Anticonvulsant activity of Cotyledon orbiculata L. (Crassulaceae) leaf extract in mice

Antidiarrhoeal activity of Geranium incanum Burm. f. (Geraniaceae) leaf aqueous extract in mice

“…The method previously described by Amabeoku et al (2007) was used. 1 kg of leaves of the plant species was washed with distilled water and dried at 35 • C for 4 days.…”

Evaluation of anticonvulsant activity of ethanolic leaves extract of Desmodium triflorum in mice

“…GABA is a major inhibitory neurotransmitter in the brain, and the inhibition of its neurotransmission has been thought to be the underlying factor in epilepsy (Silambujanaki et al, 2010). The enhancement of the GABAergic neurotransmission is reported to antagonize seizures, while the inhibition of the neurotransmission promotes seizures (Amabeokua et al, 2007). The protection of mice against PTZ-induced seizures by the standard anticonvulsant drugs, phenobarbitone and diazepam is expected, since various authors have shown that they exert their anticonvulsant activities by enhancing (compared with control group) *p<0.05, **p<0.01 and ***p<0.001.…”

Alterations in brain amino acid metabolism and inhibitory effects on PKC are possibly correlated with anticonvulsant effects of the isomeric mixture ofα- andβ-amyrin fromProtium heptaphyllum

“…Mice treated with AMY, at the dose of 25 mg/kg, had concentrations of the known excitatory amino acid neurotransmitters (Chen et al, 2005), glutamate and aspartate, inhibited very expressively, as compared with the Control group. In another study, extracts from Cotyledon orbiculata L. (Crassulaceae), a medicinal species with triterpenes among its bioactive components, presented anticonvulsant properties, probably affecting both the GABAergic and glutamatergic mechanisms (Amabeoku et al, 2007). All these data suggest that AMY may also cause changes in the modulation of these excitatory amino acids.…”