&lt;i&gt;In vitro&lt;/i&gt; Anti-Gastric Tumor Activities and Possible Mechanisms of Action of Paederosidic Acid from &lt;i&gt;Paederia scandens&lt;/i&gt; (Lour) Merrill

Chen, Lilin; Zeng, Ru; Zhuang, Yanzhen

doi:10.4314/tjpr.v14i5.8

Cited by 5 publications

(4 citation statements)

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“…They have been studied for their anti-cancer and anti-microbial activities. For example, oleanolic acid and ursolic acid, both triterpenoids, are recognized for their ability to induce apoptosis in cancer cells and inhibit the growth of bacteria and fungi, thus showcasing the plant's potential as a source for anti-infective and anticancer agents [9,10] .…”

Section: Triterpenoidsmentioning

confidence: 99%

“…Paederia scandens exhibits both gastroprotective and antioxidant properties, making it a promising candidate for natural remedies and preventive measures against various diseases. Its gastroprotective effects make it a potential treatment against ulcers and other gastrointestinal disorders, with flavonoids and triterpenoids found in the plant contributing to its ability to strengthen mucosal defenses and inhibit harmful gastric secretions [1,10] . Additionally, the antioxidant properties of Paederia scandens, attributed to flavonoids and other antioxidant compounds, could be harnessed in preventing oxidative stress-related diseases, including cardiovascular diseases and neurodegenerative disorders [3,8,27].…”

Section: Gastroprotective and Antioxidant Potentialmentioning

confidence: 99%

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Advances in the Chemical Components and Pharmacological Effects of Paederia Scandens

2024

medcm

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Paederia scandens (L.) Merr., commonly known as 'ji shi teng' in traditional Chinese medicine, has garnered attention for its medicinal benefits. This review synthesizes the research on its chemical constituents-iridoids, flavonoids, triterpenoids, and essential oils-and their pharmacological effects, including anti-inflammatory, analgesic, gastroprotective, and antioxidant activities. Despite promising pharmacological profiles, the clinical applications of this herb are still limited, highlighting the need for further clinical trials and pharmacokinetic studies. This paper emphasizes the integration of traditional herbal medicine with modern research to fully explore the therapeutic potential of Paederia scandens.

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Section: Triterpenoidsmentioning

confidence: 99%

Section: Gastroprotective and Antioxidant Potentialmentioning

confidence: 99%

Advances in the Chemical Components and Pharmacological Effects of Paederia Scandens

2024

medcm

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“…MTT assay, according to previous report, was carried out to evaluate the viability of cancer 5637 cells [10]. Cells were seeded into a 96-well plate at 1 × 10 5 cells/mL, which were then exposed to wogonoside at different concentrations of 0 (control), 2, 4, 8, 16, 32, 64, and 128 μM for another 24 h. The microplate reader (Bio-rad, CA, USA) was employed to measure the absorbance at 570 nm, and the IC 50 value of wogonoside against 5637 cells was calculated.…”

Section: Cell Viability Assaymentioning

confidence: 99%

Wogonoside exerts potential anti-tumor activity against bladder cancer in vivo and in vitro via regulation of GSK3β/ERK/AKT signaling pathway

Jiexiang¹,

Cao²,

Li³

et al. 2021

Trop. J. Pharm Res

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Purpose: To explore the antitumor activity of wogonoside on bladder cancer, and its underlying mechanism of action. Methods: Methyl thiazolyl tetrazolium (MTT) assay was applied to determine the anti-proliferative activity of wogonoside (2 - 128 μM) on bladder cancer 5637 cell line at various times, and the halfmaximal inhibitory concentration (IC50) was measured. The antitumor activity of wogonoside (30 mg/kg, ip) against bladder cancer 5637 cell line was evaluated in nude mice bearing human bladder cancer 5637 cells. Additionally, western blotting and enzyme-linked immunosorbent assay (ELISA) were carried out to investigate the levels of the caspase-3, caspase-9, B cell lymphoma/leukemia-2 (Bcl-2), Bcl-2 associated X-protein (Bax), phosphorylated (p)-glycogen synthase kinase (GSK)-3β, p-extracellular signal-regulated kinases (p-ERK), and p-(protein kinase B) AKT. Results: The in vitro results revealed that wogonoside exerted anti-proliferative activity against bladder cancer 5637 cells with an IC50 of 20.59 μM (p < 0.01), in a concentration- and time-dependent manner. Furthermore, wogonoside treatment also significantly suppressed tumor volume in mice (p < 0.01). The potential mechanisms were mainly associated with apoptosis mediated by mitochondria via upregulation of caspase-3, caspase-9, and Bax levels and down-regulation of Bcl-2, p-GSK-3β, p-ERK, and p-AKT. Conclusion: The results reveal that wogonoside has remarkable anti-tumor potentials against bladder cancer. Further translational studies are warranted to test the clinical application of this medicinal agent in bladder cancer.

