Antidiarrhoeal activity of Geranium incanum Burm. f. (Geraniaceae) leaf aqueous extract in mice

Amabeoku, G.J.

doi:10.1016/j.jep.2009.02.015

Cited by 32 publications

(22 citation statements)

References 9 publications

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“…Among these, tannins, widely distributed in nature and present in almost all plant foods and some beverages, are the major active compounds of rhubarb; moreover, they are often the active compounds of the other medicinal plants in which they occur [30, 31]. It is demonstrated that the antidiarrhoeal activity of many medicinal plants which are rich in tannins is related to the existence of tannins [2, 32]. In particular, the purgative activity of rhubarb extract could be significantly increased by reducing the content of tannins [33], and some processed products from crude rhubarb with decrease of purgative anthraquinones and relative increase of tannins even exhibited an antidiarrhoeal activity [34].…”

Section: Introductionmentioning

confidence: 99%

Rhubarb Tannins Extract Inhibits the Expression of Aquaporins 2 and 3 in Magnesium Sulphate-Induced Diarrhoea Model

Zheng

Wang

et al. 2014

BioMed Research International

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Tannins, a group of major active components of Chinese rhubarb and widely distributed in nature, have a significant antidiarrhoeal activity. Aquaporins (AQPs) 2 and 3 play important roles in regulating water transfer during diarrhoea. The present study aims to determine the effect of the total tannins extract of rhubarb on aquaporins (AQPs) 2 and 3 in diarrhoea mice and HT-29 cells both induced by magnesium sulphate (MgSO4). Our results showed that rhubarb tannins extract (RTE) significantly decreased the faecal water content in colon and evaluation index of defecation of diarrhoea mice. Interestingly, RTE could markedly reduce the mRNA and protein expression levels of AQPs 2 and 3 in apical and lateral mucosal epithelial cells in the colons of diarrhoea mice and HT-29 cells both induced by MgSO4 in a dose-dependent manner. Furthermore, RTE suppressed the production of cyclic monophosphate- (cAMP-) dependent protein kinase A catalytic subunits α (PKA C-α) and phosphorylated cAMP response element-binding protein (p-CREB, Ser133) in MgSO4-induced HT-29 cells. Our data showed for the first time that RTE inhibit AQPs 2 and 3 expression in vivo and in vitro via downregulating PKA/p-CREB signal pathway, which accounts for the antidiarrhoeal effect of RTE.

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Section: Introductionmentioning

confidence: 99%

Rhubarb Tannins Extract Inhibits the Expression of Aquaporins 2 and 3 in Magnesium Sulphate-Induced Diarrhoea Model

Zheng

Wang

et al. 2014

BioMed Research International

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“…Compounds with phenolic group in its structure have a pharmacological potential [20], which is represented by activities such as antimicrobial [21–23], hypoglycemic and/or antidiabetic [24–29], and antidiarrhoeal [30–33]. …”

Section: Introductionmentioning

confidence: 99%

Levels of Tannins and Flavonoids in Medicinal Plants: Evaluating Bioprospecting Strategies

Siqueira

Cabral

Sobrinho

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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There are several species of plants used by traditional communities in the Brazilian semiarid. An approach used in the search for natural substances that possess therapeutic value is ethnobotany or ethnopharmacology. Active substances that have phenolic groups in their structure have great pharmacological potential. To establish a quantitative relationship between the species popularly considered to be antimicrobial, antidiabetic, and antidiarrheal, the contents of tannins and flavonoids were determined. The plant selection was based on an ethnobotanical survey conducted in a community located in the municipality of Altinho, northeastern Brazil. For determination of tannin content was utilized the technique of radial diffusion, and for flavonoids, an assay based on the complexation of aluminum chloride. The group of plants with antimicrobial indications showed a higher content of tannins compared to the control groups. The results evidence suggests a possible relationship between these compounds and the observed activity.

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“…Tannins, which can make the protein coagulated and denatured, have astringent properties. It is speculated that the antidiarrhoeal activity of many medicinal plants which are rich in tannins might be related to the existence of tannins (Palombo, 2006;Amabeoku, 2009). Especially, the purgative activity of rhubarb extract could be significantly increased by reducing the content of tannins (Zhong et al, 2006), and some processed products from crude rhubarb with decrease of anthraquinones and relative increase of tannins even exhibited an antidiarrhoeal activity (Zhu et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

The diarrhoeogenic and antidiarrhoeal bidirectional effects of rhubarb and its potential mechanism

Qin

Wang

Kong

et al. 2011

Journal of Ethnopharmacology

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Antidiarrhoeal activity of Geranium incanum Burm. f. (Geraniaceae) leaf aqueous extract in mice

Cited by 32 publications

References 9 publications

Rhubarb Tannins Extract Inhibits the Expression of Aquaporins 2 and 3 in Magnesium Sulphate-Induced Diarrhoea Model

Rhubarb Tannins Extract Inhibits the Expression of Aquaporins 2 and 3 in Magnesium Sulphate-Induced Diarrhoea Model

Levels of Tannins and Flavonoids in Medicinal Plants: Evaluating Bioprospecting Strategies

The diarrhoeogenic and antidiarrhoeal bidirectional effects of rhubarb and its potential mechanism

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