Potential of novel phytoecdysteroids isolated from Vitex doniana in the treatment depression: Involvement of monoaminergic systems

Ishola, Ismail O.; Ochieng, Charles O.; Olayemi, SO; Jimoh, Memunat O.; Lawal, Saheed M.

doi:10.1016/j.pbb.2014.11.005

Cited by 16 publications

(6 citation statements)

References 38 publications

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“…The practical uses of ecdysteroids (including humans) have been critically reviewed by Lafont and Dinan [6]. Nevertheless, only a few publications have been dealing with any interaction of ecdysteroids and the central nervous system [7,8]. Lipophilic substituents on hydroxyl(s) are supposed to change both their hydrophilic/hydrophobic character and their distribution in the mammalian central nervous system.…”

Section: Introductionmentioning

confidence: 99%

HPLC analysis and blood-brain penetration of 20-hydroxyecdysone diacetonide

Kalász

Hunyadi

Tekes

et al. 2017

Acta Chromatographica

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Summary. Blood-brain penetration of 20-hydroxyecdysone 2,3;20,22-diacetonide (20DA) has been scouted using chromatographic methods. In vivo experiments were performed by treating male Wistar rats intraperitoneally (i.p.) with a dose of 50 mg kg −1 20DA. Control experiment was done by using 20-hydroxyecdysone (20E). Definite brain penetration of 20DA was found by using high-performance liquid chromatography (HPLC), while 20E does not show this type of distribution.

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Section: Introductionmentioning

confidence: 99%

HPLC analysis and blood-brain penetration of 20-hydroxyecdysone diacetonide

Kalász

Hunyadi

Tekes

et al. 2017

Acta Chromatographica

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“…The specific mechanism of anti-inflammation has not been explored scientifically, but if it is revealed that COX-2 inhibition occurs, then this may help to explain the application to treat malaria. Furthermore, ecdysteroids from V. doniana are involved in modulation of the monoaminergic systems of the brain [ 23 ]. While this conveys the link to the use of V. doniana in the treatment of depression, the monoaminergic system controls thermoregulation and fever modulation as demonstrated in earlier studies via the same pathways (serotonin and dopamine) [ 24 ] as those allegedly targeted by the ecdysteroids of Vitex [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

Ecdysteroids from the Stem Bark of Vitex doniana Sweet (Lamiaceae; ex. Verbenaceae): A Geographically Variable African Medicinal Species

et al. 2021

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Vitex doniana Sweet is an African medicinal species that is prescribed as an aqueous bark extract to be applied topically or orally to achieve anti-infective outcomes. In select regions it is also taken orally as an antimalarial agent. The aim of the current study was to explore the biological properties of V. doniana and isolated compounds in the context of pathogenic bacteria and the protozoan parasite Plasmodium falciparum. Three compounds were isolated and assigned by nuclear magnetic resonance spectroscopy as ecdysteroids: (1) 20-hydroxyecdysone, (2) turkesterone, and (3) ajugasterone C. Interestingly, two of these compounds had not previously been identified in V. doniana, providing evidence of chemical variability between regions. The bark extract and three ecdysteroids were screened for activity against a panel of pathogenic bacteria associated with skin, stomach and urinary tract infections, and the protozoan parasite P. falciparum. The crude extract of the bark inhibited all bacterial strains with MIC values of 125–250 μg.mL−1. The three isolated compounds demonstrated less activity with MIC values of 500–1000 μg.mL−1. Furthermore, no activity was observed against P. falciparum at the screening concentration of 4.8 μg.mL−1. Nevertheless, we present a hypothesis for the possible mechanism for symptomatic relief of malarial fever, which may involve reduction of prostaglandin E(1) & E(2) activity in the hypothalamus via modulation of the monoaminergic system. While further studies are required to identify all antimicrobial agents within this plant species and to determine the cytotoxicity of each of these compounds, these data suggest that the traditional application of this species as an antiseptic is valid.

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“…To assess the possible effects of the extract on locomotor and exploratory behaviors, mice were individually evaluated in the open field paradigm. [940] The apparatus consisted of a wooden box measuring 40 cm × 40 cm × 30 cm, with the floor divided into 25 equal squares (8 cm × 8 cm). The number of squares crossed with all paws (crossings) and of standing on the hind legs (rearing) was observed for 5 min after 1 min acclimatization in each session.…”

Section: Methodsmentioning

confidence: 99%

“…[78] However, the combination of SSRIs with tricyclic antidepressants (TCAs) has been reported to show the drug–drug interactions and undesirable side effects, which may limit the use of the most preferred TCA–SSRI combination. [9] Hence, there is a necessity to develop the newer antidepressant drugs with more safety and efficacy. Medicinal plants could be considered an excellent source for the antidepressant novel drug discovery by virtue of its proven safety and presence of multiple phytoconstituents which may exert synergistic effects.…”

Section: Introductionmentioning

confidence: 99%

Antidepressant-like effect of a standardized hydroethanolic extract of Asparagus adscendens in mice

Pahwa

Goel

2019

Indian J Pharmacol

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OBJECTIVE: Asparagus adscendens Roxb. (Liliaceae), a traditional herbal medicine, has been used as an aphrodisiac and brain tonic in Asian countries. The aim of the present study is to investigate the antidepressant-like effect of standardized hydroethanolic extract of A. adscendens root and its possible mechanisms. MATERIALS AND METHODS: Mice administered with vehicle, imipramine (15 mg/kg/day; i.p.), and A. adscendens extract (AAE) (25, 50, and 100 mg/kg/day; i.p.) for 14 days were subjected to behavioral tests including forced swimming test (FST), tail suspension test (TST), and open-field test (OFT) on the 14 th day. In order to explore the underlying mechanism behind an antidepressant effect of AAE, the brain monoamine levels, oxidative stress parameters, and serum corticosterone levels were monitored. RESULTS: Our results indicated that pretreatment of AAE (25, 50, and 100 mg/kg) for 14 days statistically significantly ( P < 0.01) demonstrated antidepressant-like effect as evidenced by reduced immobility time in both FST (105, 78.6, and 53.6 s) and TST (97.6, 73.5, and 54.67 s), with no significant change in spontaneous locomotor activities as observed in OFT. Further, the behavioral improvement was supported by the statistically significantly ( P < 0.05) enhanced levels of monoamines and reduced corticosterone level along with amelioration of oxidative stress in AAE-treated animals as compared to vehicle control group. Conclusion: Our findings clearly demonstrated the antidepressant-like effect of AAE, which might have been mediated through the modulation of monoaminergic system and by regulating hypothalamic–pituitary–adrenal axis with amelioration of oxidative stress.

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Potential of novel phytoecdysteroids isolated from Vitex doniana in the treatment depression: Involvement of monoaminergic systems

Cited by 16 publications

References 38 publications

HPLC analysis and blood-brain penetration of 20-hydroxyecdysone diacetonide

HPLC analysis and blood-brain penetration of 20-hydroxyecdysone diacetonide

Ecdysteroids from the Stem Bark of Vitex doniana Sweet (Lamiaceae; ex. Verbenaceae): A Geographically Variable African Medicinal Species

Antidepressant-like effect of a standardized hydroethanolic extract of Asparagus adscendens in mice

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