Anticonvulsant properties of γ-decanolactone in mice

Souza, Gabriela Peixoto Coelho de; Elisabetsky, Elaine; Nunes, Domingos Sávio; Rabelo, S.K.L.; Silva, Milton

doi:10.1016/s0378-8741(97)00102-5

Cited by 23 publications

(15 citation statements)

References 11 publications

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“…Previous work reported that gamma-decanolactone has marked dosedependent effects on the central nervous system, including anticonvulsant activity (Coelho de Souza et al, 1997). In an in vitro study we showed that gamma-decanolactone is a noncompetitive glutamate antagonist (Pereira et al, 1997).…”

Section: Discussionmentioning

confidence: 57%

“…1) is a monoterpene compound, structurally related to lactones that are present in the essential oil of Aeollanthus suaveolens (used by Amazonian caboclos as a remedy), and it was shown to be active in some animal models (Elisabetsky et al, 1995;Coelho de Souza et al, 1997). Some gamma-decanolactone biological activities were described.…”

Section: Introductionmentioning

confidence: 99%

“…The psychopharmacological evaluation of this compound in mice revealed that it has a dose-dependent effect on central nervous system (CNS), including hypnotic, anticonvulsant, and hypothermic activities; a single administration of gamma-decanolactone (i.p.) was effective in preventing acute pentylenetetrazol (PTZ)-induced convulsions (Coelho de Souza et al, 1997). The mechanisms involved in these behavioral effects are not clear yet.…”

Section: Introductionmentioning

confidence: 99%

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Gamma-decanolactone effect on behavioral and genotoxic parameters

et al. 2007

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Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gamma-decanolactone effect on behavioral and genotoxic parameters

et al. 2007

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“…A study conducted on mice with the essential oil of A. suaveolens has reported dose-dependent marked effects on the central nervous system and anticonvulsant effect [11]. Another study with the flowers and leaves of the plant have showed a significant content of monoterpenes, which was then concluded to be reason for anticonvulsant and sedative properties.…”

Section: A Suaveolensmentioning

confidence: 99%

Anticonvulsant Properties of Some Medicinal Plants- A Review

Srinivasan¹,

Anitha²

2017

Asian J Pharm Clin Res

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Introduction: Epilepsy is the tendency to have seizures that start in the brain. The brain uses electrical signals to pass messages between brain cells and when these signals are disrupted, it leads to a seizure. A number of synthetic antiepileptic drugs are available in practice, but various medicinal plants act as an important source of treatment for epilepsy; plants such as Aeollanthus suaveolens, Passiflora caerulea, Persea americana, Annona diversifolia, and Boerhavia diffusa have good anticonvulsant activity.

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“…g-Decalactone, for example, has a peachlike odor and it is used industrially, as a ''natural'' aroma compound when it is produced through biotechnological processes by yeast cells . This compound has also recently been described for anticonvulsant properties (Coelho de Souza et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Interaction of an odorant lactone with model phospholipid bilayers and its strong fluidizing action in yeast membrane

Aguedo

Beney

Waché

et al. 2003

International Journal of Food Microbiology

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Some odorant lactones are naturally present in fruits or in fermented products; they can also be used as food additives and can be produced by microorganisms at the industrial scale by biotechnological processes. g-Decalactone was previously shown to have antimicrobial properties. We determined by infrared spectroscopy measurements that this compound rapidly diffused into model phospholipid bilayers (within 2 min), modifying the general physical state of a dimyristoyl-L-a-phosphatidylcholine (DMPC) film. In vivo, the lactone strongly increased membrane fluidity in the model yeast Yarrowia lipolytica, as evaluated by fluorescence anisotropy measurements. This effect was more important than that of benzyl alcohol, which is known as a fluidizing agent in living cells, and may explain the toxic action of g-decalactone in microorganisms. D

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Anticonvulsant properties of γ-decanolactone in mice

Cited by 23 publications

References 11 publications

Gamma-decanolactone effect on behavioral and genotoxic parameters

Gamma-decanolactone effect on behavioral and genotoxic parameters

Anticonvulsant Properties of Some Medicinal Plants- A Review

Interaction of an odorant lactone with model phospholipid bilayers and its strong fluidizing action in yeast membrane

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