Anticonvulsant activity of furanocoumarins and the essential oil obtained from the fruits of Heracleum crenatifolium

Chemical composition, antibacterial and antifungal activities of essential oil from Heracleum Siamicum Craib

“…Brummitt [15], H. crenatifolium Boiss. [16,17], H. platytaenium Boiss. [16], and H. candolleanum [18].…”

“…ex Fisher showed antibacterial activity that inhibited the growth of Staphylococcus aureus, Bacillus cereus, and Bordetella bronchiseptica [19]. Different octyl esters, especially n-octyl acetate, were reported to be the major constitute in most of the oils investigated [12,16,20,21].…”

Analytical Methods for Isolation, Separation and Identification of Selected Furanocoumarins in Plant Material

“…The furanocoumarin determination from air-dried plant material was also performed using 75% methanol in an ultrasonic ice-water bath , with 100% methanol (Cardoso et al, 2000;Ojala, 2000), 70% methanol (Chen & Sheu, 1995), with hot (70˚C) pure methanol on a water bath (Bartnik & Głowniak, 2007), with pure ethanol in heated reflux (Yu et al, 2002), with 95% ethanol at 80˚C Zheng et al, 2010), with acetone at room temperature (Taniguchi et al, 2011), with ether at 40˚C (Liu et al, 2004a), with dichloromethane at room temperature (Um et al, 2010), with petroleum ether at room temperature (Tosun et al, 2008), with chloroform in a sonic bath (Cardoso et al, 2000).…”

“…9-hydroxy-4-methoxypsoralen inhibited DPPH formation by 50% at a concentration of 6.1 µg/ml (IC 50 ), and alloisoimperatorin 9.4 µg/ml, thus the other nine furanocoumarins (oxypeucedanin hydrate, byakangelicol, pabulenol, neobyakangelicol, byakangelicin, oxypeucedanin, imperatorin, phellotorin, and isoimperatorin), with an IC 50 values higher than 200 µg/ml, showed only a little DPPH radical-scavenging activities. Tosun et al (2008) evaluated the anticonvulsant activity of the furanocoumarins among others compounds, obtained from the fruits of Heracleum crenatifolium. This activity was estimated against maximal electroshock seizures induced in mice.…”

“…After chromatography with the use of n-hexane-ethyl acetate (3:1), isobergapten and pimpinellin were obtained. Fractions, which were chromatographed with n-hexane-dichloromethaneethyl acetate (4:4:2) resulted in a production of bergapten, and fractions, after chromatography using toluene-ethyl acetate (9: 1 ) , r e s u l t e d i n a p r o d u c t i o n o f y i e l d e d isopimpinellin, sphondin and byak-angelicol (Tosun et al, 2008).…”