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“…Increasingly, previous studies have revealed that chemotherapy using natural agents with low toxicity is a promising approach for treating various types of cancer (8)(9)(10). In addition, traditional Chinese medicine (TCM) has been used in the treatment of various incurable diseases for centuries, and the reliability and effectiveness of TCMs have been demonstrated by long-term clinical use in China (11,12).…”

Section: Introductionmentioning

confidence: 99%

Riparsaponin isolated from Homonoia?riparia Lour induces apoptosis of oral cancer cells

Wang

2017

Oncol Lett

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Abstract. Homonoia riparia Lour (Euphorbiaceae) is a known source of herbal medicine in China, and riparsaponin (RSP) is an active constituent isolated from H. riparia. The aim of the present study was to investigate the antitumor effect of RSP on human oral carcinoma cells and its potential underlying molecular mechanism. RSP was isolated from roots of H. riparia and identified using nuclear magnetic resonance. An MTT assay was used to evaluate the cytotoxicity of RSP on human oral carcinoma cells. Subsequently, DAPI staining was performed to investigate the apoptotic effect of RSP. To investigate the potential underlying molecular mechanism of action of RSP, western blotting was performed to determine the expression of cleaved caspase 3/9, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), Bcl-2-associated death promoter (Bad), epithelial cadherin (E-CAD), c-MET, matrix metalloproteinase (MMP)-2 and MMP-9. RSP exhibited a significant anti-proliferative effect on oral carcinoma cells at concentrations between 10 and 200 µg/ml via apoptosis. Following treatment with RSP (20, 40 and 80 µg/ml), expression of cleaved caspase-3 (P<0.05, P<0.01 and P<0.01, respectively), cleaved caspase-9 (P<0.01), Bad (P<0.01), Bax (P<0.01), c-MET (P<0.01), MMP-2 (P<0.01) and MMP-9 (P<0.01) in oral carcinoma cells was increased significantly compared with the control group, whereas expression of Bcl-2 (P<0.01) and E-CAD (P<0.01) was decreased. These results suggest that RSP possessed notable antitumor activity against oral squamous cell carcinoma by inducing mitochondria-mediated apoptosis. IntroductionIt is reported that oral squamous cell carcinoma (OSCC), one of the most common oral malignancies of the squamous epithelium of the oral cavity, is the sixth most common type of cancer globally (1-3). It has been reported that developing countries have the highest incidence rates of OSCC and it is expected that the incidence will continue to increase (4); furthermore, OSCC commonly occurs in middle-aged and elderly males because of tobacco and alcohol use (5). OSCC commonly occurs in the tissues of the oral cavity, including the gingiva, tongue, lip, hard palate, buccal mucosa and mouth floor (4,6). OSCC exhibits a marked propensity for invasive growth and metastasis, leading to damage of the original tissues or that of distant organs (2,4). The predominant treatment strategy for OSCC is radical surgery and postoperative chemoradiation (4). Marked improvements have been made in clinical diagnosis and management of OSCC; however, high recurrence rates and low 5-year survival rates have remained constant for several decades (7).Increasingly, previous studies have revealed that chemotherapy using natural agents with low toxicity is a promising approach for treating various types of cancer (8-10). In addition, traditional Chinese medicine (TCM) has been used in the treatment of various incurable diseases for centuries, and the reliability and effectiveness of TCMs have been demonstrated by long-term clinical use in China (11,12)...

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<i>In vitro</i> Anti-Gastric Tumor Activities and Possible Mechanisms of Action of Paederosidic Acid from <i>Paederia scandens</i> (Lour) Merrill

Cited by 5 publications

References 16 publications

Advances in the Chemical Components and Pharmacological Effects of Paederia Scandens

Advances in the Chemical Components and Pharmacological Effects of Paederia Scandens

Wogonoside exerts potential anti-tumor activity against bladder cancer in vivo and in vitro via regulation of GSK3β/ERK/AKT signaling pathway

Riparsaponin isolated from Homonoia?riparia Lour induces apoptosis of oral cancer cells

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