Anticonvulsants

Toman, James E. P.; Goodman, Louis S.

doi:10.1152/physrev.1948.28.4.409

Cited by 57 publications

(16 citation statements)

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“…PTZ results in first a clonic phase and then a tonic phase (i.e., clonic-tonic seizures), whereas MES results in tonic-clonic seizures, 37 that is, the tonic phase precedes the clonic phase. This work further confirmed that phenytoin does not raise seizure threshold, but rather prevents seizure spread, 38 setting the stage for ASD differentiation studies for decades. 15 Moreover, the subcutaneous (s.c.) PTZ test has been validated clinically with the identification of ethosuximide (and trimethadione) for absence seizures.…”

Section: Stimulation Protocolsupporting

confidence: 66%

A companion to the preclinical common data elements for pharmacologic studies in animal models of seizures and epilepsy. A Report of the TASK3 Pharmacology Working Group of the ILAE/AES Joint Translational Task Force

et al. 2018

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SummaryPreclinical pharmacology studies in animal models of seizures and epilepsy have provided a platform to identify more than 20 antiseizure drugs in recent decades. To minimize variability in lab‐to‐lab studies and to harmonize approaches to data collection and reporting methodology in pharmacologic evaluations of the next generation of therapies, we present common data elements (CDEs), case report forms (CRFs), and this companion manuscript to help with the implementation of methods for studies in established preclinical seizure and epilepsy models in adult rodents. The development of and advocacy for CDEs in preclinical research has been encouraged previously by both clinical and preclinical groups. It is anticipated that adoption and implementation of these CDEs in preclinical studies may help standardize approaches to minimize variability and increase the reproducibility of preclinical studies. Moreover, they may provide a methodologic framework for pharmacology studies in atypical animal models or models in development, which may ultimately promote novel therapy development. In the present document, we refer selectively to animal models that have a long history of preclinical use, and in some cases, are clinically validated.

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Section: Stimulation Protocolsupporting

confidence: 66%

A companion to the preclinical common data elements for pharmacologic studies in animal models of seizures and epilepsy. A Report of the TASK3 Pharmacology Working Group of the ILAE/AES Joint Translational Task Force

et al. 2018

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“…The reverse is also true, and these compounds are therefore a valuable complementary pair (101). The structural factors important for anticonvulsant activity in 2 , 4-oxazolidinediones and other classes of antiepileptic agents have been discussed (167,168),…”

Section: Cehs Chmentioning

confidence: 99%

2,4-Oxazolidinediones

Clark-Lewis¹

1958

Chem. Rev.

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“…In this study, for the screening of aqueous extract of Centella asiatica for anticonvulsant activity, two standard methods namely MES and PTZ methods had been used [16]. The parameters observed were the duration of tonic hind limb flexion, tonic hind limb extension, clonus, post-ictal depression and incidence of recovery and death.…”

Section: The Design Of the Study Is As Followsmentioning

confidence: 99%

Evaluation of the Anticonvulsant Effect of Aqueous Extract of Centella Asiatica in Albino Mice

Deka

Chakravarty

Purkayastha

2017

Int J Pharm Pharm Sci

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Objective: To evaluate the antiepileptic activity of aqueous extract of Centella asciatica in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced convulsions. Methods:The anticonvulsant activity of leaves of Centella asciatica (200 mg/kg and 400 mg/kg) in mice was assessed using MES and PTZ induced seizure models. Abolition of tonic hind limb extension (MES and PTZ) and increase in seizure latency (PTZ) when compared to control group, were taken as a measure of protection. Statistical analysis was done using one-way ANOVA followed by Tukey-Kramer multiple comparisons test. The test was considered to be significant at p<0.05. Results:The aqueous extract of Centella asiatica at a dose of 200 mg/kg has abolished tonic hind limb extension in 1 out of 6 animals in MES while there was no anticonvulsant action in PTZ convulsions. At a dose of 400 mg/kg body weight, the aqueous extract of Centella asiatica has shown a significant anticonvulsant effect against both MES and PTZ convulsions, where it has abolished tonic hind limb extension in 4 mice in MES method and in all 6 mices in PTZ method. Conclusion:The aqueous extract of Centella asiatica showed efficacy in both MES and PTZ convulsions in mice at a dose of 400 mg/kg. Since the clinical correlates of MES seizures are tonic-clonic convulsions and correlates of PTZ seizures are absence seizures, the aqueous extract of Centella asiatica is likely to be useful in the treatment of tonic-clonic and absence seizures.

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Anticonvulsants

Cited by 57 publications

References 0 publications

A companion to the preclinical common data elements for pharmacologic studies in animal models of seizures and epilepsy. A Report of the TASK3 Pharmacology Working Group of the ILAE/AES Joint Translational Task Force

A companion to the preclinical common data elements for pharmacologic studies in animal models of seizures and epilepsy. A Report of the TASK3 Pharmacology Working Group of the ILAE/AES Joint Translational Task Force

2,4-Oxazolidinediones

Evaluation of the Anticonvulsant Effect of Aqueous Extract of Centella Asiatica in Albino Mice

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