Evaluation of central nervous system depressant activity of Cleome rutidosperma

Abstract

The central nervous system (CNS) depressant activity of the ethanol extract (200 and 400 mg/kg) and its fractions (200 mg/kg each) of the aerial parts of Cleome rutidosperma was investigated in various models. The tested extract and its fractions showed significant (P<0.01) anxiolytic, anticonvulsant activity (in treating petit mal epilepsy) without any unwanted sedation effect. These findings justify the traditional use of this plant in CNS disorders.

Evaluation of sedative and hypnotic activities of ethanolic extract of leaves of Cleome rutidosperma DC. (Capparidaceae) in mice

“…C.rutidosperma was traditionally popular among ancient people as the treatment of paralysis, epilepsy, convulsions, spasm, and earache, different kind of pain and skin disease [4]. Although C.rutidosperma is the ethnomedicinal plant, the phytochemical analysis reveals the CNS depressant activity in animal models [7]. However, no scientific literature reported about sedative and hypnotic activity of C.rutidosperma.…”