Anticonvulsant and sedative effects of paederosidic acid isolated from Paederia scandens (Lour.) Merrill. in mice and rats

Yang, Tao; Kong, Bin; Gu, Jianwen; Kuang, Yongqin; Cheng, Lin; Yang, Wentao; Cheng, Jingmin; Ma, Yi; Yang, Xiaokun

doi:10.1016/j.pbb.2013.08.015

Cited by 31 publications

(32 citation statements)

References 13 publications

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“…In addition, we made an attempt to support mitochondria-mediated intrinsic apoptosis as one of the major apoptotic pathways in SGC-7901 cells. Apoptosis is a cell-intrinsic programmed suicide mechanism for damaged cells and mitochondriamediated intrinsic apoptosis is one of the major apoptotic pathways of apoptosis [8,11]. Caspase proteins play pivotal roles in initiation and execution of apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…The identification of PA (Fig 1) was accomplished by spectroscopic methods (MS, 1 H NMR and 13 C NMR) and the spectral data of PA are corresponding to literature values [8,10]. PA was purified with purity not less than 98 % (HPLC assay).…”

Section: Identification Of the Compound Isolated From P Scandensmentioning

confidence: 99%

“…Merrill, known as "Ji Shi Teng" in Chinese, is a climbing plant belonging to the family Rubiaceae [8]. It is widely distributed in China, India, Vietnam, Japan, the Philippines, and the USA.…”

Section: Introductionmentioning

confidence: 99%

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In vitro Anti-Gastric Tumor Activities and Possible Mechanisms of Action of Paederosidic Acid from Paederia scandens (Lour) Merrill

Chen¹,

Zeng²,

Zhuang³

2015

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 99%

Section: Identification Of the Compound Isolated From P Scandensmentioning

confidence: 99%

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In vitro Anti-Gastric Tumor Activities and Possible Mechanisms of Action of Paederosidic Acid from Paederia scandens (Lour) Merrill

Chen¹,

Zeng²,

Zhuang³

2015

Trop. J. Pharm Res

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“…was administered once a day for 4 weeks. Criteria for establishing the chronic epileptic model by PTZ kindling were ''strong jerking and jumping, and shouting'' (Yang et al 2013). The chronic epileptic rats were pretreated with normal saline (20 mL/kg, i.g.)…”

Section: Chronic Epileptic Rat Seizures Induced By Ptz and Western Blmentioning

confidence: 99%

Antiepileptic activity of total triterpenes isolated fromPoria cocosis mediated by suppression of aspartic and glutamic acids in the brain

Gao

Yan

Jin³

et al. 2016

Pharmaceutical Biology

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Context: Triterpenes from Poria cocos Wolf (Polyporaceae) have been used to treat various diseases in traditional Chinese medicine. However, the antiepileptic effects and mechanism are not fully understood. Objective: The objective of this study is to investigate the antiepileptic properties of total triterpenes (TTP) from the whole P. cocos. Materials and methods: The ethanol extract TTP was identified by HPLC fingerprint analysis. Male ICR mice were gavaged (i.g.) with TTP (5, 20, 80 or 160 mg/kg) or reference drugs twice a day for 7 d. Antiepileptic activities of TTP were evaluated by maximal electroshock (MES)-and pentylenetetrazole (PTZ)-induced seizures in mice for 30 and 60 min, respectively. Locomotor activity and Rota-rod tests were performed for 60 min and 5 min, respectively. The levels of glutamic acid (Glu), aspartic acid (Asp), c-aminobutyric acid (GABA) and glycine (Gly) in convulsive mice were estimated. The chronic epileptic model of Wistar rats was built to measure expressions of glutamate decarboxylase 65 (GAD65) and GABA A in rat brain after TTP treatment. Results: The LC 50 of TTP (i.g.) was above 6 g/kg. TTP (5-160 mg/kg) protected mice against MES-and PTZinduced convulsions at 65.0% and 62.5%, respectively, but have no effect on rota-rod treadmill; TTP (20-160 mg/kg) significantly reduced the locomotor activities, shortened the onset of pentobarbital sodium-induced sleep; TTP decreased Glu and Asp levels in convulsive mice, but increased the GAD65 and GABA A expressions in chronic epileptic rats at doses usage. Discussion and conclusion: TTP extracted from P. cocos possessed potential antiepileptic properties and is a candidate for further antiepileptic drug development. ARTICLE HISTORY

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“…The chronic epileptic rat model was established using a modified method of Yang et al [13]. The rats were divided into 4 groups: control group and three treatment groups of FCP (50, 100 and 200 mg/kg).…”

Section: Ptz Induced Chronic Epileptic Ratsmentioning

confidence: 99%

Anticonvulsant and sedative effect of Fufang Changniu pills and probable mechanism of action in mice

Zhang¹,

Lu²,

Zhang³

et al. 2016

Trop. J. Pharm Res

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Anticonvulsant and sedative effects of paederosidic acid isolated from Paederia scandens (Lour.) Merrill. in mice and rats

Cited by 31 publications

References 13 publications

<i>In vitro</i> Anti-Gastric Tumor Activities and Possible Mechanisms of Action of Paederosidic Acid from <i>Paederia scandens</i> (Lour) Merrill

<i>In vitro</i> Anti-Gastric Tumor Activities and Possible Mechanisms of Action of Paederosidic Acid from <i>Paederia scandens</i> (Lour) Merrill

Antiepileptic activity of total triterpenes isolated fromPoria cocosis mediated by suppression of aspartic and glutamic acids in the brain

Anticonvulsant and sedative effect of <i>Fufang Changniu</i> pills and probable mechanism of action in mice

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