Anticonvulsant activity of bioflavonoid gossypin

Duraisami, Rasilingam; Duraisamy, Srinivasan; Subramanian, R. V.

doi:10.3329/bjp.v4i1.1081

Cited by 28 publications

(19 citation statements)

References 10 publications

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“…On the other hand STR induces convulsions by antagonising glycine receptor and increases postsynaptic excitability and ongoing activity in dorsal neurons [37,38]. PTZ is the most popular and widely used chemically induced seizure model and it represents an effective model for human generalized myoclonic and also absence seizure while strychnine model is considered valid for primary generalized seizures [39].…”

Section: Discussionmentioning

confidence: 99%

Anticonvulsant and Antioxidant Effects of Methanol Extract of Stems of <i>G. arborea Roxb.</i>

Acharya¹,

Acharya²,

Kumar³

et al. 2015

JNR

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Ipomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the treatment of epilepsy and neurological disorders. In the present study, pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neurotransmitters such as Gamma-Amino Butyric Acid (GABA) in epilepsy and in psychosis dopamine, noradrenaline and serotonin contents in the rodent brain were estimated. The extract pretreatment reduced maximal electro shock; Isoniazid (INH) and Pentylenetetrazole (PTZ) induced seizures and also significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. These results suggested that the observed beneficial effect in epilepsy may be by enhancing the GABAergic system. The test drug also inhibited the apomorphine induced climbing and stereotyped behavior and showed significantly reduced levels of brain dopamine, noradrenaline and serotonin which may be due to blocking of central dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. The results obtained in present study suggest that the title plant possesses antiepileptic and antipsychotic activities in rodents.

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Section: Discussionmentioning

confidence: 99%

Anticonvulsant and Antioxidant Effects of Methanol Extract of Stems of <i>G. arborea Roxb.</i>

Acharya¹,

Acharya²,

Kumar³

et al. 2015

JNR

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“…30 Generally compounds with anticonvulsant activity in the petit mal epilepsy are effective in the pentelenetetrazole-induced seizure model. 31 Data from the study showed that the tonic convulsion produced by pentelenetetrazole was significantly delayed by ethanol extract of Cleome rutidosperma.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of central nervous system depressant activity of Cleome rutidosperma

Bose¹,

Khuntia²,

Gupta

et al. 2012

Altern Med Studies

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The central nervous system (CNS) depressant activity of the ethanol extract (200 and 400 mg/kg) and its fractions (200 mg/kg each) of the aerial parts of Cleome rutidosperma was investigated in various models. The tested extract and its fractions showed significant (P<0.01) anxiolytic, anticonvulsant activity (in treating petit mal epilepsy) without any unwanted sedation effect. These findings justify the traditional use of this plant in CNS disorders.

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“…Presence of different groups in the basic chemical structure affects solubility and water solublilty of gossypin, which is mainly due to the presence of a glucose moiety in its chemical structure [10]. In the nature, gossypin is present in different plants of Malvaceae family [20]. Presence of glucose moiety in the gossypin chemical structure makes it soluble in water wheras it is also sparingly soluble in alcohol.…”

Section: Overview Of Flavonolsmentioning

confidence: 99%

“…Further gossypin also significantly reduced the tonic extensor convulsion induced by strychnine and maximum electroshock-induced convulsions [20]. Effect of gossypin, myrcitrin and naringin were tested in elevated plus maze test to know its anxiolytic activity.…”

Section: Effect Of Gossypin On Central Nervous Systemmentioning

confidence: 99%