorable lead structures for the treatment for various disorders, including psychosis.…”

Section: Introductionmentioning

confidence: 99%

Antipsychotic activity of standardizedBacopaextract against ketamine-induced experimental psychosis in mice: Evidence for the involvement of dopaminergic, serotonergic, and cholinergic systems

Chatterjee

Verma

Kumari

et al. 2015

Pharmaceutical Biology

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(2015) Antipsychotic activity of standardized Bacopa extract against ketamine-induced experimental psychosis in mice: Evidence for the involvement of dopaminergic, serotonergic, and cholinergic systems, Pharmaceutical Biology, 53:12, 1850-1860, DOI: 10.3109/13880209.2014 (40, 80, and 120 mg/kg, p.o.) were given to the mice 1 h prior to ketamine administration and tested for positive symptoms and cognitive deficits. A chronic ketamine treatment regimen was used to study the effect of BM on negative symptoms such as immobility enhancement. Each mouse was used once for the behavioral studies.Results: BM reduced ketamine-induced hyperactivity with an EC 50 value of 76.60 mg/kg. The 80 mg/kg dose was used for all other behavior analysis. Pretreatment with BM at 80 mg/kg showed two-fold increases in transfer latency time (TLT) in passive avoidance task. Chronic BM pretreatment (80 mg/kg p.o. daily Â 10 d) ameliorated the ketamine-induced enhanced immobility effect by 21% in the forced swim test. BM treatment reversed ketamine-induced increase in monoamine oxidase activity in both cortex and striatum and normalized the acetylcholinesterase activity and the glutamate levels in the hippocampus. Discussion and conclusion: Overall our findings suggest that BM possesses antipsychotic properties which might be due to its modulatory action on dopamine, serotonin, and glutamate neurotransmission.

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“…or sulpiride (50 mg/kg, i.p.) (Gu et al, 2012;Ishola et al, 2012Ishola et al, , 2014, 15 min before oral administration of the effective doses of ecdysteroids. All were administered at 10 ml/kg/body weight of each animal.…”

Section: Chemicals and Drugs Treatment Regimenmentioning

confidence: 99%

“…The vehicle-treated control group received DMSO (0.05%v/v in normal saline) and conventional antidepressants (imipramine and fluoxetine (20 mg/kg, p.o.)) served reference standards (Ishola et al, 2012). For each of the treatment groups with the exception of open field test (where, n = 6), 8 mice per group were used.…”

Section: Chemicals and Drugs Treatment Regimenmentioning

confidence: 99%

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Potential of novel phytoecdysteroids isolated from Vitex doniana in the treatment depression: Involvement of monoaminergic systems

Ishola

Ochieng

Olayemi

et al. 2014

Pharmacology Biochemistry and Behavior

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Antidepressant and anxiolytic effects of amentoflavone isolated from Cnestis ferruginea in mice

Cited by 101 publications

References 63 publications

Phytochemical and Pharmacological Evaluation of Commiphora Mukul for Antidepressant Activity in Albino Mice

Phytochemical and Pharmacological Evaluation of Commiphora Mukul for Antidepressant Activity in Albino Mice

Antipsychotic activity of standardizedBacopaextract against ketamine-induced experimental psychosis in mice: Evidence for the involvement of dopaminergic, serotonergic, and cholinergic systems

Potential of novel phytoecdysteroids isolated from Vitex doniana in the treatment depression: Involvement of monoaminergic systems

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